132 related articles for article (PubMed ID: 17269759)
1. Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.
Slater MJ; Amphlett EM; Andrews DM; Bravi G; Burton G; Cheasty AG; Corfield JA; Ellis MR; Fenwick RH; Fernandes S; Guidetti R; Haigh D; Hartley CD; Howes PD; Jackson DL; Jarvest RL; Lovegrove VL; Medhurst KJ; Parry NR; Price H; Shah P; Singh OM; Stocker R; Thommes P; Wilkinson C; Wonacott A
J Med Chem; 2007 Mar; 50(5):897-900. PubMed ID: 17269759
[TBL] [Abstract][Full Text] [Related]
2. 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Tedesco R; Shaw AN; Bambal R; Chai D; Concha NO; Darcy MG; Dhanak D; Fitch DM; Gates A; Gerhardt WG; Halegoua DL; Han C; Hofmann GA; Johnston VK; Kaura AC; Liu N; Keenan RM; Lin-Goerke J; Sarisky RT; Wiggall KJ; Zimmerman MN; Duffy KJ
J Med Chem; 2006 Feb; 49(3):971-83. PubMed ID: 16451063
[TBL] [Abstract][Full Text] [Related]
3. Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture.
Burton G; Ku TW; Carr TJ; Kiesow T; Sarisky RT; Lin-Goerke J; Baker A; Earnshaw DL; Hofmann GA; Keenan RM; Dhanak D
Bioorg Med Chem Lett; 2005 Mar; 15(6):1553-6. PubMed ID: 15745795
[TBL] [Abstract][Full Text] [Related]
4. Identification of novel HCV RNA-dependent RNA polymerase inhibitors using pharmacophore-guided virtual screening.
Kim J; Kim KS; Kim DE; Chong Y
Chem Biol Drug Des; 2008 Dec; 72(6):585-91. PubMed ID: 19090925
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.
Randolph JT; Flentge CA; Huang PP; Hutchinson DK; Klein LL; Lim HB; Mondal R; Reisch T; Montgomery DA; Jiang WW; Masse SV; Hernandez LE; Henry RF; Liu Y; Koev G; Kati WM; Stewart KD; Beno DW; Molla A; Kempf DJ
J Med Chem; 2009 May; 52(10):3174-83. PubMed ID: 19402666
[TBL] [Abstract][Full Text] [Related]
6. Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease.
Slater MJ; Amphlett EM; Andrews DM; Bamborough P; Carey SJ; Johnson MR; Jones PS; Mills G; Parry NR; Somers DO; Stewart AJ; Skarzynski T
Org Lett; 2003 Nov; 5(24):4627-30. PubMed ID: 14627400
[TBL] [Abstract][Full Text] [Related]
7. A highly efficient, asymmetric synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Fitch DM; Evans KA; Chai D; Duffy KJ
Org Lett; 2005 Nov; 7(24):5521-4. PubMed ID: 16288546
[TBL] [Abstract][Full Text] [Related]
8. Potent inhibitors of the hepatitis C virus NS3 protease: use of a novel P2 cyclopentane-derived template.
Johansson PO; Bäck M; Kvarnström I; Jansson K; Vrang L; Hamelink E; Hallberg A; Rosenquist A; Samuelsson B
Bioorg Med Chem; 2006 Aug; 14(15):5136-51. PubMed ID: 16675222
[TBL] [Abstract][Full Text] [Related]
9. Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.
Venkatraman S; Velazquez F; Gavalas S; Wu W; Chen KX; Nair AG; Bennett F; Huang Y; Pinto P; Jiang Y; Selyutin O; Vibulbhan B; Zeng Q; Lesburg C; Duca J; Huang HC; Agrawal S; Jiang CK; Ferrari E; Li C; Kozlowski J; Rosenblum S; Shih NY; Njoroge FG
Bioorg Med Chem; 2013 Apr; 21(7):2007-17. PubMed ID: 23434368
[TBL] [Abstract][Full Text] [Related]
10. Simple but highly effective three-dimensional chemical-feature-based pharmacophore model for diketo acid derivatives as hepatitis C virus RNA-dependent RNA polymerase inhibitors.
Di Santo R; Fermeglia M; Ferrone M; Paneni MS; Costi R; Artico M; Roux A; Gabriele M; Tardif KD; Siddiqui A; Pricl S
J Med Chem; 2005 Oct; 48(20):6304-14. PubMed ID: 16190757
[TBL] [Abstract][Full Text] [Related]
11. Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase.
Delang L; Froeyen M; Herdewijn P; Neyts J
Antiviral Res; 2012 Jan; 93(1):30-8. PubMed ID: 22033247
[TBL] [Abstract][Full Text] [Related]
12. Human immunodeficiency virus-reverse transcriptase inhibition and hepatitis C virus RNA-dependent RNA polymerase inhibition activities of fullerene derivatives.
Mashino T; Shimotohno K; Ikegami N; Nishikawa D; Okuda K; Takahashi K; Nakamura S; Mochizuki M
Bioorg Med Chem Lett; 2005 Feb; 15(4):1107-9. PubMed ID: 15686922
[TBL] [Abstract][Full Text] [Related]
13. A homogeneous, solid-phase assay for hepatitis C virus RNA-dependent RNA polymerase.
Wang YK; Rigat KL; Roberts SB; Gao M
Anal Biochem; 2006 Dec; 359(1):106-11. PubMed ID: 17054898
[TBL] [Abstract][Full Text] [Related]
14. Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.
Perrone P; Luoni GM; Kelleher MR; Daverio F; Angell A; Mulready S; Congiatu C; Rajyaguru S; Martin JA; Levêque V; Le Pogam S; Najera I; Klumpp K; Smith DB; McGuigan C
J Med Chem; 2007 Apr; 50(8):1840-9. PubMed ID: 17367121
[TBL] [Abstract][Full Text] [Related]
15. An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
Evans KA; Chai D; Graybill TL; Burton G; Sarisky RT; Lin-Goerke J; Johnston VK; Rivero RA
Bioorg Med Chem Lett; 2006 Apr; 16(8):2205-8. PubMed ID: 16455253
[TBL] [Abstract][Full Text] [Related]
16. Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings.
Chen KX; Vibulbhan B; Yang W; Nair LG; Tong X; Cheng KC; Njoroge FG
Bioorg Med Chem Lett; 2009 Feb; 19(4):1105-9. PubMed ID: 19168351
[TBL] [Abstract][Full Text] [Related]
17. Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics.
Perni RB; Chandorkar G; Cottrell KM; Gates CA; Lin C; Lin K; Luong YP; Maxwell JP; Murcko MA; Pitlik J; Rao G; Schairer WC; Van Drie J; Wei Y
Bioorg Med Chem Lett; 2007 Jun; 17(12):3406-11. PubMed ID: 17482818
[TBL] [Abstract][Full Text] [Related]
18. Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.
Maring CJ; Stoll VS; Zhao C; Sun M; Krueger AC; Stewart KD; Madigan DL; Kati WM; Xu Y; Carrick RJ; Montgomery DA; Kempf-Grote A; Marsh KC; Molla A; Steffy KR; Sham HL; Laver WG; Gu YG; Kempf DJ; Kohlbrenner WE
J Med Chem; 2005 Jun; 48(12):3980-90. PubMed ID: 15943472
[TBL] [Abstract][Full Text] [Related]
19. The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.
Smith DB; Kalayanov G; Sund C; Winqvist A; Pinho P; Maltseva T; Morisson V; Leveque V; Rajyaguru S; Le Pogam S; Najera I; Benkestock K; Zhou XX; Maag H; Cammack N; Martin JA; Swallow S; Johansson NG; Klumpp K; Smith M
J Med Chem; 2009 Jan; 52(1):219-23. PubMed ID: 19055482
[TBL] [Abstract][Full Text] [Related]
20. Binding-site identification and genotypic profiling of hepatitis C virus polymerase inhibitors.
Pauwels F; Mostmans W; Quirynen LM; van der Helm L; Boutton CW; Rueff AS; Cleiren E; Raboisson P; Surleraux D; Nyanguile O; Simmen KA
J Virol; 2007 Jul; 81(13):6909-19. PubMed ID: 17459932
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]