BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

533 related articles for article (PubMed ID: 17051221)

  • 1. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
    Shen Y; Joachimiak A; Rosner MR; Tang WJ
    Nature; 2006 Oct; 443(7113):870-4. PubMed ID: 17051221
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme.
    Guo Q; Manolopoulou M; Bian Y; Schilling AB; Tang WJ
    J Mol Biol; 2010 Jan; 395(2):430-43. PubMed ID: 19896952
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.
    Im H; Manolopoulou M; Malito E; Shen Y; Zhao J; Neant-Fery M; Sun CY; Meredith SC; Sisodia SS; Leissring MA; Tang WJ
    J Biol Chem; 2007 Aug; 282(35):25453-63. PubMed ID: 17613531
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Toward Allosterically Increased Catalytic Activity of Insulin-Degrading Enzyme against Amyloid Peptides.
    Kurochkin IV; Guarnera E; Wong JH; Eisenhaber F; Berezovsky IN
    Biochemistry; 2017 Jan; 56(1):228-239. PubMed ID: 27982586
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Molecular Determinants of Substrate Specificity in Human Insulin-Degrading Enzyme.
    Stefanidis L; Fusco ND; Cooper SE; Smith-Carpenter JE; Alper BJ
    Biochemistry; 2018 Aug; 57(32):4903-4914. PubMed ID: 30004674
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
    Zhang Z; Liang WG; Bailey LJ; Tan YZ; Wei H; Wang A; Farcasanu M; Woods VA; McCord LA; Lee D; Shang W; Deprez-Poulain R; Deprez B; Liu DR; Koide A; Koide S; Kossiakoff AA; Li S; Carragher B; Potter CS; Tang WJ
    Elife; 2018 Mar; 7():. PubMed ID: 29596046
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme.
    Çakir B; Dağliyan O; Dağyildiz E; Bariş İ; Kavakli IH; Kizilel S; Türkay M
    PLoS One; 2012; 7(2):e31787. PubMed ID: 22355395
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition.
    Li P; Kuo WL; Yousef M; Rosner MR; Tang WJ
    Biochem Biophys Res Commun; 2006 May; 343(4):1032-7. PubMed ID: 16574064
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.
    Malito E; Ralat LA; Manolopoulou M; Tsay JL; Wadlington NL; Tang WJ
    Biochemistry; 2008 Dec; 47(48):12822-34. PubMed ID: 18986166
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.
    McCord LA; Liang WG; Dowdell E; Kalas V; Hoey RJ; Koide A; Koide S; Tang WJ
    Proc Natl Acad Sci U S A; 2013 Aug; 110(34):13827-32. PubMed ID: 23922390
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme.
    Manolopoulou M; Guo Q; Malito E; Schilling AB; Tang WJ
    J Biol Chem; 2009 May; 284(21):14177-88. PubMed ID: 19321446
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Degradation of amylin by insulin-degrading enzyme.
    Bennett RG; Duckworth WC; Hamel FG
    J Biol Chem; 2000 Nov; 275(47):36621-5. PubMed ID: 10973971
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Multiple allosteric sites are involved in the modulation of insulin-degrading-enzyme activity by somatostatin.
    Tundo GR; Di Muzio E; Ciaccio C; Sbardella D; Di Pierro D; Polticelli F; Coletta M; Marini S
    FEBS J; 2016 Oct; 283(20):3755-3770. PubMed ID: 27579517
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Degradation of Alzheimer's Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme.
    Sahoo BR; Panda PK; Liang W; Tang WJ; Ahuja R; Ramamoorthy A
    J Mol Biol; 2021 Jun; 433(13):166993. PubMed ID: 33865867
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.
    Farris W; Leissring MA; Hemming ML; Chang AY; Selkoe DJ
    Biochemistry; 2005 May; 44(17):6513-25. PubMed ID: 15850385
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity.
    Ciaccio C; Tundo GR; Grasso G; Spoto G; Marasco D; Ruvo M; Gioia M; Rizzarelli E; Coletta M
    J Mol Biol; 2009 Feb; 385(5):1556-67. PubMed ID: 19073193
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus.
    Tang WJ
    Trends Endocrinol Metab; 2016 Jan; 27(1):24-34. PubMed ID: 26651592
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
    Farris W; Mansourian S; Chang Y; Lindsley L; Eckman EA; Frosch MP; Eckman CB; Tanzi RE; Selkoe DJ; Guenette S
    Proc Natl Acad Sci U S A; 2003 Apr; 100(7):4162-7. PubMed ID: 12634421
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease.
    Fernández-Gamba A; Leal MC; Morelli L; Castaño EM
    Curr Pharm Des; 2009; 15(31):3644-55. PubMed ID: 19925417
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Amyloidogenic determinant as a substrate recognition motif of insulin-degrading enzyme.
    Kurochkin IV
    FEBS Lett; 1998 May; 427(2):153-6. PubMed ID: 9607302
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 27.