112 related articles for article (PubMed ID: 17113558)
1. Binding thermodynamics of substituted diaminopyrimidine renin inhibitors.
Sarver RW; Peevers J; Cody WL; Ciske FL; Dyer J; Emerson SD; Hagadorn JC; Holsworth DD; Jalaie M; Kaufman M; Mastronardi M; McConnell P; Powell NA; Quin J; Van Huis CA; Zhang E; Mochalkin I
Anal Biochem; 2007 Jan; 360(1):30-40. PubMed ID: 17113558
[TBL] [Abstract][Full Text] [Related]
2. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.
Baum B; Muley L; Heine A; Smolinski M; Hangauer D; Klebe G
J Mol Biol; 2009 Aug; 391(3):552-64. PubMed ID: 19520086
[TBL] [Abstract][Full Text] [Related]
3. Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution.
Steuber H; Heine A; Klebe G
J Mol Biol; 2007 May; 368(3):618-38. PubMed ID: 17368668
[TBL] [Abstract][Full Text] [Related]
4. Molecular basis of resistance to HIV-1 protease inhibition: a plausible hypothesis.
Luque I; Todd MJ; Gómez J; Semo N; Freire E
Biochemistry; 1998 Apr; 37(17):5791-7. PubMed ID: 9558312
[TBL] [Abstract][Full Text] [Related]
5. Role of inhibitor aliphatic chain in the thermodynamics of inhibitor binding to Escherichia coli enoyl-ACP reductase and the Phe203Leu mutant: a proposed mechanism for drug resistance.
Protasevich II; Brouillette CG; Snow ME; Dunham S; Rubin JR; Gogliotti R; Siegel K
Biochemistry; 2004 Oct; 43(42):13380-9. PubMed ID: 15491144
[TBL] [Abstract][Full Text] [Related]
6. Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors.
Holsworth DD; Jalaie M; Belliotti T; Cai C; Collard W; Ferreira S; Powell NA; Stier M; Zhang E; McConnell P; Mochalkin I; Ryan MJ; Bryant J; Li T; Kasani A; Subedi R; Maiti SN; Edmunds JJ
Bioorg Med Chem Lett; 2007 Jul; 17(13):3575-80. PubMed ID: 17482464
[TBL] [Abstract][Full Text] [Related]
7. The thermodynamics of protein-ligand interaction and solvation: insights for ligand design.
Olsson TS; Williams MA; Pitt WR; Ladbury JE
J Mol Biol; 2008 Dec; 384(4):1002-17. PubMed ID: 18930735
[TBL] [Abstract][Full Text] [Related]
8. The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex--Part 2.
Kohrt JT; Filipski KJ; Cody WL; Cai C; Dudley DA; Van Huis CA; Willardsen JA; Narasimhan LS; Zhang E; Rapundalo ST; Saiya-Cork K; Leadley RJ; Edmunds JJ
Bioorg Med Chem Lett; 2006 Feb; 16(4):1060-4. PubMed ID: 16289811
[TBL] [Abstract][Full Text] [Related]
9. Understanding binding affinity: a combined isothermal titration calorimetry/molecular dynamics study of the binding of a series of hydrophobically modified benzamidinium chloride inhibitors to trypsin.
Talhout R; Villa A; Mark AE; Engberts JB
J Am Chem Soc; 2003 Sep; 125(35):10570-9. PubMed ID: 12940739
[TBL] [Abstract][Full Text] [Related]
10. Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.
Bezençon O; Bur D; Weller T; Richard-Bildstein S; Remen L; Sifferlen T; Corminboeuf O; Grisostomi C; Boss C; Prade L; Delahaye S; Treiber A; Strickner P; Binkert C; Hess P; Steiner B; Fischli W
J Med Chem; 2009 Jun; 52(12):3689-702. PubMed ID: 19358611
[TBL] [Abstract][Full Text] [Related]
11. Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis.
Geitmann M; Danielson UH
Bioorg Med Chem; 2007 Dec; 15(23):7344-54. PubMed ID: 17870544
[TBL] [Abstract][Full Text] [Related]
12. Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets.
Maibaum J; Stutz S; Göschke R; Rigollier P; Yamaguchi Y; Cumin F; Rahuel J; Baum HP; Cohen NC; Schnell CR; Fuhrer W; Gruetter MG; Schilling W; Wood JM
J Med Chem; 2007 Oct; 50(20):4832-44. PubMed ID: 17824680
[TBL] [Abstract][Full Text] [Related]
13. More than a simple lipophilic contact: a detailed thermodynamic analysis of nonbasic residues in the s1 pocket of thrombin.
Baum B; Mohamed M; Zayed M; Gerlach C; Heine A; Hangauer D; Klebe G
J Mol Biol; 2009 Jul; 390(1):56-69. PubMed ID: 19409395
[TBL] [Abstract][Full Text] [Related]
14. Glycosidase inhibition: an assessment of the binding of 18 putative transition-state mimics.
Gloster TM; Meloncelli P; Stick RV; Zechel D; Vasella A; Davies GJ
J Am Chem Soc; 2007 Feb; 129(8):2345-54. PubMed ID: 17279749
[TBL] [Abstract][Full Text] [Related]
15. Effect of the phosphate substrate on drug-inhibitor binding to human purine nucleoside phosphorylase.
Todorova NA; Schwarz FP
Arch Biochem Biophys; 2008 Dec; 480(2):122-31. PubMed ID: 18938130
[TBL] [Abstract][Full Text] [Related]
16. Compensating enthalpic and entropic changes hinder binding affinity optimization.
Lafont V; Armstrong AA; Ohtaka H; Kiso Y; Mario Amzel L; Freire E
Chem Biol Drug Des; 2007 Jun; 69(6):413-22. PubMed ID: 17581235
[TBL] [Abstract][Full Text] [Related]
17. Thermodynamics of melittin binding to lipid bilayers. Aggregation and pore formation.
Klocek G; Schulthess T; Shai Y; Seelig J
Biochemistry; 2009 Mar; 48(12):2586-96. PubMed ID: 19173655
[TBL] [Abstract][Full Text] [Related]
18. Probing the effect of the amidinium group and the phenyl ring on the thermodynamics of binding of benzamidinium chloride to trypsin.
Talhout R; Engberts JB
Org Biomol Chem; 2004 Nov; 2(21):3071-4. PubMed ID: 15505709
[TBL] [Abstract][Full Text] [Related]
19. Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin.
Göschke R; Stutz S; Rasetti V; Cohen NC; Rahuel J; Rigollier P; Baum HP; Forgiarini P; Schnell CR; Wagner T; Gruetter MG; Fuhrer W; Schilling W; Cumin F; Wood JM; Maibaum J
J Med Chem; 2007 Oct; 50(20):4818-31. PubMed ID: 17824679
[TBL] [Abstract][Full Text] [Related]
20. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors.
Anderka O; Loenze P; Klabunde T; Dreyer MK; Defossa E; Wendt KU; Schmoll D
Biochemistry; 2008 Apr; 47(16):4683-91. PubMed ID: 18373353
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
