414 related articles for article (PubMed ID: 17117686)
1. Progress toward the discovery and development of efficacious BACE inhibitors.
Durham TB; Shepherd TA
Curr Opin Drug Discov Devel; 2006 Nov; 9(6):776-91. PubMed ID: 17117686
[TBL] [Abstract][Full Text] [Related]
2. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB
J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
[TBL] [Abstract][Full Text] [Related]
3. Design and development of BACE-1 inhibitors.
Cumming JN; Iserloh U; Kennedy ME
Curr Opin Drug Discov Devel; 2004 Jul; 7(4):536-56. PubMed ID: 15338962
[TBL] [Abstract][Full Text] [Related]
4. A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation.
Tanahashi H; Tabira T
Neurosci Lett; 2007 Nov; 428(2-3):103-8. PubMed ID: 17961921
[TBL] [Abstract][Full Text] [Related]
5. Progress toward a practical BACE-1 inhibitor.
Hills ID; Vacca JP
Curr Opin Drug Discov Devel; 2007 Jul; 10(4):383-91. PubMed ID: 17659479
[TBL] [Abstract][Full Text] [Related]
6. Evidence for dimeric BACE-mediated APP processing.
Jin S; Agerman K; Kolmodin K; Gustafsson E; Dahlqvist C; Jureus A; Liu G; Fälting J; Berg S; Lundkvist J; Lendahl U
Biochem Biophys Res Commun; 2010 Feb; 393(1):21-7. PubMed ID: 20097169
[TBL] [Abstract][Full Text] [Related]
7. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.
Meredith JE; Thompson LA; Toyn JH; Marcin L; Barten DM; Marcinkeviciene J; Kopcho L; Kim Y; Lin A; Guss V; Burton C; Iben L; Polson C; Cantone J; Ford M; Drexler D; Fiedler T; Lentz KA; Grace JE; Kolb J; Corsa J; Pierdomenico M; Jones K; Olson RE; Macor JE; Albright CF
J Pharmacol Exp Ther; 2008 Aug; 326(2):502-13. PubMed ID: 18499745
[TBL] [Abstract][Full Text] [Related]
8. BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
Clarke B; Demont E; Dingwall C; Dunsdon R; Faller A; Hawkins J; Hussain I; MacPherson D; Maile G; Matico R; Milner P; Mosley J; Naylor A; O'Brien A; Redshaw S; Riddell D; Rowland P; Soleil V; Smith KJ; Stanway S; Stemp G; Sweitzer S; Theobald P; Vesey D; Walter DS; Ward J; Wayne G
Bioorg Med Chem Lett; 2008 Feb; 18(3):1017-21. PubMed ID: 18166458
[TBL] [Abstract][Full Text] [Related]
9. Protein-protein interactions in the assembly and subcellular trafficking of the BACE (beta-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease.
Parsons RB; Austen BM
Biochem Soc Trans; 2007 Nov; 35(Pt 5):974-9. PubMed ID: 17956258
[TBL] [Abstract][Full Text] [Related]
10. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
Sankaranarayanan S; Price EA; Wu G; Crouthamel MC; Shi XP; Tugusheva K; Tyler KX; Kahana J; Ellis J; Jin L; Steele T; Stachel S; Coburn C; Simon AJ
J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
[TBL] [Abstract][Full Text] [Related]
11. BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
Clarke B; Demont E; Dingwall C; Dunsdon R; Faller A; Hawkins J; Hussain I; MacPherson D; Maile G; Matico R; Milner P; Mosley J; Naylor A; O'Brien A; Redshaw S; Riddell D; Rowland P; Soleil V; Smith KJ; Stanway S; Stemp G; Sweitzer S; Theobald P; Vesey D; Walter DS; Ward J; Wayne G
Bioorg Med Chem Lett; 2008 Feb; 18(3):1011-6. PubMed ID: 18171614
[TBL] [Abstract][Full Text] [Related]
12. Development and characterization of beta-secretase monolithic micro-immobilized enzyme reactor for on-line high-performance liquid chromatography studies.
Mancini F; Naldi M; Cavrini V; Andrisano V
J Chromatogr A; 2007 Dec; 1175(2):217-26. PubMed ID: 17991476
[TBL] [Abstract][Full Text] [Related]
13. BACE: Therapeutic target and potential biomarker for Alzheimer's disease.
Evin G; Barakat A; Masters CL
Int J Biochem Cell Biol; 2010 Dec; 42(12):1923-6. PubMed ID: 20817005
[TBL] [Abstract][Full Text] [Related]
14. Alzheimer's disease. A firm base for drug development.
De Strooper B; König G
Nature; 1999 Dec; 402(6761):471-2. PubMed ID: 10591201
[No Abstract] [Full Text] [Related]
15. Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Probst GD; Bowers S; Sealy JM; Stupi B; Dressen D; Jagodzinska BM; Aquino J; Gailunas A; Truong AP; Tso L; Xu YZ; Hom RK; John V; Tung JS; Pleiss MA; Tucker JA; Konradi AW; Sham HL; Jagodzinski J; Toth G; Brecht E; Yao N; Pan H; Lin M; Artis DR; Ruslim L; Bova MP; Sinha S; Yednock TA; Gauby S; Zmolek W; Quinn KP; Sauer JM
Bioorg Med Chem Lett; 2010 Oct; 20(20):6034-9. PubMed ID: 20822903
[TBL] [Abstract][Full Text] [Related]
16. Caspase-3 cleavage of GGA3 stabilizes BACE: implications for Alzheimer's disease.
Vassar R
Neuron; 2007 Jun; 54(5):671-3. PubMed ID: 17553417
[TBL] [Abstract][Full Text] [Related]
17. Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity.
Fu H; Li W; Luo J; Lee NT; Li M; Tsim KW; Pang Y; Youdim MB; Han Y
Biochem Biophys Res Commun; 2008 Feb; 366(3):631-6. PubMed ID: 18039469
[TBL] [Abstract][Full Text] [Related]
18. An inhibitor binding pocket distinct from the catalytic active site on human beta-APP cleaving enzyme.
Kornacker MG; Lai Z; Witmer M; Ma J; Hendrick J; Lee VG; Riexinger DJ; Mapelli C; Metzler W; Copeland RA
Biochemistry; 2005 Aug; 44(34):11567-73. PubMed ID: 16114893
[TBL] [Abstract][Full Text] [Related]
19. Amyloid-beta, BACE, and oxidative stress in Alzheimer's disease, a commentary on "The different aggregation state of beta-amyloid 1-42 mediates different effects on oxidative stress, neurodegeneration and BACE-1 expression".
Lee HG; Perry G; Zhu X; Nunomura A; Smith MA
Free Radic Biol Med; 2006 Jul; 41(2):188-9. PubMed ID: 16814097
[No Abstract] [Full Text] [Related]
20. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
Na CH; Jeon SH; Zhang G; Olson GL; Chae CB
J Neurochem; 2007 Jun; 101(6):1583-95. PubMed ID: 17542811
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]