BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

379 related articles for article (PubMed ID: 17208200)

  • 1. Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.
    Wiemer AJ; Tong H; Swanson KM; Hohl RJ
    Biochem Biophys Res Commun; 2007 Feb; 353(4):921-5. PubMed ID: 17208200
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological evaluation of a series of aromatic bisphosphonates.
    Barney RJ; Wasko BM; Dudakovic A; Hohl RJ; Wiemer DF
    Bioorg Med Chem; 2010 Oct; 18(20):7212-20. PubMed ID: 20832326
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.
    Wiemer AJ; Yu JS; Lamb KM; Hohl RJ; Wiemer DF
    Bioorg Med Chem; 2008 Jan; 16(1):390-9. PubMed ID: 17905588
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation.
    Wiemer AJ; Yu JS; Shull LW; Barney RJ; Wasko BM; Lamb KM; Hohl RJ; Wiemer DF
    Bioorg Med Chem; 2008 Apr; 16(7):3652-60. PubMed ID: 18308574
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase.
    De Schutter JW; Zaretsky S; Welbourn S; Pause A; Tsantrizos YS
    Bioorg Med Chem Lett; 2010 Oct; 20(19):5781-6. PubMed ID: 20801032
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes.
    Dudakovic A; Wiemer AJ; Lamb KM; Vonnahme LA; Dietz SE; Hohl RJ
    J Pharmacol Exp Ther; 2008 Mar; 324(3):1028-36. PubMed ID: 18083912
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate.
    Wasko BM; Dudakovic A; Hohl RJ
    J Pharmacol Exp Ther; 2011 May; 337(2):540-6. PubMed ID: 21335425
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro.
    Wasko BM; Smits JP; Shull LW; Wiemer DF; Hohl RJ
    J Lipid Res; 2011 Nov; 52(11):1957-64. PubMed ID: 21903868
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.
    Coxon FP; Helfrich MH; Van't Hof R; Sebti S; Ralston SH; Hamilton A; Rogers MJ
    J Bone Miner Res; 2000 Aug; 15(8):1467-76. PubMed ID: 10934645
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase.
    Thompson K; Dunford JE; Ebetino FH; Rogers MJ
    Biochem Biophys Res Commun; 2002 Jan; 290(2):869-73. PubMed ID: 11785983
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation.
    Weivoda MM; Hohl RJ
    J Cell Biochem; 2011 Jun; 112(6):1506-13. PubMed ID: 21503955
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation.
    Agabiti SS; Li J; Wiemer AJ
    Cell Death Dis; 2017 Mar; 8(3):e2678. PubMed ID: 28300835
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration.
    Dudakovic A; Tong H; Hohl RJ
    Invest New Drugs; 2011 Oct; 29(5):912-20. PubMed ID: 20480384
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase.
    Bergstrom JD; Bostedor RG; Masarachia PJ; Reszka AA; Rodan G
    Arch Biochem Biophys; 2000 Jan; 373(1):231-41. PubMed ID: 10620343
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.
    Dunford JE; Thompson K; Coxon FP; Luckman SP; Hahn FM; Poulter CD; Ebetino FH; Rogers MJ
    J Pharmacol Exp Ther; 2001 Feb; 296(2):235-42. PubMed ID: 11160603
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors.
    Reilly JE; Zhou X; Tong H; Kuder CH; Wiemer DF; Hohl RJ
    Biochem Pharmacol; 2015 Jul; 96(2):83-92. PubMed ID: 25952057
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Nitrogen-containing bisphosphonate mechanism of action.
    Reszka AA; Rodan GA
    Mini Rev Med Chem; 2004 Sep; 4(7):711-9. PubMed ID: 15379639
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and biological activity of isoprenoid bisphosphonates.
    Shull LW; Wiemer AJ; Hohl RJ; Wiemer DF
    Bioorg Med Chem; 2006 Jun; 14(12):4130-6. PubMed ID: 16517172
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis.
    Savino S; Toscano A; Purgatorio R; Profilo E; Laghezza A; Tortorella P; Angelelli M; Cellamare S; Scala R; Tricarico D; Marobbio CMT; Perna F; Vitale P; Agamennone M; Dimiccoli V; Tolomeo A; Scilimati A
    Eur J Med Chem; 2018 Oct; 158():184-200. PubMed ID: 30216851
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of the mevalonate pathway and activation of p38 MAP kinase are independently regulated by nitrogen-containing bisphosphonates in breast cancer cells.
    Merrell MA; Wakchoure S; Lehenkari PP; Harris KW; Selander KS
    Eur J Pharmacol; 2007 Sep; 570(1-3):27-37. PubMed ID: 17640631
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.