These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

101 related articles for article (PubMed ID: 17154508)

  • 1. Three-dimensional quantitative structure-activity relationships of ATP-sensitive potassium (KATP) channel openers belonging to the 3-alkylamino-4H-1,2,4-benzo- and 3-alkylamino-4H-1,2,4-pyridothiadiazine 1,1-dioxide families.
    de Tullio P; Dupont L; Francotte P; Counerotte S; Lebrun P; Pirotte B
    J Med Chem; 2006 Nov; 49(23):6779-88. PubMed ID: 17154508
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis, and pharmacological evaluation.
    Pirotte B; Ouedraogo R; de Tullio P; Khelili S; Somers F; Boverie S; Dupont L; Fontaine J; Damas J; Lebrun P
    J Med Chem; 2000 Apr; 43(8):1456-66. PubMed ID: 10780901
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hydroxylated analogues of ATP-sensitive potassium channel openers belonging to the group of 6- and/or 7-substituted 3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: toward an improvement in sulfonylurea receptor 1 selectivity and metabolism stability.
    de Tullio P; Servais AC; Fillet M; Gillotin F; Somers F; Chiap P; Lebrun P; Pirotte B
    J Med Chem; 2011 Dec; 54(24):8353-61. PubMed ID: 22077416
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.
    de Tullio P; Boverie S; Becker B; Antoine MH; Nguyen QA; Francotte P; Counerotte S; Sebille S; Pirotte B; Lebrun P
    J Med Chem; 2005 Jul; 48(15):4990-5000. PubMed ID: 16033278
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.
    de Tullio P; Becker B; Boverie S; Dabrowski M; Wahl P; Antoine MH; Somers F; Sebille S; Ouedraogo R; Hansen JB; Lebrun P; Pirotte B
    J Med Chem; 2003 Jul; 46(15):3342-53. PubMed ID: 12852765
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 3-and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation, and structure-activity relationships.
    de Tullio P; Pirotte B; Lebrun P; Fontaine J; Dupont L; Antoine MH; Ouedraogo R; Khelili S; Maggetto C; Masereel B; Diouf O; Podona T; Delarge J
    J Med Chem; 1996 Feb; 39(4):937-48. PubMed ID: 8632417
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.
    Boverie S; Antoine MH; Somers F; Becker B; Sebille S; Ouedraogo R; Counerotte S; Pirotte B; Lebrun P; de Tullio P
    J Med Chem; 2005 May; 48(10):3492-503. PubMed ID: 15887958
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Preparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2-butylamino)-4H- and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers.
    Khelili S; de Tullio P; Lebrun P; Fillet M; Antoine MH; Ouedraogo R; Dupont L; Fontaine J; Felekidis A; Leclerc G; Delarge J; Pirotte B
    Bioorg Med Chem; 1999 Aug; 7(8):1513-20. PubMed ID: 10482443
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.
    Pirotte B; de Tullio P; Nguyen QA; Somers F; Fraikin P; Florence X; Wahl P; Hansen JB; Lebrun P
    J Med Chem; 2010 Jan; 53(1):147-54. PubMed ID: 19919106
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships.
    Pirotte B; Podona T; Diouf O; de Tullio P; Lebrun P; Dupont L; Somers F; Delarge J; Morain P; Lestage P; Lepagnol J; Spedding M
    J Med Chem; 1998 Jul; 41(16):2946-59. PubMed ID: 9685234
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 2-alkyl-3-Alkylamino-2H-Benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers?
    Ouedraogo R; Becker B; Boverie S; Somers F; Antoine MH; Pirotte B; Lebrun P; de Tullio P
    Biol Chem; 2002 Nov; 383(11):1759-68. PubMed ID: 12530541
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?
    Pirotte B; de Tullio P; Lebrun P; Antoine MH; Fontaine J; Masereel B; Schynts M; Dupont L; Herchuelz A; Delarge J
    J Med Chem; 1993 Oct; 36(21):3211-3. PubMed ID: 8230110
    [No Abstract]   [Full Text] [Related]  

  • 13. New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.
    Nielsen FE; Ebdrup S; Jensen AF; Ynddal L; Bodvarsdottir TB; Stidsen C; Worsaae A; Boonen HC; Arkhammar PO; Fremming T; Wahl P; Kornø HT; Hansen JB
    J Med Chem; 2006 Jul; 49(14):4127-39. PubMed ID: 16821773
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.
    Pirotte B; de Tullio P; Boverie S; Michaux C; Lebrun P
    J Med Chem; 2011 May; 54(9):3188-99. PubMed ID: 21428460
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and K(ATP) channel activity.
    Somers F; Ouedraogo R; Antoine MH; de Tullio P; Becker B; Fontaine J; Damas J; Dupont L; Rigo B; Delarge J; Lebrun P; Pirotte B
    J Med Chem; 2001 Aug; 44(16):2575-85. PubMed ID: 11472211
    [TBL] [Abstract][Full Text] [Related]  

  • 16. 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.
    Nielsen FE; Bodvarsdottir TB; Worsaae A; MacKay P; Stidsen CE; Boonen HC; Pridal L; Arkhammar PO; Wahl P; Ynddal L; Junager F; Dragsted N; Tagmose TM; Mogensen JP; Koch A; Treppendahl SP; Hansen JB
    J Med Chem; 2002 Sep; 45(19):4171-87. PubMed ID: 12213059
    [TBL] [Abstract][Full Text] [Related]  

  • 17. (-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization.
    Gopalakrishnan M; Buckner SA; Whiteaker KL; Shieh CC; Molinari EJ; Milicic I; Daza AV; Davis-Taber R; Scott VE; Sellers D; Chess-Williams R; Chapple CR; Liu Y; Liu D; Brioni JD; Sullivan JP; Williams M; Carroll WA; Coghlan MJ
    J Pharmacol Exp Ther; 2002 Oct; 303(1):379-86. PubMed ID: 12235274
    [TBL] [Abstract][Full Text] [Related]  

  • 18. 1,4,2-Benzo/pyridodithiazine 1,1-dioxides structurally related to the ATP-sensitive potassium channel openers 1,2,4-Benzo/pyridothiadiazine 1,1-dioxides exert a myorelaxant activity linked to a distinct mechanism of action.
    Pirotte B; de Tullio P; Florence X; Goffin E; Somers F; Boverie S; Lebrun P
    J Med Chem; 2013 Apr; 56(8):3247-56. PubMed ID: 23517501
    [TBL] [Abstract][Full Text] [Related]  

  • 19. KATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1-dioxides.
    Lebrun P; Becker B; Morel N; Ghisdal P; Antoine MH; de Tullio P; Pirotte B
    Biochem Pharmacol; 2008 Jan; 75(2):468-75. PubMed ID: 17920043
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effect on insulin release of compounds structurally related to the potassium-channel opener 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide (BPDZ 73): introduction of heteroatoms on the 3-alkylamino side chain of the benzothiadiazine 1,1-dioxide ring.
    Boverie S; Antoine MH; de Tullio P; Somers F; Becker B; Sebille S; Lebrun P; Pirotte B
    J Pharm Pharmacol; 2001 Jul; 53(7):973-80. PubMed ID: 11480549
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.