BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

148 related articles for article (PubMed ID: 17300933)

  • 1. Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthalene benzothiadiazine derivatives.
    Krueger AC; Madigan DL; Green BE; Hutchinson DK; Jiang WW; Kati WM; Liu Y; Maring CJ; Masse SV; McDaniel KF; Middleton TR; Mo H; Molla A; Montgomery DA; Ng TI; Kempf DJ
    Bioorg Med Chem Lett; 2007 Apr; 17(8):2289-92. PubMed ID: 17300933
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.
    Hendricks RT; Fell JB; Blake JF; Fischer JP; Robinson JE; Spencer SR; Stengel PJ; Bernacki AL; Leveque VJ; Le Pogam S; Rajyaguru S; Najera I; Josey JA; Harris JR; Swallow S
    Bioorg Med Chem Lett; 2009 Jul; 19(13):3637-41. PubMed ID: 19447623
    [TBL] [Abstract][Full Text] [Related]  

  • 3. HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives.
    Wang G; Zhang L; Wu X; Das D; Ruhrmund D; Hooi L; Misialek S; Ravi Rajagopalan PT; Buckman BO; Kossen K; Seiwert SD; Beigelman L
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4484-7. PubMed ID: 19497737
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Substituted benzothiadizine inhibitors of Hepatitis C virus polymerase.
    Shaw AN; Tedesco R; Bambal R; Chai D; Concha NO; Darcy MG; Dhanak D; Duffy KJ; Fitch DM; Gates A; Johnston VK; Keenan RM; Lin-Goerke J; Liu N; Sarisky RT; Wiggall KJ; Zimmerman MN
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4350-3. PubMed ID: 19515564
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives.
    Hutchinson DK; Rosenberg T; Klein LL; Bosse TD; Larson DP; He W; Jiang WW; Kati WM; Kohlbrenner WE; Liu Y; Masse SV; Middleton T; Molla A; Montgomery DA; Beno DW; Stewart KD; Stoll VS; Kempf DJ
    Bioorg Med Chem Lett; 2008 Jul; 18(14):3887-90. PubMed ID: 18599294
    [TBL] [Abstract][Full Text] [Related]  

  • 6. HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives.
    Wang G; He Y; Sun J; Das D; Hu M; Huang J; Ruhrmund D; Hooi L; Misialek S; Ravi Rajagopalan PT; Stoycheva A; Buckman BO; Kossen K; Seiwert SD; Beigelman L
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4476-9. PubMed ID: 19502055
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors.
    Das D; Hong J; Chen SH; Wang G; Beigelman L; Seiwert SD; Buckman BO
    Bioorg Med Chem; 2011 Aug; 19(16):4690-703. PubMed ID: 21798747
    [TBL] [Abstract][Full Text] [Related]  

  • 8. HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.
    Wang G; Lei H; Wang X; Das D; Hong J; Mackinnon CH; Coulter TS; Montalbetti CA; Mears R; Gai X; Bailey SE; Ruhrmund D; Hooi L; Misialek S; Rajagopalan PT; Cheng RK; Barker JJ; Felicetti B; Schönfeld DL; Stoycheva A; Buckman BO; Kossen K; Seiwert SD; Beigelman L
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4480-3. PubMed ID: 19500983
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines.
    Pratt JK; Donner P; McDaniel KF; Maring CJ; Kati WM; Mo H; Middleton T; Liu Y; Ng T; Xie Q; Zhang R; Montgomery D; Molla A; Kempf DJ; Kohlbrenner W
    Bioorg Med Chem Lett; 2005 Mar; 15(6):1577-82. PubMed ID: 15745800
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring.
    Rockway TW; Zhang R; Liu D; Betebenner DA; McDaniel KF; Pratt JK; Beno D; Montgomery D; Jiang WW; Masse S; Kati WM; Middleton T; Molla A; Maring CJ; Kempf DJ
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3833-8. PubMed ID: 16650984
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-alkyl-4-hydroxyquinolon-3-yl-benzothiadiazine sulfamides.
    Krueger AC; Madigan DL; Jiang WW; Kati WM; Liu D; Liu Y; Maring CJ; Masse S; McDaniel KF; Middleton T; Mo H; Molla A; Montgomery D; Pratt JK; Rockway TW; Zhang R; Kempf DJ
    Bioorg Med Chem Lett; 2006 Jul; 16(13):3367-70. PubMed ID: 16650764
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.
    Donner PL; Xie Q; Pratt JK; Maring CJ; Kati W; Jiang W; Liu Y; Koev G; Masse S; Montgomery D; Molla A; Kempf DJ
    Bioorg Med Chem Lett; 2008 Apr; 18(8):2735-8. PubMed ID: 18362072
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological characterization of B-ring amino analogues of potent benzothiadiazine hepatitis C virus polymerase inhibitors.
    Randolph JT; Flentge CA; Huang PP; Hutchinson DK; Klein LL; Lim HB; Mondal R; Reisch T; Montgomery DA; Jiang WW; Masse SV; Hernandez LE; Henry RF; Liu Y; Koev G; Kati WM; Stewart KD; Beno DW; Molla A; Kempf DJ
    J Med Chem; 2009 May; 52(10):3174-83. PubMed ID: 19402666
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.
    Hutchinson DK; Flentge CA; Donner PL; Wagner R; Maring CJ; Kati WM; Liu Y; Masse SV; Middleton T; Mo H; Montgomery D; Jiang WW; Koev G; Beno DW; Stewart KD; Stoll VS; Molla A; Kempf DJ
    Bioorg Med Chem Lett; 2011 Mar; 21(6):1876-9. PubMed ID: 21316235
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase.
    Ding Y; Girardet JL; Smith KL; Larson G; Prigaro B; Lai VC; Zhong W; Wu JZ
    Bioorg Med Chem Lett; 2005 Feb; 15(3):675-8. PubMed ID: 15664835
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
    Zhou Y; Webber SE; Murphy DE; Li LS; Dragovich PS; Tran CV; Sun Z; Ruebsam F; Shah AM; Tsan M; Showalter RE; Patel R; Li B; Zhao Q; Han Q; Hermann T; Kissinger CR; Lebrun L; Sergeeva MV; Kirkovsky L
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1413-8. PubMed ID: 18242088
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of anthranilic acid derivatives as a novel class of allosteric inhibitors of hepatitis C NS5B polymerase.
    Nittoli T; Curran K; Insaf S; DiGrandi M; Orlowski M; Chopra R; Agarwal A; Howe AY; Prashad A; Floyd MB; Johnson B; Sutherland A; Wheless K; Feld B; O'Connell J; Mansour TS; Bloom J
    J Med Chem; 2007 May; 50(9):2108-16. PubMed ID: 17402724
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A highly efficient, asymmetric synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
    Fitch DM; Evans KA; Chai D; Duffy KJ
    Org Lett; 2005 Nov; 7(24):5521-4. PubMed ID: 16288546
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.
    McGowan D; Nyanguile O; Cummings MD; Vendeville S; Vandyck K; Van den Broeck W; Boutton CW; De Bondt H; Quirynen L; Amssoms K; Bonfanti JF; Last S; Rombauts K; Tahri A; Hu L; Delouvroy F; Vermeiren K; Vandercruyssen G; Van der Helm L; Cleiren E; Mostmans W; Lory P; Pille G; Van Emelen K; Fanning G; Pauwels F; Lin TI; Simmen K; Raboisson P
    Bioorg Med Chem Lett; 2009 May; 19(9):2492-6. PubMed ID: 19342234
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 3D-QSAR and docking studies on a series of benzothiadiazine derivatives as genotype 1 HCV polymerase inhibitors.
    Patil VM; Gupta SP; Samanta S; Masand N
    Med Chem; 2012 Nov; 8(6):1099-107. PubMed ID: 22779799
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.