BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

256 related articles for article (PubMed ID: 17226938)

  • 1. Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane.
    Liu L; Watanabe K; Fang Q; Williams KM; Guengerich FP; Pegg AE
    Chem Res Toxicol; 2007 Jan; 20(1):155-63. PubMed ID: 17226938
    [TBL] [Abstract][Full Text] [Related]  

  • 2. O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate.
    Liu L; Williams KM; Guengerich FP; Pegg AE
    Chem Res Toxicol; 2004 Jun; 17(6):742-52. PubMed ID: 15206895
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Function of domains of human O6-alkylguanine-DNA alkyltransferase.
    Fang Q; Kanugula S; Pegg AE
    Biochemistry; 2005 Nov; 44(46):15396-405. PubMed ID: 16285744
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
    Liu L; Hachey DL; Valadez G; Williams KM; Guengerich FP; Loktionova NA; Kanugula S; Pegg AE
    J Biol Chem; 2004 Feb; 279(6):4250-9. PubMed ID: 14645247
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine.
    Xu-Welliver M; Leitão J; Kanugula S; Pegg AE
    Cancer Res; 1999 Apr; 59(7):1514-9. PubMed ID: 10197622
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The role of human O(6)-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli.
    Liu H; Xu-Welliver M; Pegg AE
    Mutat Res; 2000 Jul; 452(1):1-10. PubMed ID: 10894884
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase.
    Valadez JG; Liu L; Loktionova NA; Pegg AE; Guengerich FP
    Chem Res Toxicol; 2004 Jul; 17(7):972-82. PubMed ID: 15257623
    [TBL] [Abstract][Full Text] [Related]  

  • 8. O6-methylguanine repair by O6-alkylguanine-DNA alkyltransferase.
    Jena NR; Shukla PK; Jena HS; Mishra PC; Suhai S
    J Phys Chem B; 2009 Dec; 113(51):16285-90. PubMed ID: 19947610
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase.
    Goodtzova K; Kanugula S; Edara S; Pegg AE
    Biochemistry; 1998 Sep; 37(36):12489-95. PubMed ID: 9730821
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants.
    Mijal RS; Thomson NM; Fleischer NL; Pauly GT; Moschel RC; Kanugula S; Fang Q; Pegg AE; Peterson LA
    Chem Res Toxicol; 2004 Mar; 17(3):424-34. PubMed ID: 15025514
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.
    Xu-Welliver M; Kanugula S; Loktionova NA; Crone TM; Pegg AE
    Biochem J; 2000 Apr; 347(Pt 2):527-34. PubMed ID: 10749683
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase.
    Spratt TE; Wu JD; Levy DE; Kanugula S; Pegg AE
    Biochemistry; 1999 May; 38(21):6801-6. PubMed ID: 10346901
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Specific labeling of O6-alkylguanine-DNA alkyltransferase by reaction with O6-(p-hydroxy[3H]methylbenzyl)guanine.
    Ciocco GM; Moschel RC; Chae MY; McLaughlin PJ; Zagon IS; Pegg AE
    Cancer Res; 1995 Sep; 55(18):4085-91. PubMed ID: 7664284
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide.
    Liu L; Xu-Welliver M; Kanugula S; Pegg AE
    Cancer Res; 2002 Jun; 62(11):3037-43. PubMed ID: 12036910
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine.
    Xu-Welliver M; Kanugula S; Pegg AE
    Cancer Res; 1998 May; 58(9):1936-45. PubMed ID: 9581836
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pyridyloxobutylation of guanine residues by 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone generates substrates of O6-alkylguanine-DNA alkyltransferase.
    Liu XK; Spratt TE; Murphy SE; Peterson LA
    Chem Res Toxicol; 1996 Sep; 9(6):949-53. PubMed ID: 8870981
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase.
    Hazra TK; Roy R; Biswas T; Grabowski DT; Pegg AE; Mitra S
    Biochemistry; 1997 May; 36(19):5769-76. PubMed ID: 9153417
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase.
    Liu L; Pegg AE; Williams KM; Guengerich FP
    J Biol Chem; 2002 Oct; 277(40):37920-8. PubMed ID: 12151404
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane.
    Loeber R; Rajesh M; Fang Q; Pegg AE; Tretyakova N
    Chem Res Toxicol; 2006 May; 19(5):645-54. PubMed ID: 16696566
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.
    Crone TM; Goodtzova K; Edara S; Pegg AE
    Cancer Res; 1994 Dec; 54(23):6221-7. PubMed ID: 7954470
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.