BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

572 related articles for article (PubMed ID: 17275735)

  • 1. Scaffold selection and scaffold hopping in lead generation: a medicinal chemistry perspective.
    Zhao H
    Drug Discov Today; 2007 Feb; 12(3-4):149-55. PubMed ID: 17275735
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Fragments, network biology and designing multiple ligands.
    Morphy R; Rankovic Z
    Drug Discov Today; 2007 Feb; 12(3-4):156-60. PubMed ID: 17275736
    [TBL] [Abstract][Full Text] [Related]  

  • 3. From modeling to medicinal chemistry: automatic generation of two-dimensional complex diagrams.
    Stierand K; Rarey M
    ChemMedChem; 2007 Jun; 2(6):853-60. PubMed ID: 17436259
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Novel 2D fingerprints for ligand-based virtual screening.
    Ewing T; Baber JC; Feher M
    J Chem Inf Model; 2006; 46(6):2423-31. PubMed ID: 17125184
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Affinity-based screening techniques for enhancing lead discovery.
    Comess KM; Schurdak ME
    Curr Opin Drug Discov Devel; 2004 Jul; 7(4):411-6. PubMed ID: 15338950
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Strategies and tactics for optimizing the Hit-to-Lead process and beyond--a computational chemistry perspective.
    Manly CJ; Chandrasekhar J; Ochterski JW; Hammer JD; Warfield BB
    Drug Discov Today; 2008 Feb; 13(3-4):99-109. PubMed ID: 18275907
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Towards improving compound selection in structure-based virtual screening.
    Waszkowycz B
    Drug Discov Today; 2008 Mar; 13(5-6):219-26. PubMed ID: 18342797
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Calculation and application of activity discriminants in lead optimization.
    Luo X; Krumrine JR; Shenvi AB; Pierson ME; Bernstein PR
    J Mol Graph Model; 2010 Nov; 29(3):372-81. PubMed ID: 20800520
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A knowledge-based weighting approach to ligand-based virtual screening.
    Stiefl N; Zaliani A
    J Chem Inf Model; 2006; 46(2):587-96. PubMed ID: 16562987
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Recent developments in de novo design and scaffold hopping.
    Mauser H; Guba W
    Curr Opin Drug Discov Devel; 2008 May; 11(3):365-74. PubMed ID: 18428090
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Scaffold composition and biological relevance of screening libraries.
    Shelat AA; Guy RK
    Nat Chem Biol; 2007 Aug; 3(8):442-6. PubMed ID: 17637770
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Integrating virtual screening in lead discovery.
    Oprea TI; Matter H
    Curr Opin Chem Biol; 2004 Aug; 8(4):349-58. PubMed ID: 15288243
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Image-based chemical screening.
    Carpenter AE
    Nat Chem Biol; 2007 Aug; 3(8):461-5. PubMed ID: 17637778
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Medicinal chemistry inspired fragment-based drug discovery.
    Lanter J; Zhang X; Sui Z
    Methods Enzymol; 2011; 493():421-45. PubMed ID: 21371600
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2).
    Ulmschneider S; Negri M; Voets M; Hartmann RW
    Bioorg Med Chem Lett; 2006 Jan; 16(1):25-30. PubMed ID: 16246562
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Metal complexes in medicinal chemistry: new vistas and challenges in drug design.
    Thompson KH; Orvig C
    Dalton Trans; 2006 Feb; (6):761-4. PubMed ID: 16437168
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation.
    Badarau E; Suzenet F; Bojarski AJ; Fînaru AL; Guillaumet G
    Bioorg Med Chem Lett; 2009 Mar; 19(6):1600-3. PubMed ID: 19237285
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Lead optimization strategies as part of a drug metabolism environment.
    Korfmacher WA
    Curr Opin Drug Discov Devel; 2003 Jul; 6(4):481-5. PubMed ID: 12951811
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Applications of high-throughput ADME in drug discovery.
    Kassel DB
    Curr Opin Chem Biol; 2004 Jun; 8(3):339-45. PubMed ID: 15183334
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Fragment-based drug design: combining philosophy with technology.
    Bartoli S; Fincham CI; Fattori D
    Curr Opin Drug Discov Devel; 2007 Jul; 10(4):422-9. PubMed ID: 17659483
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 29.