BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

587 related articles for article (PubMed ID: 17062778)

  • 1. Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar.
    Zhang D; Wang L; Chandrasena G; Ma L; Zhu M; Zhang H; Davis CD; Humphreys WG
    Drug Metab Dispos; 2007 Jan; 35(1):139-49. PubMed ID: 17062778
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor.
    Hong H; Su H; Ma L; Yao M; Iyer RA; Humphreys WG; Christopher LJ
    Drug Metab Dispos; 2011 Sep; 39(9):1658-67. PubMed ID: 21673131
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.
    Zhang D; Wang L; Raghavan N; Zhang H; Li W; Cheng PT; Yao M; Zhang L; Zhu M; Bonacorsi S; Yeola S; Mitroka J; Hariharan N; Hosagrahara V; Chandrasena G; Shyu WC; Humphreys WG
    Drug Metab Dispos; 2007 Jan; 35(1):150-67. PubMed ID: 17062777
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural elucidation of human oxidative metabolites of muraglitazar: use of microbial bioreactors in the biosynthesis of metabolite standards.
    Zhang D; Zhang H; Aranibar N; Hanson R; Huang Y; Cheng PT; Wu S; Bonacorsi S; Zhu M; Swaminathan A; Humphreys WG
    Drug Metab Dispos; 2006 Feb; 34(2):267-80. PubMed ID: 16280454
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Plasma stability-dependent circulation of acyl glucuronide metabolites in humans: how circulating metabolite profiles of muraglitazar and peliglitazar can lead to misleading risk assessment.
    Zhang D; Raghavan N; Wang L; Xue Y; Obermeier M; Chen S; Tao S; Zhang H; Cheng PT; Li W; Ramanathan R; Yang Z; Humphreys WG
    Drug Metab Dispos; 2011 Jan; 39(1):123-31. PubMed ID: 20876787
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites.
    Avent KM; DeVoss JJ; Gillam EM
    Chem Res Toxicol; 2006 Jul; 19(7):914-20. PubMed ID: 16841959
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine.
    Teiber JF; Hollenberg PF
    Carcinogenesis; 2000 Aug; 21(8):1559-66. PubMed ID: 10910959
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers.
    Koyama E; Chiba K; Tani M; Ishizaki T
    J Pharmacol Exp Ther; 1996 Jul; 278(1):21-30. PubMed ID: 8764331
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism.
    Yang TJ; Krausz KW; Sai Y; Gonzalez FJ; Gelboin HV
    Drug Metab Dispos; 1999 Jan; 27(1):102-9. PubMed ID: 9884317
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vitro metabolism of jaceosidin and characterization of cytochrome P450 and UDP-glucuronosyltransferase enzymes in human liver microsomes.
    Song WY; Ji HY; Baek NI; Jeong TS; Lee HS
    Arch Pharm Res; 2010 Dec; 33(12):1985-96. PubMed ID: 21191764
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro.
    Spracklin DK; Hankins DC; Fisher JM; Thummel KE; Kharasch ED
    J Pharmacol Exp Ther; 1997 Apr; 281(1):400-11. PubMed ID: 9103523
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS; Hatch HL; Kosea F; Nguyen HT; Choo EF; McClure KF; Taylor TJ; Henne KR; Kuperman AV; Dombroski MA; Letavic MA
    Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mangifera indica L. extract and mangiferin modulate cytochrome P450 and UDP-glucuronosyltransferase enzymes in primary cultures of human hepatocytes.
    Rodeiro I; José Gómez-Lechón M; Perez G; Hernandez I; Herrera JA; Delgado R; Castell JV; Teresa Donato M
    Phytother Res; 2013 May; 27(5):745-52. PubMed ID: 22815239
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes.
    Iribarne C; Berthou F; Baird S; Dréano Y; Picart D; Bail JP; Beaune P; Ménez JF
    Chem Res Toxicol; 1996 Mar; 9(2):365-73. PubMed ID: 8839037
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases.
    Sridar C; Goosen TC; Kent UM; Williams JA; Hollenberg PF
    Drug Metab Dispos; 2004 Jun; 32(6):587-94. PubMed ID: 15155549
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study.
    Obach RS; Cox LM; Tremaine LM
    Drug Metab Dispos; 2005 Feb; 33(2):262-70. PubMed ID: 15547048
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.
    Sharer JE; Wrighton SA
    Drug Metab Dispos; 1996 Apr; 24(4):487-94. PubMed ID: 8801065
    [TBL] [Abstract][Full Text] [Related]  

  • 18. AM-2201 Inhibits Multiple Cytochrome P450 and Uridine 5'-Diphospho-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes.
    Kim JH; Kwon SS; Kong TY; Cheong JC; Kim HS; In MK; Lee HS
    Molecules; 2017 Mar; 22(3):. PubMed ID: 28287454
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pharmacokinetics, disposition and lipid-modulating activity of 5-{2-[4-(3,4-difluorophenoxy)-phenyl]-ethylsulfamoyl}-2-methyl-benzoic acid, a potent and subtype-selective peroxisome proliferator-activated receptor alpha agonist in preclinical species and human.
    Frederick KS; Maurer TS; Kalgutkar AS; Royer LJ; Francone OL; Winter SM; Terra SG; Chen D; Gao X
    Xenobiotica; 2009 Oct; 39(10):766-81. PubMed ID: 19622022
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Metabolism of vanoxerine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes.
    Cherstniakova SA; Bi D; Fuller DR; Mojsiak JZ; Collins JM; Cantilena LR
    Drug Metab Dispos; 2001 Sep; 29(9):1216-20. PubMed ID: 11502731
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 30.