BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

176 related articles for article (PubMed ID: 17297914)

  • 1. Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors.
    Lovelace LL; Gibson LM; Lebioda L
    Biochemistry; 2007 Mar; 46(10):2823-30. PubMed ID: 17297914
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles.
    Luo B; Repalli J; Yousef AM; Johnson SR; Lebioda L; Berger SH
    Protein Sci; 2011 Jan; 20(1):87-94. PubMed ID: 21064161
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach.
    El-Mesallamy HO; El Magdoub HM; Chapman JM; Hamdy NM; Schaalan MF; Hammad LN; Berger SH
    PLoS One; 2018; 13(3):e0193810. PubMed ID: 29538414
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states.
    Chen D; Jansson A; Sim D; Larsson A; Nordlund P
    J Biol Chem; 2017 Aug; 292(32):13449-13458. PubMed ID: 28634233
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.
    Stout TJ; Stroud RM
    Structure; 1996 Jan; 4(1):67-77. PubMed ID: 8805515
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
    Phan J; Steadman DJ; Koli S; Ding WC; Minor W; Dunlap RB; Berger SH; Lebioda L
    J Biol Chem; 2001 Apr; 276(17):14170-7. PubMed ID: 11278511
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity.
    Rutenber EE; Stroud RM
    Structure; 1996 Nov; 4(11):1317-24. PubMed ID: 8939755
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.
    Phan J; Koli S; Minor W; Dunlap RB; Berger SH; Lebioda L
    Biochemistry; 2001 Feb; 40(7):1897-902. PubMed ID: 11329255
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits.
    Anderson AC; O'Neil RH; DeLano WL; Stroud RM
    Biochemistry; 1999 Oct; 38(42):13829-36. PubMed ID: 10529228
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
    Spencer HT; Villafranca JE; Appleman JR
    Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.
    Strop P; Changchien L; Maley F; Montfort WR
    Protein Sci; 1997 Dec; 6(12):2504-11. PubMed ID: 9416600
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .
    Huang X; Gibson LM; Bell BJ; Lovelace LL; Peña MM; Berger FG; Berger SH; Lebioda L
    Biochemistry; 2010 Mar; 49(11):2475-82. PubMed ID: 20151707
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity.
    Sotelo-Mundo RR; Changchien L; Maley F; Montfort WR
    J Biochem Mol Toxicol; 2006; 20(2):88-92. PubMed ID: 16615077
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystal structure of the active form of native human thymidylate synthase in the absence of bound substrates.
    Deschamps P; Réty S; Bareille J; Leulliot N
    Acta Crystallogr F Struct Biol Commun; 2017 Jun; 73(Pt 6):336-341. PubMed ID: 28580921
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase.
    Berger SH; Berger FG; Lebioda L
    Biochim Biophys Acta; 2004 Jan; 1696(1):15-22. PubMed ID: 14726200
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
    Almog R; Waddling CA; Maley F; Maley GF; Van Roey P
    Protein Sci; 2001 May; 10(5):988-96. PubMed ID: 11316879
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase.
    Bonin JP; Sapienza PJ; Wilkerson E; Goldfarb D; Wang L; Herring L; Chen X; Major MB; Lee AL
    Biophys J; 2019 Sep; 117(6):1074-1084. PubMed ID: 31500803
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors.
    Pozzi C; Ferrari S; Luciani R; Costi MP; Mangani S
    Molecules; 2019 Apr; 24(7):. PubMed ID: 30959951
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism.
    Kamb A; Finer-Moore JS; Stroud RM
    Biochemistry; 1992 Dec; 31(51):12876-84. PubMed ID: 1281428
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase.
    Ward WH; Kimbell R; Jackman AL
    Biochem Pharmacol; 1992 May; 43(9):2029-31. PubMed ID: 1596289
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.