BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

356 related articles for article (PubMed ID: 17097057)

  • 1. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide.
    Thimmulappa RK; Scollick C; Traore K; Yates M; Trush MA; Liby KT; Sporn MB; Yamamoto M; Kensler TW; Biswal S
    Biochem Biophys Res Commun; 2006 Dec; 351(4):883-9. PubMed ID: 17097057
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
    Thimmulappa RK; Fuchs RJ; Malhotra D; Scollick C; Traore K; Bream JH; Trush MA; Liby KT; Sporn MB; Kensler TW; Biswal S
    Antioxid Redox Signal; 2007 Nov; 9(11):1963-70. PubMed ID: 17822364
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.
    Sussan TE; Rangasamy T; Blake DJ; Malhotra D; El-Haddad H; Bedja D; Yates MS; Kombairaju P; Yamamoto M; Liby KT; Sporn MB; Gabrielson KL; Champion HC; Tuder RM; Kensler TW; Biswal S
    Proc Natl Acad Sci U S A; 2009 Jan; 106(1):250-5. PubMed ID: 19104057
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy.
    Xu D; Chen L; Chen X; Wen Y; Yu C; Yao J; Wu H; Wang X; Xia Q; Kong X
    Cell Death Dis; 2017 Aug; 8(8):e2983. PubMed ID: 28796242
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice.
    Osburn WO; Yates MS; Dolan PD; Chen S; Liby KT; Sporn MB; Taguchi K; Yamamoto M; Kensler TW
    Toxicol Sci; 2008 Jul; 104(1):218-27. PubMed ID: 18417483
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling.
    Liby K; Hock T; Yore MM; Suh N; Place AE; Risingsong R; Williams CR; Royce DB; Honda T; Honda Y; Gribble GW; Hill-Kapturczak N; Agarwal A; Sporn MB
    Cancer Res; 2005 Jun; 65(11):4789-98. PubMed ID: 15930299
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The effect of ex vivo CDDO-Me activation on nuclear factor erythroid 2-related factor 2 pathway in white blood cells from patients with septic shock.
    Noel S; Zheng L; Navas-Acien A; Fuchs RJ
    Shock; 2014 Nov; 42(5):392-9. PubMed ID: 25105464
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole.
    Yates MS; Kwak MK; Egner PA; Groopman JD; Bodreddigari S; Sutter TR; Baumgartner KJ; Roebuck BD; Liby KT; Yore MM; Honda T; Gribble GW; Sporn MB; Kensler TW
    Cancer Res; 2006 Feb; 66(4):2488-94. PubMed ID: 16489057
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.
    Xu Z; Cho H; Hartsock MJ; Mitchell KL; Gong J; Wu L; Wei Y; Wang S; Thimmulappa RK; Sporn MB; Biswal S; Welsbie DS; Duh EJ
    J Neurochem; 2015 Apr; 133(2):233-41. PubMed ID: 25683606
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death.
    Himori N; Yamamoto K; Maruyama K; Ryu M; Taguchi K; Yamamoto M; Nakazawa T
    J Neurochem; 2013 Dec; 127(5):669-80. PubMed ID: 23721546
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CDDO-Im protects from acetaminophen hepatotoxicity through induction of Nrf2-dependent genes.
    Reisman SA; Buckley DB; Tanaka Y; Klaassen CD
    Toxicol Appl Pharmacol; 2009 Apr; 236(1):109-14. PubMed ID: 19371629
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice.
    Reddy NM; Suryanaraya V; Yates MS; Kleeberger SR; Hassoun PM; Yamamoto M; Liby KT; Sporn MB; Kensler TW; Reddy SP
    Am J Respir Crit Care Med; 2009 Nov; 180(9):867-74. PubMed ID: 19679692
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.
    Shin S; Wakabayashi J; Yates MS; Wakabayashi N; Dolan PM; Aja S; Liby KT; Sporn MB; Yamamoto M; Kensler TW
    Eur J Pharmacol; 2009 Oct; 620(1-3):138-44. PubMed ID: 19698707
    [TBL] [Abstract][Full Text] [Related]  

  • 14. NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.
    Kong X; Thimmulappa R; Kombairaju P; Biswal S
    J Immunol; 2010 Jul; 185(1):569-77. PubMed ID: 20511556
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.
    Cao M; Onyango EO; Williams CR; Royce DB; Gribble GW; Sporn MB; Liby KT
    Pharmacol Res; 2015 Oct; 100():135-47. PubMed ID: 26238177
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Triterpenoid CDDO-IM protects against lipopolysaccharide-induced inflammatory response and cytotoxicity in macrophages: The involvement of the NF-κB signaling pathway.
    Ahmed H; Amin U; Sun X; Pitts DR; Li Y; Zhu H; Jia Z
    Exp Biol Med (Maywood); 2022 Apr; 247(8):683-690. PubMed ID: 35034476
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN.
    Pitha-Rowe I; Liby K; Royce D; Sporn M
    Invest Ophthalmol Vis Sci; 2009 Nov; 50(11):5339-47. PubMed ID: 19494206
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice.
    Liu M; Reddy NM; Higbee EM; Potteti HR; Noel S; Racusen L; Kensler TW; Sporn MB; Reddy SP; Rabb H
    Kidney Int; 2014 Jan; 85(1):134-41. PubMed ID: 24088953
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cytoprotection of human endothelial cells against oxidative stress by 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im): application of systems biology to understand the mechanism of action.
    Wang X; Bynum JA; Stavchansky S; Bowman PD
    Eur J Pharmacol; 2014 Jul; 734():122-31. PubMed ID: 24703885
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
    Thimmulappa RK; Lee H; Rangasamy T; Reddy SP; Yamamoto M; Kensler TW; Biswal S
    J Clin Invest; 2006 Apr; 116(4):984-95. PubMed ID: 16585964
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.