BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

218 related articles for article (PubMed ID: 17274942)

  • 1. Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W.
    Fernando H; Davydov DR; Chin CC; Halpert JR
    Arch Biochem Biophys; 2007 Apr; 460(1):129-40. PubMed ID: 17274942
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.
    Domanski TL; He YA; Harlow GR; Halpert JR
    J Pharmacol Exp Ther; 2000 May; 293(2):585-91. PubMed ID: 10773032
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration.
    Fernando H; Halpert JR; Davydov DR
    Biochemistry; 2006 Apr; 45(13):4199-209. PubMed ID: 16566594
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics.
    Harlow GR; Halpert JR
    Proc Natl Acad Sci U S A; 1998 Jun; 95(12):6636-41. PubMed ID: 9618464
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity.
    Fernando H; Rumfeldt JA; Davydova NY; Halpert JR; Davydov DR
    Xenobiotica; 2011 Apr; 41(4):281-9. PubMed ID: 21143007
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Allosteric mechanisms in cytochrome P450 3A4 studied by high-pressure spectroscopy: pivotal role of substrate-induced changes in the accessibility and degree of hydration of the heme pocket.
    Davydov DR; Baas BJ; Sligar SG; Halpert JR
    Biochemistry; 2007 Jul; 46(26):7852-64. PubMed ID: 17555301
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Elucidation of distinct ligand binding sites for cytochrome P450 3A4.
    Hosea NA; Miller GP; Guengerich FP
    Biochemistry; 2000 May; 39(20):5929-39. PubMed ID: 10821664
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Influence of P450 3A4 SRS-2 residues on cooperativity and/or regioselectivity of aflatoxin B(1) oxidation.
    Xue L; Wang HF; Wang Q; Szklarz GD; Domanski TL; Halpert JR; Correia MA
    Chem Res Toxicol; 2001 May; 14(5):483-91. PubMed ID: 11368545
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5.
    Yamazaki H; Johnson WW; Ueng YF; Shimada T; Guengerich FP
    J Biol Chem; 1996 Nov; 271(44):27438-44. PubMed ID: 8910324
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.
    Isin EM; Guengerich FP
    J Biol Chem; 2006 Apr; 281(14):9127-36. PubMed ID: 16467307
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study.
    Khan KK; Liu H; Halpert JR
    Drug Metab Dispos; 2003 Apr; 31(4):356-9. PubMed ID: 12642459
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.
    Tsalkova TN; Davydova NY; Halpert JR; Davydov DR
    Biochemistry; 2007 Jan; 46(1):106-19. PubMed ID: 17198380
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase.
    Yamazaki H; Shimada T; Martin MV; Guengerich FP
    J Biol Chem; 2001 Aug; 276(33):30885-91. PubMed ID: 11413149
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps.
    Krauser JA; Guengerich FP
    J Biol Chem; 2005 May; 280(20):19496-506. PubMed ID: 15772082
    [TBL] [Abstract][Full Text] [Related]  

  • 15. An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.
    Davydov DR; Botchkareva AE; Kumar S; He YQ; Halpert JR
    Biochemistry; 2004 Jun; 43(21):6475-85. PubMed ID: 15157081
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein.
    Lin HL; Kent UM; Hollenberg PF
    J Pharmacol Exp Ther; 2002 Apr; 301(1):160-7. PubMed ID: 11907170
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450.
    Davydov DR; Fernando H; Halpert JR
    Biophys Chem; 2006 Sep; 123(2-3):95-101. PubMed ID: 16701937
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cooperativity in oxidations catalyzed by cytochrome P450 3A4.
    Ueng YF; Kuwabara T; Chun YJ; Guengerich FP
    Biochemistry; 1997 Jan; 36(2):370-81. PubMed ID: 9003190
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate.
    Davydov DR; Kumar S; Halpert JR
    Biochem Biophys Res Commun; 2002 Jun; 294(4):806-12. PubMed ID: 12061778
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Interaction of apo-cytochrome b5 with cytochromes P4503A4 and P45017A: relevance of heme transfer reactions.
    Guryev OL; Gilep AA; Usanov SA; Estabrook RW
    Biochemistry; 2001 Apr; 40(16):5018-31. PubMed ID: 11305918
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.