BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

199 related articles for article (PubMed ID: 17126015)

  • 1. 5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile.
    Sakya SM; Hou X; Minich ML; Rast B; Shavnya A; DeMello KM; Cheng H; Li J; Jaynes BH; Mann DW; Petras CF; Seibel SB; Haven ML
    Bioorg Med Chem Lett; 2007 Feb; 17(4):1067-72. PubMed ID: 17126015
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors.
    Cheng H; Lundy DeMello KM; Li J; Sakya SM; Ando K; Kawamura K; Kato T; Rafka RJ; Jaynes BH; Ziegler CB; Stevens R; Lund LA; Mann DW; Kilroy C; Haven ML; Nimz EL; Dutra JK; Li C; Minich ML; Kolosko NL; Petras C; Silvia AM; Seibel SB
    Bioorg Med Chem Lett; 2006 Apr; 16(8):2076-80. PubMed ID: 16464588
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Comparative structure-activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition.
    Sakya SM; Shavnya A; Cheng H; Li C; Rast B; Li J; Koss DA; Jaynes BH; Mann DW; Petras CF; Seibel SB; Haven ML; Lynch MP
    Bioorg Med Chem Lett; 2008 Feb; 18(3):1042-5. PubMed ID: 18182290
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers.
    Sakya SM; Cheng H; Lundy Demello KM; Shavnya A; Minich ML; Rast B; Dutra J; Li C; Rafka RJ; Koss DA; Li J; Jaynes BH; Ziegler CB; Mann DW; Petras CF; Seibel SB; Silvia AM; George DM; Hickman A; Haven ML; Lynch MP
    Bioorg Med Chem Lett; 2006 Mar; 16(5):1202-6. PubMed ID: 16380252
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors.
    Navidpour L; Amini M; Shafaroodi H; Abdi K; Ghahremani MH; Dehpour AR; Shafiee A
    Bioorg Med Chem Lett; 2006 Sep; 16(17):4483-7. PubMed ID: 16806914
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 5-heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure-activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog.
    Sakya SM; DeMello KM; Minich ML; Rast B; Shavnya A; Rafka RJ; Koss DA; Cheng H; Li J; Jaynes BH; Ziegler CB; Mann DW; Petras CF; Seibel SB; Silvia AM; George DM; Lund LA; St Denis S; Hickman A; Haven ML; Lynch MP
    Bioorg Med Chem Lett; 2006 Jan; 16(2):288-92. PubMed ID: 16275075
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity.
    Zarghi A; Praveen Rao PN; Knaus EE
    Bioorg Med Chem; 2007 Jan; 15(2):1056-61. PubMed ID: 17067801
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors.
    Fioravanti R; Bolasco A; Manna F; Rossi F; Orallo F; Ortuso F; Alcaro S; Cirilli R
    Eur J Med Chem; 2010 Dec; 45(12):6135-8. PubMed ID: 20974503
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
    Reddy MV; Billa VK; Pallela VR; Mallireddigari MR; Boominathan R; Gabriel JL; Reddy EP
    Bioorg Med Chem; 2008 Apr; 16(7):3907-16. PubMed ID: 18272371
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.
    El-Sayed MA; Abdel-Aziz NI; Abdel-Aziz AA; El-Azab AS; ElTahir KE
    Bioorg Med Chem; 2012 May; 20(10):3306-16. PubMed ID: 22516672
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.
    El-Sayed MA; Abdel-Aziz NI; Abdel-Aziz AA; El-Azab AS; Asiri YA; Eltahir KE
    Bioorg Med Chem; 2011 Jun; 19(11):3416-24. PubMed ID: 21570309
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pyrazolo[3,4-d]pyrimidine derivatives as COX-2 selective inhibitors: synthesis and molecular modelling studies.
    Raffa D; Maggio B; Plescia F; Cascioferro S; Raimondi MV; Plescia S; Cusimano MG
    Arch Pharm (Weinheim); 2009 Jun; 342(6):321-6. PubMed ID: 19479756
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors.
    Al-Hourani BJ; Sharma SK; Suresh M; Wuest F
    Bioorg Med Chem Lett; 2012 Mar; 22(6):2235-8. PubMed ID: 22341941
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors.
    Zarghi A; Kakhgi S; Hadipoor A; Daraee B; Dadrass OG; Hedayati M
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1336-9. PubMed ID: 18226898
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.
    Harrak Y; Casula G; Basset J; Rosell G; Plescia S; Raffa D; Cusimano MG; Pouplana R; Pujol MD
    J Med Chem; 2010 Sep; 53(18):6560-71. PubMed ID: 20804197
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors.
    Ghodsi R; Zarghi A; Daraei B; Hedayati M
    Bioorg Med Chem; 2010 Feb; 18(3):1029-33. PubMed ID: 20061161
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors.
    Ranatunge RR; Earl RA; Garvey DS; Janero DR; Letts LG; Martino AM; Murty MG; Richardson SK; Schwalb DJ; Young DV; Zemtseva IS
    Bioorg Med Chem Lett; 2004 Dec; 14(24):6049-52. PubMed ID: 15546727
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Racemic and chiral sulfoxides as potential prodrugs of 4-pyrone COX-2 inhibitors.
    Caturla F; Amat M; Reinoso RF; Calaf E; Warrellow G
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3605-8. PubMed ID: 16647258
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone as a potent and orally active cyclooxygenase-2 selective inhibitor: synthesis and biological evaluation.
    Khanapure SP; Augustyniak ME; Earl RA; Garvey DS; Letts LG; Martino AM; Murty MG; Schwalb DJ; Shumway MJ; Trocha AM; Young DV; Zemtseva IS; Janero DR
    J Med Chem; 2005 Jun; 48(11):3930-4. PubMed ID: 15916445
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design and synthesis of new rofecoxib analogs as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the methanesulfonyl pharmacophore by a N-acetylsulfonamido bioisostere.
    Zarghi A; Rao PN; Knaus EE
    J Pharm Pharm Sci; 2007; 10(2):159-67. PubMed ID: 17706175
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.