BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

75 related articles for article (PubMed ID: 17073441)

  • 1. Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1.
    Yamaguchi H; Durell SR; Feng H; Bai Y; Anderson CW; Appella E
    Biochemistry; 2006 Nov; 45(44):13193-202. PubMed ID: 17073441
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A small molecular scaffold for selective inhibition of Wip1 phosphatase.
    Bang J; Yamaguchi H; Durell SR; Appella E; Appella DH
    ChemMedChem; 2008 Feb; 3(2):230-2. PubMed ID: 18022979
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Regulation of the Wip1 phosphatase and its effects on the stress response.
    Lowe J; Cha H; Lee MO; Mazur SJ; Appella E; Fornace AJ
    Front Biosci (Landmark Ed); 2012 Jan; 17(4):1480-98. PubMed ID: 22201816
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations.
    Liu TT; Yang T; Gao MN; Chen KX; Yang S; Yu KQ; Jiang HL
    Acta Pharmacol Sin; 2019 Jun; 40(6):850-858. PubMed ID: 30796354
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction.
    Gilmartin AG; Faitg TH; Richter M; Groy A; Seefeld MA; Darcy MG; Peng X; Federowicz K; Yang J; Zhang SY; Minthorn E; Jaworski JP; Schaber M; Martens S; McNulty DE; Sinnamon RH; Zhang H; Kirkpatrick RB; Nevins N; Cui G; Pietrak B; Diaz E; Jones A; Brandt M; Schwartz B; Heerding DA; Kumar R
    Nat Chem Biol; 2014 Mar; 10(3):181-7. PubMed ID: 24390428
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Wip1 phosphatase in breast cancer.
    Emelyanov A; Bulavin DV
    Oncogene; 2015 Aug; 34(34):4429-38. PubMed ID: 25381821
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).
    Hayashi R; Tanoue K; Durell SR; Chatterjee DK; Jenkins LM; Appella DH; Appella E
    Biochemistry; 2011 May; 50(21):4537-49. PubMed ID: 21528848
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Characterization of the active site and a unique uncompetitive inhibitor of the PPM1-type protein phosphatase PPM1D.
    Chuman Y; Yagi H; Fukuda T; Nomura T; Matsukizono M; Shimohigashi Y; Sakaguchi K
    Protein Pept Lett; 2008; 15(9):938-48. PubMed ID: 18991770
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.
    Rayter S; Elliott R; Travers J; Rowlands MG; Richardson TB; Boxall K; Jones K; Linardopoulos S; Workman P; Aherne W; Lord CJ; Ashworth A
    Oncogene; 2008 Feb; 27(8):1036-44. PubMed ID: 17700519
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein-Ligand Interactions and High Selectivity.
    Collie GW; Clark MA; Keefe AD; Madin A; Read JA; Rivers EL; Zhang Y
    J Med Chem; 2024 Jan; 67(2):864-884. PubMed ID: 38197367
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen.
    Clausse V; Fang Y; Tao D; Tagad HD; Sun H; Wang Y; Karavadhi S; Lane K; Shi ZD; Vasalatiy O; LeClair CA; Eells R; Shen M; Patnaik S; Appella E; Coussens NP; Hall MD; Appella DH
    ACS Pharmacol Transl Sci; 2022 Oct; 5(10):993-1006. PubMed ID: 36268125
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Alkyl-substituted N-methylaryl-N'-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase.
    Robello M; Zheng H; Saha M; George Rosenker KM; Debnath S; Kumar JP; Tagad HD; Mazur SJ; Appella E; Appella DH
    Eur J Med Chem; 2022 Dec; 243():114763. PubMed ID: 36179402
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.
    Miller PG; Sathappa M; Moroco JA; Jiang W; Qian Y; Iqbal S; Guo Q; Giacomelli AO; Shaw S; Vernier C; Bajrami B; Yang X; Raffier C; Sperling AS; Gibson CJ; Kahn J; Jin C; Ranaghan M; Caliman A; Brousseau M; Fischer ES; Lintner R; Piccioni F; Campbell AJ; Root DE; Garvie CW; Ebert BL
    Nat Commun; 2022 Jun; 13(1):3778. PubMed ID: 35773251
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Her2 promotes early dissemination of breast cancer by suppressing the p38-MK2-Hsp27 pathway that is targetable by Wip1 inhibition.
    Wang J; Wang G; Cheng D; Huang S; Chang A; Tan X; Wang Q; Zhao S; Wu D; Liu AT; Yang S; Xiang R; Sun P
    Oncogene; 2020 Oct; 39(40):6313-6326. PubMed ID: 32848211
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
    Clausse V; Tao D; Debnath S; Fang Y; Tagad HD; Wang Y; Sun H; LeClair CA; Mazur SJ; Lane K; Shi ZD; Vasalatiy O; Eells R; Baker LK; Henderson MJ; Webb MR; Shen M; Hall MD; Appella E; Appella DH; Coussens NP
    J Biol Chem; 2019 Nov; 294(46):17654-17668. PubMed ID: 31481464
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity.
    Debnath S; Kosek D; Tagad HD; Durell SR; Appella DH; Acevedo R; Grishaev A; Dyda F; Appella E; Mazur SJ
    J Biol Chem; 2018 May; 293(21):7993-8008. PubMed ID: 29602904
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Chemical Features Important for Activity in a Class of Inhibitors Targeting the Wip1 Flap Subdomain.
    Tagad HD; Debnath S; Clausse V; Saha M; Mazur SJ; Appella E; Appella DH
    ChemMedChem; 2018 May; 13(9):894-901. PubMed ID: 29476592
    [TBL] [Abstract][Full Text] [Related]  

  • 18.
    ; ; . PubMed ID:
    [No Abstract]   [Full Text] [Related]  

  • 19.
    ; ; . PubMed ID:
    [No Abstract]   [Full Text] [Related]  

  • 20.
    ; ; . PubMed ID:
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 4.