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6. Lowering of Pkd1 expression is sufficient to cause polycystic kidney disease. Lantinga-van Leeuwen IS; Dauwerse JG; Baelde HJ; Leonhard WN; van de Wal A; Ward CJ; Verbeek S; Deruiter MC; Breuning MH; de Heer E; Peters DJ Hum Mol Genet; 2004 Dec; 13(24):3069-77. PubMed ID: 15496422 [TBL] [Abstract][Full Text] [Related]
7. Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Boulter C; Mulroy S; Webb S; Fleming S; Brindle K; Sandford R Proc Natl Acad Sci U S A; 2001 Oct; 98(21):12174-9. PubMed ID: 11593033 [TBL] [Abstract][Full Text] [Related]
8. Increased activity of activator protein-1 transcription factor components ATF2, c-Jun, and c-Fos in human and mouse autosomal dominant polycystic kidney disease. Le NH; van der Wal A; van der Bent P; Lantinga-van Leeuwen IS; Breuning MH; van Dam H; de Heer E; Peters DJ J Am Soc Nephrol; 2005 Sep; 16(9):2724-31. PubMed ID: 16049073 [TBL] [Abstract][Full Text] [Related]
9. PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice. Ahrabi AK; Terryn S; Valenti G; Caron N; Serradeil-Le Gal C; Raufaste D; Nielsen S; Horie S; Verbavatz JM; Devuyst O J Am Soc Nephrol; 2007 Jun; 18(6):1740-53. PubMed ID: 17475819 [TBL] [Abstract][Full Text] [Related]
10. Rapamycin-mediated suppression of renal cyst expansion in del34 Pkd1-/- mutant mouse embryos: an investigation of the feasibility of renal cyst prevention in the foetus. Stayner C; Shields J; Slobbe L; Shillingford JM; Weimbs T; Eccles MR Nephrology (Carlton); 2012 Nov; 17(8):739-47. PubMed ID: 22725947 [TBL] [Abstract][Full Text] [Related]
11. Progressive renal distortion by multiple cysts in transgenic mice expressing artificial microRNAs against Pkd1. Wang E; Hsieh-Li HM; Chiou YY; Chien YL; Ho HH; Chin HJ; Wang CK; Liang SC; Jiang ST J Pathol; 2010 Nov; 222(3):238-48. PubMed ID: 20814903 [TBL] [Abstract][Full Text] [Related]
12. Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease. Hassane S; Leonhard WN; van der Wal A; Hawinkels LJ; Lantinga-van Leeuwen IS; ten Dijke P; Breuning MH; de Heer E; Peters DJ J Pathol; 2010 Sep; 222(1):21-31. PubMed ID: 20549648 [TBL] [Abstract][Full Text] [Related]
13. Haploinsufficiency of Pkd2 is associated with increased tubular cell proliferation and interstitial fibrosis in two murine Pkd2 models. Chang MY; Parker E; Ibrahim S; Shortland JR; Nahas ME; Haylor JL; Ong AC Nephrol Dial Transplant; 2006 Aug; 21(8):2078-84. PubMed ID: 16720597 [TBL] [Abstract][Full Text] [Related]
14. Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Lu W; Peissel B; Babakhanlou H; Pavlova A; Geng L; Fan X; Larson C; Brent G; Zhou J Nat Genet; 1997 Oct; 17(2):179-81. PubMed ID: 9326937 [TBL] [Abstract][Full Text] [Related]
15. The PKD1 gene product, "polycystin-1," is a tyrosine-phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia. Wilson PD; Geng L; Li X; Burrow CR Lab Invest; 1999 Oct; 79(10):1311-23. PubMed ID: 10532593 [TBL] [Abstract][Full Text] [Related]
16. In vitro cystogenesis: the search for drugs antagonizing cyst development. Ibraghimov-Beskrovnaya O; Bukanov NO Nephrol Ther; 2006 Jan; 2 Suppl 2():S109-14. PubMed ID: 17373209 [TBL] [Abstract][Full Text] [Related]
18. Peptides from the PKD repeats of polycystin, the PKD1 gene product, modulate pattern formation in the developing kidney. van Adelsberg J Dev Genet; 1999; 24(3-4):299-308. PubMed ID: 10322638 [TBL] [Abstract][Full Text] [Related]
19. Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. Nauli SM; Rossetti S; Kolb RJ; Alenghat FJ; Consugar MB; Harris PC; Ingber DE; Loghman-Adham M; Zhou J J Am Soc Nephrol; 2006 Apr; 17(4):1015-25. PubMed ID: 16565258 [TBL] [Abstract][Full Text] [Related]
20. A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype. Pritchard L; Sloane-Stanley JA; Sharpe JA; Aspinwall R; Lu W; Buckle V; Strmecki L; Walker D; Ward CJ; Alpers CE; Zhou J; Wood WG; Harris PC Hum Mol Genet; 2000 Nov; 9(18):2617-27. PubMed ID: 11063721 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]