These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

166 related articles for article (PubMed ID: 17154503)

  • 1. Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
    Muchmore SW; Smith RA; Stewart AO; Cowart MD; Gomtsyan A; Matulenko MA; Yu H; Severin JM; Bhagwat SS; Lee CH; Kowaluk EA; Jarvis MF; Jakob CL
    J Med Chem; 2006 Nov; 49(23):6726-31. PubMed ID: 17154503
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Deciphering ligand dependent degree of binding site closure and its implication in inhibitor design: A modeling study on human adenosine kinase.
    Bhutoria S; Ghoshal N
    J Mol Graph Model; 2010 Feb; 28(6):577-91. PubMed ID: 20089430
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
    Schumacher MA; Scott DM; Mathews II; Ealick SE; Roos DS; Ullman B; Brennan RG
    J Mol Biol; 2000 May; 298(5):875-93. PubMed ID: 10801355
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding.
    Schumacher MA; Scott DM; Mathews II; Ealick SE; Roos DS; Ullman B; Brennan RG
    J Mol Biol; 2000 Feb; 296(2):549-67. PubMed ID: 10669608
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution.
    Zhang Y; El Kouni MH; Ealick SE
    Acta Crystallogr D Biol Crystallogr; 2006 Feb; 62(Pt 2):140-5. PubMed ID: 16421444
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
    Matulenko MA; Paight ES; Frey RR; Gomtsyan A; DiDomenico S; Jiang M; Lee CH; Stewart AO; Yu H; Kohlhaas KL; Alexander KM; McGaraughty S; Mikusa J; Marsh KC; Muchmore SW; Jakob CL; Kowaluk EA; Jarvis MF; Bhagwat SS
    Bioorg Med Chem; 2007 Feb; 15(4):1586-605. PubMed ID: 17197188
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure of human adenosine kinase at 1.5 A resolution.
    Mathews II; Erion MD; Ealick SE
    Biochemistry; 1998 Nov; 37(45):15607-20. PubMed ID: 9843365
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase.
    Zhang Y; El Kouni MH; Ealick SE
    Acta Crystallogr D Biol Crystallogr; 2007 Feb; 63(Pt 2):126-34. PubMed ID: 17242506
    [TBL] [Abstract][Full Text] [Related]  

  • 9. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse.
    Jarvis MF; Yu H; Kohlhaas K; Alexander K; Lee CH; Jiang M; Bhagwat SS; Williams M; Kowaluk EA
    J Pharmacol Exp Ther; 2000 Dec; 295(3):1156-64. PubMed ID: 11082453
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy.
    Wiesner JB; Ugarkar BG; Castellino AJ; Barankiewicz J; Dumas DP; Gruber HE; Foster AC; Erion MD
    J Pharmacol Exp Ther; 1999 Jun; 289(3):1669-77. PubMed ID: 10336567
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Domain motions and the open-to-closed conformational transition of an enzyme: a normal mode analysis of S-adenosyl-L-homocysteine hydrolase.
    Wang M; Borchardt RT; Schowen RL; Kuczera K
    Biochemistry; 2005 May; 44(19):7228-39. PubMed ID: 15882061
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Conformational change of adenosine deaminase during ligand-exchange in a crystal.
    Kinoshita T; Tada T; Nakanishi I
    Biochem Biophys Res Commun; 2008 Aug; 373(1):53-7. PubMed ID: 18549808
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structures of active SRC kinase domain complexes.
    Breitenlechner CB; Kairies NA; Honold K; Scheiblich S; Koll H; Greiter E; Koch S; Schäfer W; Huber R; Engh RA
    J Mol Biol; 2005 Oct; 353(2):222-31. PubMed ID: 16168436
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Nonnucleoside inhibitors of adenosine kinase.
    Gomtsyan A; Lee CH
    Curr Pharm Des; 2004; 10(10):1093-103. PubMed ID: 15078144
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors.
    Fischmann TO; Smith CK; Mayhood TW; Myers JE; Reichert P; Mannarino A; Carr D; Zhu H; Wong J; Yang RS; Le HV; Madison VS
    Biochemistry; 2009 Mar; 48(12):2661-74. PubMed ID: 19161339
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structures of dimeric nonstandard nucleotide triphosphate pyrophosphatase from Pyrococcus horikoshii OT3: functional significance of interprotomer conformational changes.
    Lokanath NK; Pampa KJ; Takio K; Kunishima N
    J Mol Biol; 2008 Jan; 375(4):1013-25. PubMed ID: 18062990
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The three-dimensional structures of tick carboxypeptidase inhibitor in complex with A/B carboxypeptidases reveal a novel double-headed binding mode.
    Arolas JL; Popowicz GM; Lorenzo J; Sommerhoff CP; Huber R; Aviles FX; Holak TA
    J Mol Biol; 2005 Jul; 350(3):489-98. PubMed ID: 15961103
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei.
    Bernstein BE; Williams DM; Bressi JC; Kuhn P; Gelb MH; Blackburn GM; Hol WG
    J Mol Biol; 1998 Jun; 279(5):1137-48. PubMed ID: 9642090
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.
    Wang Z; Liu J; Sudom A; Ayres M; Li S; Wesche H; Powers JP; Walker NP
    Structure; 2006 Dec; 14(12):1835-44. PubMed ID: 17161373
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mechanism-based design of a protein kinase inhibitor.
    Parang K; Till JH; Ablooglu AJ; Kohanski RA; Hubbard SR; Cole PA
    Nat Struct Biol; 2001 Jan; 8(1):37-41. PubMed ID: 11135668
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.