BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

238 related articles for article (PubMed ID: 17292621)

  • 1. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents.
    Imbimbo BP; Del Giudice E; Cenacchi V; Volta R; Villetti G; Facchinetti F; Riccardi B; Puccini P; Moretto N; Grassi F; Ottonello S; Leon A
    Pharmacol Res; 2007 Apr; 55(4):318-28. PubMed ID: 17292621
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity.
    Imbimbo BP; Del Giudice E; Colavito D; D'Arrigo A; Dalle Carbonare M; Villetti G; Facchinetti F; Volta R; Pietrini V; Baroc MF; Serneels L; De Strooper B; Leon A
    J Pharmacol Exp Ther; 2007 Dec; 323(3):822-30. PubMed ID: 17895400
    [TBL] [Abstract][Full Text] [Related]  

  • 3. CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid.
    Porrini V; Lanzillotta A; Branca C; Benarese M; Parrella E; Lorenzini L; Calzà L; Flaibani R; Spano PF; Imbimbo BP; Pizzi M
    Neuroscience; 2015 Aug; 302():112-20. PubMed ID: 25450955
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.
    Imbimbo BP; Hutter-Paier B; Villetti G; Facchinetti F; Cenacchi V; Volta R; Lanzillotta A; Pizzi M; Windisch M
    Br J Pharmacol; 2009 Mar; 156(6):982-93. PubMed ID: 19239474
    [TBL] [Abstract][Full Text] [Related]  

  • 5. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.
    Eriksen JL; Sagi SA; Smith TE; Weggen S; Das P; McLendon DC; Ozols VV; Jessing KW; Zavitz KH; Koo EH; Golde TE
    J Clin Invest; 2003 Aug; 112(3):440-9. PubMed ID: 12897211
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice.
    Sivilia S; Lorenzini L; Giuliani A; Gusciglio M; Fernandez M; Baldassarro VA; Mangano C; Ferraro L; Pietrini V; Baroc MF; Viscomi AR; Ottonello S; Villetti G; Imbimbo BP; Calzà L; Giardino L
    BMC Neurosci; 2013 Apr; 14():44. PubMed ID: 23560952
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.
    Kukar T; Prescott S; Eriksen JL; Holloway V; Murphy MP; Koo EH; Golde TE; Nicolle MM
    BMC Neurosci; 2007 Jul; 8():54. PubMed ID: 17650315
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.
    Lanzillotta A; Sarnico I; Benarese M; Branca C; Baiguera C; Hutter-Paier B; Windisch M; Spano P; Imbimbo BP; Pizzi M
    J Mol Neurosci; 2011 Sep; 45(1):22-31. PubMed ID: 21181298
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.
    Peretto I; Radaelli S; Parini C; Zandi M; Raveglia LF; Dondio G; Fontanella L; Misiano P; Bigogno C; Rizzi A; Riccardi B; Biscaioli M; Marchetti S; Puccini P; Catinella S; Rondelli I; Cenacchi V; Bolzoni PT; Caruso P; Villetti G; Facchinetti F; Del Giudice E; Moretto N; Imbimbo BP
    J Med Chem; 2005 Sep; 48(18):5705-20. PubMed ID: 16134939
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
    Stock N; Munoz B; Wrigley JD; Shearman MS; Beher D; Peachey J; Williamson TL; Bain G; Chen W; Jiang X; St-Jacques R; Prasit P
    Bioorg Med Chem Lett; 2006 Apr; 16(8):2219-23. PubMed ID: 16455248
    [TBL] [Abstract][Full Text] [Related]  

  • 11. CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice.
    Beggiato S; Giuliani A; Sivilia S; Lorenzini L; Antonelli T; Imbimbo BP; Giardino L; Calzà L; Ferraro L
    Neuroscience; 2014 Apr; 266():13-22. PubMed ID: 24530449
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.
    Balducci C; Mehdawy B; Mare L; Giuliani A; Lorenzini L; Sivilia S; Giardino L; Calzà L; Lanzillotta A; Sarnico I; Pizzi M; Usiello A; Viscomi AR; Ottonello S; Villetti G; Imbimbo BP; Nisticò G; Forloni G; Nisticò R
    J Alzheimers Dis; 2011; 24(4):799-816. PubMed ID: 21321397
    [TBL] [Abstract][Full Text] [Related]  

  • 13. CHF5074 protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro.
    Ronsisvalle N; Di Benedetto G; Parenti C; Amoroso S; Bernardini R; Cantarella G
    Curr Alzheimer Res; 2014; 11(7):714-24. PubMed ID: 24938499
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selective inhibition of Abeta42 production by NSAID R-enantiomers.
    Morihara T; Chu T; Ubeda O; Beech W; Cole GM
    J Neurochem; 2002 Nov; 83(4):1009-12. PubMed ID: 12421374
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Retinoid X receptor-alpha mediates (R )-flurbiprofen's effect on the levels of Alzheimer's beta-amyloid.
    You X; Zhang YW; Chen Y; Huang X; Xu R; Cao X; Chen J; Liu Y; Zhang X; Xu H
    J Neurochem; 2009 Oct; 111(1):142-9. PubMed ID: 19659691
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.
    Weggen S; Eriksen JL; Das P; Sagi SA; Wang R; Pietrzik CU; Findlay KA; Smith TE; Murphy MP; Bulter T; Kang DE; Marquez-Sterling N; Golde TE; Koo EH
    Nature; 2001 Nov; 414(6860):212-6. PubMed ID: 11700559
    [TBL] [Abstract][Full Text] [Related]  

  • 17. CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease.
    Imbimbo BP; Giardino L; Sivilia S; Giuliani A; Gusciglio M; Pietrini V; Del Giudice E; D'Arrigo A; Leon A; Villetti G; Calzà L
    J Alzheimers Dis; 2010; 20(1):159-73. PubMed ID: 20164581
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pharmacological targeting of the β-amyloid precursor protein intracellular domain.
    Branca C; Sarnico I; Ruotolo R; Lanzillotta A; Viscomi AR; Benarese M; Porrini V; Lorenzini L; Calzà L; Imbimbo BP; Ottonello S; Pizzi M
    Sci Rep; 2014 Apr; 4():4618. PubMed ID: 24714650
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives.
    Lichtenstein MP; Carriba P; Baltrons MA; Wojciak-Stothard B; Peterson JR; García A; Galea E
    J Alzheimers Dis; 2010; 22(4):1135-55. PubMed ID: 20930267
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Aging Enables Ca2+ Overload and Apoptosis Induced by Amyloid-β Oligomers in Rat Hippocampal Neurons: Neuroprotection by Non-Steroidal Anti-Inflammatory Drugs and R-Flurbiprofen in Aging Neurons.
    Calvo-Rodríguez M; García-Durillo M; Villalobos C; Núñez L
    J Alzheimers Dis; 2016 Jul; 54(1):207-21. PubMed ID: 27447424
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.