BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

269 related articles for article (PubMed ID: 17040103)

  • 1. Metabolism-dependent mutagenicity of a compound containing a piperazinyl indazole motif: Role of a novel p450-mediated metabolic reaction involving a putative oxaziridine intermediate.
    Chen H; Murray J; Kornberg B; Dethloff L; Rock D; Nikam S; Mutlib AE
    Chem Res Toxicol; 2006 Oct; 19(10):1341-50. PubMed ID: 17040103
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation.
    Kalgutkar AS; Dalvie DK; Aubrecht J; Smith EB; Coffing SL; Cheung JR; Vage C; Lame ME; Chiang P; McClure KF; Maurer TS; Coelho RV; Soliman VF; Schildknegt K
    Drug Metab Dispos; 2007 Jun; 35(6):848-58. PubMed ID: 17344339
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nitrogen-substitution effects on the mutagenicity and cytochrome P450 isoform-selectivity of chrysene analogs.
    Yamada K; Hakura A; Kato TA; Mizutani T; Saeki K
    Mutat Res; 2005 Sep; 586(1):87-95. PubMed ID: 16087391
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The spectrum of enzymes involved in activation of 2-aminoanthracene varies with the metabolic system applied.
    Veres Z; Török G; Tóth E; Vereczkey L; Jemnitz K
    Mutat Res; 2005 Sep; 586(1):18-27. PubMed ID: 16006184
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Salmonella/human S9 mutagenicity test: a collaborative study with 58 compounds.
    Hakura A; Shimada H; Nakajima M; Sui H; Kitamoto S; Suzuki S; Satoh T
    Mutagenesis; 2005 May; 20(3):217-28. PubMed ID: 15843387
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Substituent effect on the reductive N-dearylation of 3-(indol-1-yl)-1,2-benzisoxazoles by rat liver microsomes.
    Tschirret-Guth RA; Wood HB
    Drug Metab Dispos; 2003 Aug; 31(8):999-1004. PubMed ID: 12867488
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Liver extract mediated mutagenicity of acrylonitrile.
    De Meester C; Duverger-Van Bogaert M; Lambotte-Vandepaer M; Roberfroid M; Poncelet F; Mercier M
    Toxicology; 1979 May; 13(1):7-15. PubMed ID: 390766
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
    Reddy VB; Karanam BV; Gruber WL; Wallace MA; Vincent SH; Franklin RB; Baillie TA
    Chem Res Toxicol; 2005 May; 18(5):880-8. PubMed ID: 15892582
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Mutagenicity of aromatic amines and amides with chemical models for cytochrome P450 in Ames assay.
    Inami K; Okazawa M; Mochizuki M
    Toxicol In Vitro; 2009 Sep; 23(6):986-91. PubMed ID: 19563884
    [TBL] [Abstract][Full Text] [Related]  

  • 10. NTP Technical Report on the comparative toxicity studies of allyl acetate (CAS No. 591-87-7), allyl alcohol (CAS No. 107-18-6) and acrolein (CAS No. 107-02-8) administered by gavage to F344/N rats and B6C3F1 mice.
    Irwin RD
    Toxic Rep Ser; 2006 Jul; (48):1-73, A1-H10. PubMed ID: 17160105
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel metabolic pathway of arylethers by cytochrome P450: cleavage of the oxygen-aromatic ring bond accompanying ipso-substitution by the oxygen atom of the active species in cytochrome P450 models and cytochrome P450.
    Ohe T; Mashino T; Hirobe M
    Arch Biochem Biophys; 1994 May; 310(2):402-9. PubMed ID: 8179325
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evaluation of nitroreductase and acetyltransferase participation in N-nitrosodiethylamine genotoxicity.
    Aiub CA; Mazzei JL; Pinto LF; Felzenszwalb I
    Chem Biol Interact; 2006 Jun; 161(2):146-54. PubMed ID: 16720019
    [TBL] [Abstract][Full Text] [Related]  

  • 13. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
    Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
    Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel.
    Dansette PM; Thébault S; Bertho G; Mansuy D
    Chem Res Toxicol; 2010 Jul; 23(7):1268-74. PubMed ID: 20557086
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Comparison of imidazole- and 2-methyl imidazole-containing farnesyl-protein transferase inhibitors: interaction with and metabolism by rat hepatic cytochrome P450s.
    Tang C; Chiba M; Nishime J; Hochman JH; Chen I; Williams TM; Lin JH
    Drug Metab Dispos; 2000 Jun; 28(6):680-6. PubMed ID: 10820141
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Metabolic perspectives on in vitro toxicity tests.
    Oesch F; Glatt H; Utesch D
    Xenobiotica; 1988 Jan; 18 Suppl 1():35-44. PubMed ID: 3125692
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Standardization of conditions for the metabolic activation of N-nitrosodiethylamine in mutagenicity tests.
    Aiub CA; Pinto LF; Felzenszwalb I
    Genet Mol Res; 2004 Jun; 3(2):264-72. PubMed ID: 15266397
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists.
    Tang W; Stearns RA; Wang RW; Miller RR; Chen Q; Ngui J; Bakshi RK; Nargund RP; Dean DC; Baillie TA
    Xenobiotica; 2008 Nov; 38(11):1437-51. PubMed ID: 18841517
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mutagenicity of some derivatives of dipyrido[1,2-a:3',2'-d]imidazoles in Salmonella typhimurium with metabolic activation by rat liver and small intestine subcellular fractions.
    N'Goy K; Saint-Ruf G; de Meester C
    Mutat Res; 1985; 156(1-2):53-9. PubMed ID: 3889627
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes.
    Yenes S; Commandeur JN; Vermeulen NP; Messeguer A
    Chem Res Toxicol; 2004 Jul; 17(7):904-13. PubMed ID: 15257615
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.