BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

132 related articles for article (PubMed ID: 17306550)

  • 1. Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: a combined medicinal chemistry, NMR and computational chemistry approach.
    Goudreau N; Cameron DR; Déziel R; Haché B; Jakalian A; Malenfant E; Naud J; Ogilvie WW; O'meara J; White PW; Yoakim C
    Bioorg Med Chem; 2007 Apr; 15(7):2690-700. PubMed ID: 17306550
    [TBL] [Abstract][Full Text] [Related]  

  • 2. NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
    Hajduk PJ; Dinges J; Miknis GF; Merlock M; Middleton T; Kempf DJ; Egan DA; Walter KA; Robins TS; Shuker SB; Holzman TF; Fesik SW
    J Med Chem; 1997 Sep; 40(20):3144-50. PubMed ID: 9379433
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of the binding site for inhibitors of the HPV11 E1-E2 protein interaction on the E2 transactivation domain by photoaffinity labeling and mass spectrometry.
    Davidson W; McGibbon GA; White PW; Yoakim C; Hopkins JL; Guse I; Hambly DM; Frego L; Ogilvie WW; Lavallée P; Archambault J
    Anal Chem; 2004 Apr; 76(7):2095-102. PubMed ID: 15053675
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of the first series of inhibitors of human papillomavirus type 11: inhibition of the assembly of the E1-E2-Origin DNA complex.
    Yoakim C; Ogilvie WW; Goudreau N; Naud J; Haché B; O'Meara JA; Cordingley MG; Archambault J; White PW
    Bioorg Med Chem Lett; 2003 Aug; 13(15):2539-41. PubMed ID: 12852961
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Small molecule inhibitors of the human papillomavirus E1-E2 interaction.
    White PW; Faucher AM; Goudreau N
    Curr Top Microbiol Immunol; 2011; 348():61-88. PubMed ID: 20676971
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Biphenylsulfonacetic acid inhibitors of the human papillomavirus type 6 E1 helicase inhibit ATP hydrolysis by an allosteric mechanism involving tyrosine 486.
    White PW; Faucher AM; Massariol MJ; Welchner E; Rancourt J; Cartier M; Archambault J
    Antimicrob Agents Chemother; 2005 Dec; 49(12):4834-42. PubMed ID: 16304143
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Discovery of small-molecule inhibitors of the ATPase activity of human papillomavirus E1 helicase.
    Faucher AM; White PW; Brochu C; Grand-Maître C; Rancourt J; Fazal G
    J Med Chem; 2004 Jan; 47(1):18-21. PubMed ID: 14695816
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stereochemistry of pladienolide B.
    Asai N; Kotake Y; Niijima J; Fukuda Y; Uehara T; Sakai T
    J Antibiot (Tokyo); 2007 Jun; 60(6):364-9. PubMed ID: 17617693
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Substituted tetrahydro-beta-carbolines as potential agents for the treatment of human papillomavirus infection.
    Miller JF; Turner EM; Sherrill RG; Gudmundsson K; Spaltenstein A; Sethna P; Brown KW; Harvey R; Romines KR; Golden P
    Bioorg Med Chem Lett; 2010 Jan; 20(1):256-9. PubMed ID: 19914830
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural modifications of salicylates: inhibitors of human CD81-receptor HCV-E2 interaction.
    Holzer M; Ziegler S; Neugebauer A; Kronenberger B; Klein CD; Hartmann RW
    Arch Pharm (Weinheim); 2008 Aug; 341(8):478-84. PubMed ID: 18618487
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, and biological evaluation of potent c-Met inhibitors.
    D'Angelo ND; Bellon SF; Booker SK; Cheng Y; Coxon A; Dominguez C; Fellows I; Hoffman D; Hungate R; Kaplan-Lefko P; Lee MR; Li C; Liu L; Rainbeau E; Reider PJ; Rex K; Siegmund A; Sun Y; Tasker AS; Xi N; Xu S; Yang Y; Zhang Y; Burgess TL; Dussault I; Kim TS
    J Med Chem; 2008 Sep; 51(18):5766-79. PubMed ID: 18763753
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Stereochemistry and conformations of natural 1,2-epoxy-guaianolides based on 1D and 2D NMR data and semiempirical calculations.
    Trifunović S; Milosavljević S; Vajs V; Macura S; Todorović N
    Magn Reson Chem; 2008 May; 46(5):427-31. PubMed ID: 18306444
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity.
    Wang XA; Cianci CW; Yu KL; Combrink KD; Thuring JW; Zhang Y; Civiello RL; Kadow KF; Roach J; Li Z; Langley DR; Krystal M; Meanwell NA
    Bioorg Med Chem Lett; 2007 Aug; 17(16):4592-8. PubMed ID: 17576060
    [TBL] [Abstract][Full Text] [Related]  

  • 14. NMR determination of absolute configuration of butenolides of annonaceous type.
    Latypov S; Franck X; Jullian JC; Hocquemiller R; Figadère B
    Chemistry; 2002 Dec; 8(24):5662-6. PubMed ID: 12693047
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
    Prongay AJ; Guo Z; Yao N; Pichardo J; Fischmann T; Strickland C; Myers J; Weber PC; Beyer BM; Ingram R; Hong Z; Prosise WW; Ramanathan L; Taremi SS; Yarosh-Tomaine T; Zhang R; Senior M; Yang RS; Malcolm B; Arasappan A; Bennett F; Bogen SL; Chen K; Jao E; Liu YT; Lovey RG; Saksena AK; Venkatraman S; Girijavallabhan V; Njoroge FG; Madison V
    J Med Chem; 2007 May; 50(10):2310-8. PubMed ID: 17444623
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Determination of the bound conformation of a competitive nanomolar inhibitor of mycobacterium tuberculosis type II dehydroquinase by NMR spectroscopy.
    Prazeres VF; Sánchez-Sixto C; Castedo L; Canales A; Cañada FJ; Jiménez-Barbero J; Lamb H; Hawkins AR; González-Bello C
    ChemMedChem; 2006 Sep; 1(9):990-6. PubMed ID: 16952136
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of individual structural fragments of N,N'-(bis-5-nitropyrimidyl)dispirotripiperazine derivatives for cytotoxicity and antiherpetic activity allows the prediction of new highly active compounds.
    Artemenko AG; Muratov EN; Kuz'min VE; Kovdienko NA; Hromov AI; Makarov VA; Riabova OB; Wutzler P; Schmidtke M
    J Antimicrob Chemother; 2007 Jul; 60(1):68-77. PubMed ID: 17550890
    [TBL] [Abstract][Full Text] [Related]  

  • 18. N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors.
    Petrocchi A; Jones P; Rowley M; Fiore F; Summa V
    Bioorg Med Chem Lett; 2009 Aug; 19(15):4245-9. PubMed ID: 19523819
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
    Saitoh T; Kuramochi K; Imai T; Takata K; Takehara M; Kobayashi S; Sakaguchi K; Sugawara F
    Bioorg Med Chem; 2008 May; 16(10):5815-25. PubMed ID: 18396405
    [TBL] [Abstract][Full Text] [Related]  

  • 20. New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity.
    Bey E; Marchais-Oberwinkler S; Negri M; Kruchten P; Oster A; Klein T; Spadaro A; Werth R; Frotscher M; Birk B; Hartmann RW
    J Med Chem; 2009 Nov; 52(21):6724-43. PubMed ID: 19831396
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.