173 related articles for article (PubMed ID: 17254782)
1. Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors.
Carato P; Graulich A; Jensen N; Roth BL; Liégeois JF
Bioorg Med Chem Lett; 2007 Mar; 17(6):1565-9. PubMed ID: 17254782
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors.
Carato P; Graulich A; Jensen N; Roth BL; Liégeois JF
Bioorg Med Chem Lett; 2007 Mar; 17(6):1570-4. PubMed ID: 17251022
[TBL] [Abstract][Full Text] [Related]
3. New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.
Liégeois JF; Eyrolles L; Ellenbroek BA; Lejeune C; Carato P; Bruhwyler J; Géczy J; Damas J; Delarge J
J Med Chem; 2002 Nov; 45(23):5136-49. PubMed ID: 12408724
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.
Hirokawa Y; Fujiwara I; Suzuki K; Harada H; Yoshikawa T; Yoshida N; Kato S
J Med Chem; 2003 Feb; 46(5):702-15. PubMed ID: 12593651
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and in vitro binding studies of piperazine-alkyl-naphthamides: impact of homology and sulphonamide/carboxamide bioisosteric replacement on the affinity for 5-HT1A, alpha2A, D4.2, D3 and D2L receptors.
Résimont M; Liégeois JF
Bioorg Med Chem Lett; 2010 Sep; 20(17):5199-202. PubMed ID: 20656482
[TBL] [Abstract][Full Text] [Related]
6. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics.
Bojarski AJ; Paluchowska MH; Duszyńska B; Kłodzińska A; Tatarczyńska E; Chojnacka-Wójcik E
Bioorg Med Chem; 2005 Mar; 13(6):2293-303. PubMed ID: 15727878
[TBL] [Abstract][Full Text] [Related]
7. New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor.
Macchia M; Cervetto L; Demontis GC; Longoni B; Minutolo F; Orlandini E; Ortore G; Papi C; Sbrana A; Macchia B
J Med Chem; 2003 Jan; 46(1):161-8. PubMed ID: 12502370
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.
Huang Y; Luedtke RR; Freeman RA; Wu L; Mach RH
J Med Chem; 2001 May; 44(11):1815-26. PubMed ID: 11356115
[TBL] [Abstract][Full Text] [Related]
9. 1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.
Carling RW; Moore KW; Moyes CR; Jones EA; Bonner K; Emms F; Marwood R; Patel S; Patel S; Fletcher AE; Beer M; Sohal B; Pike A; Leeson PD
J Med Chem; 1999 Jul; 42(14):2706-15. PubMed ID: 10411491
[TBL] [Abstract][Full Text] [Related]
10. Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
Frølund B; Jensen LS; Guandalini L; Canillo C; Vestergaard HT; Kristiansen U; Nielsen B; Stensbøl TB; Madsen C; Krogsgaard-Larsen P; Liljefors T
J Med Chem; 2005 Jan; 48(2):427-39. PubMed ID: 15658856
[TBL] [Abstract][Full Text] [Related]
11. N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and receptor binding studies.
Cervetto L; Demontis GC; Giannaccini G; Longoni B; Macchia B; Macchia M; Martinelli A; Orlandini E
J Med Chem; 1998 Dec; 41(25):4933-8. PubMed ID: 9836610
[TBL] [Abstract][Full Text] [Related]
12. 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.
Rowley M; Collins I; Broughton HB; Davey WB; Baker R; Emms F; Marwood R; Patel S; Patel S; Ragan CI; Freedman SB; Ball R; Leeson PD
J Med Chem; 1997 Jul; 40(15):2374-85. PubMed ID: 9240352
[TBL] [Abstract][Full Text] [Related]
13. Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.
Zajdel P; Subra G; Bojarski AJ; Duszyńska B; Tatarczyńska E; Nikiforuk A; Chojnacka-Wójcik E; Pawłowski M; Martinez J
Bioorg Med Chem; 2007 Apr; 15(8):2907-19. PubMed ID: 17321139
[TBL] [Abstract][Full Text] [Related]
14. Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.
Raviña E; Casariego I; Masaguer CF; Fontenla JA; Montenegro GY; Rivas ME; Loza MI; Enguix MJ; Villazon M; Cadavid MI; Demontis GC
J Med Chem; 2000 Nov; 43(24):4678-93. PubMed ID: 11101359
[TBL] [Abstract][Full Text] [Related]
15. New potent 5-HT(2A) receptor ligands containing an N'-cyanopicolinamidine nucleus: Synthesis and in vitro pharmacological evaluation.
Fiorino F; Severino B; Magli E; Perissutti E; Frecentese F; Esposito A; Incisivo GM; Ciano A; Massarelli P; Nencini C; Santagada V; Caliendo G
Eur J Med Chem; 2012 Jan; 47(1):520-9. PubMed ID: 22133459
[TBL] [Abstract][Full Text] [Related]
16. N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor.
Arora J; Bordeleau M; Dube L; Jarvie K; Mazzocco L; Peragine J; Tehim A; Egle I
Bioorg Med Chem Lett; 2005 Dec; 15(23):5253-6. PubMed ID: 16168646
[TBL] [Abstract][Full Text] [Related]
17. Position 5.46 of the serotonin 5-HT2A receptor contributes to a species-dependent variation for the 5-HT2C agonist (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: impact on selectivity and toxicological evaluation.
Miller KJ; Wu GY; Varnes JG; Levesque P; Li J; Li D; Robl JA; Rossi KA; Wacker DA
Mol Pharmacol; 2009 Dec; 76(6):1211-9. PubMed ID: 19767451
[TBL] [Abstract][Full Text] [Related]
18. N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.
Liu Z; Chen X; Sun P; Yu L; Zhen X; Zhang A
Bioorg Med Chem; 2008 Sep; 16(18):8335-8. PubMed ID: 18783955
[TBL] [Abstract][Full Text] [Related]
19. S33138 [N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]-benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent: I. Receptor-binding profile and functional actions at G-protein-coupled receptors.
Millan MJ; Mannoury la Cour C; Novi F; Maggio R; Audinot V; Newman-Tancredi A; Cussac D; Pasteau V; Boutin JA; Dubuffet T; Lavielle G
J Pharmacol Exp Ther; 2008 Feb; 324(2):587-99. PubMed ID: 18024789
[TBL] [Abstract][Full Text] [Related]
20. 1-cinnamyl-4-(2-methoxyphenyl)piperazines: synthesis, binding properties, and docking to dopamine (D(2)) and serotonin (5-HT(1A)) receptors.
Penjisević J; Sukalović V; Andrić D; Kostić-Rajacić S; Soskić V; Roglić G
Arch Pharm (Weinheim); 2007 Sep; 340(9):456-65. PubMed ID: 17763374
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
