139 related articles for article (PubMed ID: 17174996)
1. Phenylalanine(90) and phenylalanine(93) are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10.
Starlard-Davenport A; Xiong Y; Bratton S; Gallus-Zawada A; Finel M; Radominska-Pandya A
Steroids; 2007 Jan; 72(1):85-94. PubMed ID: 17174996
[TBL] [Abstract][Full Text] [Related]
2. Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin.
Miller GP; Lichti CF; Zielinska AK; Mazur A; Bratton SM; Gallus-Zawada A; Finel M; Moran JH; Radominska-Pandya A
Drug Metab Dispos; 2008 Nov; 36(11):2211-8. PubMed ID: 18725508
[TBL] [Abstract][Full Text] [Related]
3. Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis.
Xiong Y; Bernardi D; Bratton S; Ward MD; Battaglia E; Finel M; Drake RR; Radominska-Pandya A
Biochemistry; 2006 Feb; 45(7):2322-32. PubMed ID: 16475821
[TBL] [Abstract][Full Text] [Related]
4. Phenylalanine 93 of the human UGT1A10 plays a major role in the interactions of the enzyme with estrogens.
Höglund C; Sneitz N; Radominska-Pandya A; Laakonen L; Finel M
Steroids; 2011 Dec; 76(13):1465-73. PubMed ID: 21846474
[TBL] [Abstract][Full Text] [Related]
5. How many and which amino acids are responsible for the large activity differences between the highly homologous UDP-glucuronosyltransferases (UGT) 1A9 and UGT1A10?
Itäaho K; Laakkonen L; Finel M
Drug Metab Dispos; 2010 Apr; 38(4):687-96. PubMed ID: 20089735
[TBL] [Abstract][Full Text] [Related]
6. Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation.
Basu NK; Kubota S; Meselhy MR; Ciotti M; Chowdhury B; Hartori M; Owens IS
J Biol Chem; 2004 Jul; 279(27):28320-9. PubMed ID: 15117964
[TBL] [Abstract][Full Text] [Related]
7. The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis.
Xiong Y; Patana AS; Miley MJ; Zielinska AK; Bratton SM; Miller GP; Goldman A; Finel M; Redinbo MR; Radominska-Pandya A
Drug Metab Dispos; 2008 Mar; 36(3):517-22. PubMed ID: 18048489
[TBL] [Abstract][Full Text] [Related]
8. Molecular Docking-Based Design and Development of a Highly Selective Probe Substrate for UDP-glucuronosyltransferase 1A10.
Juvonen RO; Rauhamäki S; Kortet S; Niinivehmas S; Troberg J; Petsalo A; Huuskonen J; Raunio H; Finel M; Pentikäinen OT
Mol Pharm; 2018 Mar; 15(3):923-933. PubMed ID: 29421866
[TBL] [Abstract][Full Text] [Related]
9. Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.
Barre L; Fournel-Gigleux S; Finel M; Netter P; Magdalou J; Ouzzine M
FEBS J; 2007 Mar; 274(5):1256-64. PubMed ID: 17263731
[TBL] [Abstract][Full Text] [Related]
10. Mapping the UDP-glucuronic acid binding site in UDP-glucuronosyltransferase-1A10 by homology-based modeling: confirmation with biochemical evidence.
Banerjee R; Pennington MW; Garza A; Owens IS
Biochemistry; 2008 Jul; 47(28):7385-92. PubMed ID: 18570380
[TBL] [Abstract][Full Text] [Related]
11. Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform.
Dellinger RW; Fang JL; Chen G; Weinberg R; Lazarus P
Drug Metab Dispos; 2006 Jun; 34(6):943-9. PubMed ID: 16510539
[TBL] [Abstract][Full Text] [Related]
12. Glucuronidation of PhIP and N-OH-PhIP by UDP-glucuronosyltransferase 1A10.
Dellinger RW; Chen G; Blevins-Primeau AS; Krzeminski J; Amin S; Lazarus P
Carcinogenesis; 2007 Nov; 28(11):2412-8. PubMed ID: 17638922
[TBL] [Abstract][Full Text] [Related]
13. Evidence for overlapping active sites for 17 alpha-ethynlestradiol and bilirubin in the human major bilirubin UDPglucuronosyltransferase.
Ciotti M; Owens IS
Biochemistry; 1996 Aug; 35(31):10119-24. PubMed ID: 8756475
[TBL] [Abstract][Full Text] [Related]
14. Photoaffinity labeling of the aglycon binding site of the recombinant human liver UDP-glucuronosyltransferase UGT1A6 with 7-azido-4-methylcoumarin.
Senay C; Battaglia E; Chen G; Breton R; Fournel-Gigleux S; Magdalou J; Radominska-Pandya A
Arch Biochem Biophys; 1999 Aug; 368(1):75-84. PubMed ID: 10415114
[TBL] [Abstract][Full Text] [Related]
15. Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10.
Jinno H; Saeki M; Tanaka-Kagawa T; Hanioka N; Saito Y; Ozawa S; Ando M; Shirao K; Minami H; Ohtsu A; Yoshida T; Saijo N; Sawada J
Drug Metab Dispos; 2003 May; 31(5):528-32. PubMed ID: 12695339
[TBL] [Abstract][Full Text] [Related]
16. Influence of mutations associated with Gilbert and Crigler-Najjar type II syndromes on the glucuronidation kinetics of bilirubin and other UDP-glucuronosyltransferase 1A substrates.
Udomuksorn W; Elliot DJ; Lewis BC; Mackenzie PI; Yoovathaworn K; Miners JO
Pharmacogenet Genomics; 2007 Dec; 17(12):1017-29. PubMed ID: 18004206
[TBL] [Abstract][Full Text] [Related]
17. Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives.
Ritter JK; Chen F; Sheen YY; Lubet RA; Owens IS
Biochemistry; 1992 Apr; 31(13):3409-14. PubMed ID: 1554722
[TBL] [Abstract][Full Text] [Related]
18. Key amino acid residues responsible for the differences in substrate specificity of human UDP-glucuronosyltransferase (UGT)1A9 and UGT1A8.
Fujiwara R; Nakajima M; Yamanaka H; Yokoi T
Drug Metab Dispos; 2009 Jan; 37(1):41-6. PubMed ID: 18832479
[TBL] [Abstract][Full Text] [Related]
19. Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine.
Shiraga T; Yajima K; Suzuki K; Suzuki K; Hashimoto T; Iwatsubo T; Miyashita A; Usui T
Drug Metab Dispos; 2012 Feb; 40(2):276-82. PubMed ID: 22031623
[TBL] [Abstract][Full Text] [Related]
20. Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A.
Li D; Fournel-Gigleux S; Barré L; Mulliert G; Netter P; Magdalou J; Ouzzine M
J Biol Chem; 2007 Dec; 282(50):36514-24. PubMed ID: 17956868
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]