259 related articles for article (PubMed ID: 17298034)
1. Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.
Bender RP; Ham AJ; Osheroff N
Biochemistry; 2007 Mar; 46(10):2856-64. PubMed ID: 17298034
[TBL] [Abstract][Full Text] [Related]
2. Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.
Bender RP; Osheroff N
Chem Res Toxicol; 2007 Jun; 20(6):975-81. PubMed ID: 17516663
[TBL] [Abstract][Full Text] [Related]
3. Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.
Bender RP; Lehmler HJ; Robertson LW; Ludewig G; Osheroff N
Biochemistry; 2006 Aug; 45(33):10140-52. PubMed ID: 16906772
[TBL] [Abstract][Full Text] [Related]
4. Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα.
Vann KR; Ekiz G; Zencir S; Bedir E; Topcu Z; Osheroff N
Chem Res Toxicol; 2016 Mar; 29(3):415-20. PubMed ID: 26894873
[TBL] [Abstract][Full Text] [Related]
5. Two-Mechanism Model for the Interaction of Etoposide Quinone with Topoisomerase IIα.
Gibson EG; King MM; Mercer SL; Deweese JE
Chem Res Toxicol; 2016 Sep; 29(9):1541-8. PubMed ID: 27533850
[TBL] [Abstract][Full Text] [Related]
6. Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism.
Lindsey RH; Pendleton M; Ashley RE; Mercer SL; Deweese JE; Osheroff N
Biochemistry; 2014 Oct; 53(41):6595-602. PubMed ID: 25280269
[TBL] [Abstract][Full Text] [Related]
7. Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites.
Lindsey RH; Bender RP; Osheroff N
Chem Biol Interact; 2005 May; 153-154():197-205. PubMed ID: 15935817
[TBL] [Abstract][Full Text] [Related]
8. Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα.
Infante Lara L; Sledge A; Laradji A; Okoro CO; Osheroff N
Bioorg Med Chem Lett; 2017 Feb; 27(3):586-589. PubMed ID: 27998679
[TBL] [Abstract][Full Text] [Related]
9. Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα.
Ashley RE; Osheroff N
Chem Res Toxicol; 2014 May; 27(5):787-93. PubMed ID: 24650156
[TBL] [Abstract][Full Text] [Related]
10. Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme.
Dickey JS; Osheroff N
Biochemistry; 2005 Aug; 44(34):11546-54. PubMed ID: 16114891
[TBL] [Abstract][Full Text] [Related]
11. Etoposide quinone is a redox-dependent topoisomerase II poison.
Jacob DA; Mercer SL; Osheroff N; Deweese JE
Biochemistry; 2011 Jun; 50(25):5660-7. PubMed ID: 21595477
[TBL] [Abstract][Full Text] [Related]
12. Examination of the Impact of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα.
Wilson JT; Jiang X; McGill BC; Lisic EC; Deweese JE
Chem Res Toxicol; 2016 Apr; 29(4):649-58. PubMed ID: 26982206
[TBL] [Abstract][Full Text] [Related]
13. Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening.
Drwal MN; Marinello J; Manzo SG; Wakelin LP; Capranico G; Griffith R
PLoS One; 2014; 9(12):e114904. PubMed ID: 25489853
[TBL] [Abstract][Full Text] [Related]
14. Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain.
McClendon AK; Gentry AC; Dickey JS; Brinch M; Bendsen S; Andersen AH; Osheroff N
Biochemistry; 2008 Dec; 47(50):13169-78. PubMed ID: 19053267
[TBL] [Abstract][Full Text] [Related]
15. Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha.
Deweese JE; Guengerich FP; Burgin AB; Osheroff N
Biochemistry; 2009 Sep; 48(38):8940-7. PubMed ID: 19697956
[TBL] [Abstract][Full Text] [Related]
16. Transfection of 9-hydroxyellipticine-resistant Chinese hamster fibroblasts with human topoisomerase IIalpha cDNA: selective restoration of the sensitivity to DNA religation inhibitors.
Khélifa T; René B; Le Mée S; Lambert B; Saucier JM; Markovits J; Jacquemin-Sablon H; Jacquemin-Sablon A
Cancer Res; 1999 Oct; 59(19):4927-36. PubMed ID: 10519406
[TBL] [Abstract][Full Text] [Related]
17. Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.
Sehested M; Wessel I; Jensen LH; Holm B; Oliveri RS; Kenwrick S; Creighton AM; Nitiss JL; Jensen PB
Cancer Res; 1998 Apr; 58(7):1460-8. PubMed ID: 9537249
[TBL] [Abstract][Full Text] [Related]
18. Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions.
Aldred KJ; Schwanz HA; Li G; McPherson SA; Turnbough CL; Kerns RJ; Osheroff N
ACS Chem Biol; 2013 Dec; 8(12):2660-8. PubMed ID: 24047414
[TBL] [Abstract][Full Text] [Related]
19. The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells.
Singh R; Winn LM
Mutat Res; 2008 Oct; 645(1-2):33-8. PubMed ID: 18778717
[TBL] [Abstract][Full Text] [Related]
20. Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons.
Deweese JE; Osheroff N
Biochemistry; 2009 Feb; 48(7):1439-41. PubMed ID: 19166355
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
