BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1680 related articles for article (PubMed ID: 17156133)

  • 21. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
    Na CH; Jeon SH; Zhang G; Olson GL; Chae CB
    J Neurochem; 2007 Jun; 101(6):1583-95. PubMed ID: 17542811
    [TBL] [Abstract][Full Text] [Related]  

  • 22. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
    Imbimbo BP; Del Giudice E; Colavito D; D'Arrigo A; Dalle Carbonare M; Villetti G; Facchinetti F; Volta R; Pietrini V; Baroc MF; Serneels L; De Strooper B; Leon A
    J Pharmacol Exp Ther; 2007 Dec; 323(3):822-30. PubMed ID: 17895400
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R; Bienkowski MJ; Shuck ME; Miao H; Tory MC; Pauley AM; Brashier JR; Stratman NC; Mathews WR; Buhl AE; Carter DB; Tomasselli AG; Parodi LA; Heinrikson RL; Gurney ME
    Nature; 1999 Dec; 402(6761):533-7. PubMed ID: 10591213
    [TBL] [Abstract][Full Text] [Related]  

  • 24. BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
    Farzan M; Schnitzler CE; Vasilieva N; Leung D; Choe H
    Proc Natl Acad Sci U S A; 2000 Aug; 97(17):9712-7. PubMed ID: 10931940
    [TBL] [Abstract][Full Text] [Related]  

  • 25. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
    Nishitomi K; Sakaguchi G; Horikoshi Y; Gray AJ; Maeda M; Hirata-Fukae C; Becker AG; Hosono M; Sakaguchi I; Minami SS; Nakajima Y; Li HF; Takeyama C; Kihara T; Ota A; Wong PC; Aisen PS; Kato A; Kinoshita N; Matsuoka Y
    J Neurochem; 2006 Dec; 99(6):1555-63. PubMed ID: 17083447
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
    Sevalle J; Ayral E; Hernandez JF; Martinez J; Checler F
    J Neurochem; 2009 Jul; 110(1):275-83. PubMed ID: 19457123
    [TBL] [Abstract][Full Text] [Related]  

  • 27. BACE inhibitor reduces APP-beta-C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration.
    Yoon SY; Choi JE; Yoon JH; Huh JW; Kim DH
    Neurobiol Dis; 2006 May; 22(2):435-44. PubMed ID: 16480887
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.
    Philipson O; Lannfelt L; Nilsson LN
    FEBS Lett; 2009 Sep; 583(18):3021-6. PubMed ID: 19683527
    [TBL] [Abstract][Full Text] [Related]  

  • 29. The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.
    Lahiri DK; Chen D; Maloney B; Holloway HW; Yu QS; Utsuki T; Giordano T; Sambamurti K; Greig NH
    J Pharmacol Exp Ther; 2007 Jan; 320(1):386-96. PubMed ID: 17003227
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application.
    Lerchner A; Machauer R; Betschart C; Veenstra S; Rueeger H; McCarthy C; Tintelnot-Blomley M; Jaton AL; Rabe S; Desrayaud S; Enz A; Staufenbiel M; Paganetti P; Rondeau JM; Neumann U
    Bioorg Med Chem Lett; 2010 Jan; 20(2):603-7. PubMed ID: 19963375
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
    Esposito L; Gan L; Yu GQ; Essrich C; Mucke L
    J Neurochem; 2004 Dec; 91(6):1260-74. PubMed ID: 15584903
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
    Sinha S; Anderson JP; Barbour R; Basi GS; Caccavello R; Davis D; Doan M; Dovey HF; Frigon N; Hong J; Jacobson-Croak K; Jewett N; Keim P; Knops J; Lieberburg I; Power M; Tan H; Tatsuno G; Tung J; Schenk D; Seubert P; Suomensaari SM; Wang S; Walker D; Zhao J; McConlogue L; John V
    Nature; 1999 Dec; 402(6761):537-40. PubMed ID: 10591214
    [TBL] [Abstract][Full Text] [Related]  

  • 33. BACE (beta-secretase) modulates the processing of APLP2 in vivo.
    Pastorino L; Ikin AF; Lamprianou S; Vacaresse N; Revelli JP; Platt K; Paganetti P; Mathews PM; Harroch S; Buxbaum JD
    Mol Cell Neurosci; 2004 Apr; 25(4):642-9. PubMed ID: 15080893
    [TBL] [Abstract][Full Text] [Related]  

  • 34. beta-Secretase, APP and Abeta in Alzheimer's disease.
    Vassar R
    Subcell Biochem; 2005; 38():79-103. PubMed ID: 15709474
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Promising anti-Alzheimer's dimer bis(7)-tacrine reduces beta-amyloid generation by directly inhibiting BACE-1 activity.
    Fu H; Li W; Luo J; Lee NT; Li M; Tsim KW; Pang Y; Youdim MB; Han Y
    Biochem Biophys Res Commun; 2008 Feb; 366(3):631-6. PubMed ID: 18039469
    [TBL] [Abstract][Full Text] [Related]  

  • 36. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S; Zhou H; Walian PJ; Jap BK
    Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Caspase-3 cleavage of GGA3 stabilizes BACE: implications for Alzheimer's disease.
    Vassar R
    Neuron; 2007 Jun; 54(5):671-3. PubMed ID: 17553417
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Anatabine lowers Alzheimer's Aβ production in vitro and in vivo.
    Paris D; Beaulieu-Abdelahad D; Bachmeier C; Reed J; Ait-Ghezala G; Bishop A; Chao J; Mathura V; Crawford F; Mullan M
    Eur J Pharmacol; 2011 Nov; 670(2-3):384-91. PubMed ID: 21958873
    [TBL] [Abstract][Full Text] [Related]  

  • 39. In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors.
    Chang WP; Koelsch G; Wong S; Downs D; Da H; Weerasena V; Gordon B; Devasamudram T; Bilcer G; Ghosh AK; Tang J
    J Neurochem; 2004 Jun; 89(6):1409-16. PubMed ID: 15189343
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Caffeine protects Alzheimer's mice against cognitive impairment and reduces brain beta-amyloid production.
    Arendash GW; Schleif W; Rezai-Zadeh K; Jackson EK; Zacharia LC; Cracchiolo JR; Shippy D; Tan J
    Neuroscience; 2006 Nov; 142(4):941-52. PubMed ID: 16938404
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 84.