BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

119 related articles for article (PubMed ID: 17049425)

  • 1. Quantitative analysis of benzo[a]pyrene biotransformation and adduct formation in Ahr knockout mice.
    Sagredo C; Øvrebø S; Haugen A; Fujii-Kuriyama Y; Baera R; Botnen IV; Mollerup S
    Toxicol Lett; 2006 Dec; 167(3):173-82. PubMed ID: 17049425
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Biotransformation of benzo[a]pyrene in Ahr knockout mice is dependent on time and route of exposure.
    Sagredo C; Mollerup S; Cole KJ; Phillips DH; Uppstad H; Øvrebø S
    Chem Res Toxicol; 2009 Mar; 22(3):584-91. PubMed ID: 19216581
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Induction of CYP1A1 and CYP1B1 in liver and lung by benzo(a)pyrene and 7,12-d imethylbenz(a)anthracene do not affect distribution of polycyclic hydrocarbons to target tissue: role of AhR and CYP1B1 in bone marrow cytotoxicity.
    Galván N; Teske DE; Zhou G; Moorthy B; MacWilliams PS; Czuprynski CJ; Jefcoate CR
    Toxicol Appl Pharmacol; 2005 Feb; 202(3):244-57. PubMed ID: 15667830
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo.
    Kondraganti SR; Fernandez-Salguero P; Gonzalez FJ; Ramos KS; Jiang W; Moorthy B
    Int J Cancer; 2003 Jan; 103(1):5-11. PubMed ID: 12455047
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Maternal intake of quercetin during gestation alters ex vivo benzo[a]pyrene metabolism and DNA adduct formation in adult offspring.
    Vanhees K; van Schooten FJ; Moonen EJ; Maas LM; van Waalwijk van Doorn-Khosrovani SB; Godschalk RW
    Mutagenesis; 2012 Jul; 27(4):445-51. PubMed ID: 22334599
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Induction of CYP1A1 and CYP1B1 and formation of carcinogen-DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene.
    Keshava C; Divi RL; Whipkey DL; Frye BL; McCanlies E; Kuo M; Poirier MC; Weston A
    Cancer Lett; 2005 Apr; 221(2):213-24. PubMed ID: 15808407
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Influence of TCDD and natural Ah receptor agonists on benzo[a]pyrene-DNA adduct formation in the Caco-2 human colon cell line.
    de Waard PW; de Kok TM; Maas LM; Peijnenburg AA; Hoogenboom RL; Aarts JM; van Schooten FJ
    Mutagenesis; 2008 Jan; 23(1):67-73. PubMed ID: 18065724
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Role of cytochrome P4501B1 in benzo[a]pyrene bioactivation to DNA-binding metabolites in mouse vascular smooth muscle cells: evidence from 32P-postlabeling for formation of 3-hydroxybenzo[a]pyrene and benzo[a]pyrene-3,6-quinone as major proximate genotoxic intermediates.
    Moorthy B; Miller KP; Jiang W; Williams ES; Kondraganti SR; Ramos KS
    J Pharmacol Exp Ther; 2003 Apr; 305(1):394-401. PubMed ID: 12649394
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The resveratrol analogue, 2,3',4,5'-tetramethoxystilbene, does not inhibit CYP gene expression, enzyme activity and benzo[a]pyrene-DNA adduct formation in MCF-7 cells exposed to benzo[a]pyrene.
    Einem Lindeman T; Poirier MC; Divi RL
    Mutagenesis; 2011 Sep; 26(5):629-35. PubMed ID: 21669939
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of aryl hydrocarbon receptor transactivation and DNA adduct formation by CYP1 isoform-selective metabolic deactivation of benzo[a]pyrene.
    Endo K; Uno S; Seki T; Ariga T; Kusumi Y; Mitsumata M; Yamada S; Makishima M
    Toxicol Appl Pharmacol; 2008 Jul; 230(2):135-43. PubMed ID: 18372000
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate.
    Uno S; Dalton TP; Dragin N; Curran CP; Derkenne S; Miller ML; Shertzer HG; Gonzalez FJ; Nebert DW
    Mol Pharmacol; 2006 Apr; 69(4):1103-14. PubMed ID: 16377763
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzo[a]pyrene.
    Revel A; Raanani H; Younglai E; Xu J; Rogers I; Han R; Savouret JF; Casper RF
    J Appl Toxicol; 2003; 23(4):255-61. PubMed ID: 12884409
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver.
    Galván N; Jaskula-Sztul R; MacWilliams PS; Czuprynski CJ; Jefcoate CR
    Toxicol Appl Pharmacol; 2003 Nov; 193(1):84-96. PubMed ID: 14613719
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Role of cytochrome p4501 family members in the metabolic activation of polycyclic aromatic hydrocarbons in mouse epidermis.
    Kleiner HE; Vulimiri SV; Hatten WB; Reed MJ; Nebert DW; Jefcoate CR; DiGiovanni J
    Chem Res Toxicol; 2004 Dec; 17(12):1667-74. PubMed ID: 15606143
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Induction of Cyp1a1 and Cyp1b1 and formation of DNA adducts in C57BL/6, Balb/c, and F1 mice following in utero exposure to 3-methylcholanthrene.
    Xu M; Nelson GB; Moore JE; McCoy TP; Dai J; Manderville RA; Ross JA; Miller MS
    Toxicol Appl Pharmacol; 2005 Nov; 209(1):28-38. PubMed ID: 15885734
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels.
    Uno S; Dalton TP; Shertzer HG; Genter MB; Warshawsky D; Talaska G; Nebert DW
    Biochem Biophys Res Commun; 2001 Dec; 289(5):1049-56. PubMed ID: 11741297
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Sustained overexpression of CYP1A1 and 1B1 and steady accumulation of DNA adducts by low-dose, continuous exposure to benzo[a]pyrene by polymeric implants.
    Jeyabalan J; Vadhanam MV; Ravoori S; Gupta RC
    Chem Res Toxicol; 2011 Nov; 24(11):1937-43. PubMed ID: 21942922
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The 4S benzo(a)pyrene-binding protein is not a transcriptional activator of Cyp1a1 gene in Ah receptor-deficient (AHR -/-) transgenic mice.
    Foussat J; Costet P; Galtier P; Pineau T; Lesca P
    Arch Biochem Biophys; 1998 Jan; 349(2):349-55. PubMed ID: 9448724
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-induced CYP1A1 gene expression by aryl hydrocarbon receptor pathway.
    Cherng SH; Lin P; Yang JL; Hsu SL; Lee H
    Toxicol Appl Pharmacol; 2001 Jan; 170(1):63-8. PubMed ID: 11141357
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants.
    Líbalová H; Krčková S; Uhlířová K; Milcová A; Schmuczerová J; Ciganek M; Kléma J; Machala M; Šrám RJ; Topinka J
    Toxicol Lett; 2014 Mar; 225(3):350-7. PubMed ID: 24472612
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.