142 related articles for article (PubMed ID: 1730674)
1. Site-directed deletion mutants of a carboxyl-terminal region of human dihydrofolate reductase.
Bullerjahn AM; Freisheim JH
J Biol Chem; 1992 Jan; 267(2):864-70. PubMed ID: 1730674
[TBL] [Abstract][Full Text] [Related]
2. The importance of loop region residues 40-46 in human dihydrofolate reductase as revealed by site-directed mutagenesis.
Tan XH; Huang SM; Ratnam M; Thompson PD; Freisheim JH
J Biol Chem; 1990 May; 265(14):8027-32. PubMed ID: 2186034
[TBL] [Abstract][Full Text] [Related]
3. Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim.
Thillet J; Absil J; Stone SR; Pictet R
J Biol Chem; 1988 Sep; 263(25):12500-8. PubMed ID: 3045118
[TBL] [Abstract][Full Text] [Related]
4. Conversion of arginine to lysine at position 70 of human dihydrofolate reductase: generation of a methotrexate-insensitive mutant enzyme.
Thompson PD; Freisheim JH
Biochemistry; 1991 Aug; 30(33):8124-30. PubMed ID: 1907850
[TBL] [Abstract][Full Text] [Related]
5. Role of ionic interactions in ligand binding and catalysis of R67 dihydrofolate reductase.
Hicks SN; Smiley RD; Hamilton JB; Howell EE
Biochemistry; 2003 Sep; 42(36):10569-78. PubMed ID: 12962480
[TBL] [Abstract][Full Text] [Related]
6. Role of the active-site carboxylate in dihydrofolate reductase: kinetic and spectroscopic studies of the aspartate 26-->asparagine mutant of the Lactobacillus casei enzyme.
Basran J; Casarotto MG; Barsukov IL; Roberts GC
Biochemistry; 1995 Mar; 34(9):2872-82. PubMed ID: 7893701
[TBL] [Abstract][Full Text] [Related]
7. Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase.
Huang Z; Wagner CR; Benkovic SJ
Biochemistry; 1994 Sep; 33(38):11576-85. PubMed ID: 7918371
[TBL] [Abstract][Full Text] [Related]
8. Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant.
Cameron CE; Benkovic SJ
Biochemistry; 1997 Dec; 36(50):15792-800. PubMed ID: 9398309
[TBL] [Abstract][Full Text] [Related]
9. Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes.
Cody V; Pace J; Makin J; Piraino J; Queener SF; Rosowsky A
Biochemistry; 2009 Mar; 48(8):1702-11. PubMed ID: 19196009
[TBL] [Abstract][Full Text] [Related]
10. A glutamine 67--> histidine mutation in homotetrameric R67 dihydrofolate reductase results in four mutations per single active site pore and causes substantial substrate and cofactor inhibition.
Park H; Bradrick TD; Howell EE
Protein Eng; 1997 Dec; 10(12):1415-24. PubMed ID: 9543003
[TBL] [Abstract][Full Text] [Related]
11. Engineering specificity for folate into dihydrofolate reductase from Escherichia coli.
Posner BA; Li L; Bethell R; Tsuji T; Benkovic SJ
Biochemistry; 1996 Feb; 35(5):1653-63. PubMed ID: 8634297
[TBL] [Abstract][Full Text] [Related]
12. Role of S65, Q67, I68, and Y69 residues in homotetrameric R67 dihydrofolate reductase.
Strader MB; Smiley RD; Stinnett LG; VerBerkmoes NC; Howell EE
Biochemistry; 2001 Sep; 40(38):11344-52. PubMed ID: 11560482
[TBL] [Abstract][Full Text] [Related]
13. Mapping the antigenic epitopes of human dihydrofolate reductase by systematic synthesis of peptides on solid supports.
Tan XH; Ratnam M; Huang SM; Smith PL; Freisheim JH
J Biol Chem; 1990 May; 265(14):8022-6. PubMed ID: 1692321
[TBL] [Abstract][Full Text] [Related]
14. Solvent environments significantly affect the enzymatic function of Escherichia coli dihydrofolate reductase: comparison of wild-type protein and active-site mutant D27E.
Ohmae E; Miyashita Y; Tate S; Gekko K; Kitazawa S; Kitahara R; Kuwajima K
Biochim Biophys Acta; 2013 Dec; 1834(12):2782-94. PubMed ID: 24140567
[TBL] [Abstract][Full Text] [Related]
15. Deletion of a highly motional residue affects formation of the Michaelis complex for Escherichia coli dihydrofolate reductase.
Miller GP; Benkovic SJ
Biochemistry; 1998 May; 37(18):6327-35. PubMed ID: 9572847
[TBL] [Abstract][Full Text] [Related]
16. In Silico Study Identified Methotrexate Analog as Potential Inhibitor of Drug Resistant Human Dihydrofolate Reductase for Cancer Therapeutics.
Rana RM; Rampogu S; Abid NB; Zeb A; Parate S; Lee G; Yoon S; Kim Y; Kim D; Lee KW
Molecules; 2020 Jul; 25(15):. PubMed ID: 32752079
[TBL] [Abstract][Full Text] [Related]
17. Defining the binding site of homotetrameric R67 dihydrofolate reductase and correlating binding enthalpy with catalysis.
Strader MB; Chopra S; Jackson M; Smiley RD; Stinnett L; Wu J; Howell EE
Biochemistry; 2004 Jun; 43(23):7403-12. PubMed ID: 15182183
[TBL] [Abstract][Full Text] [Related]
18. Contributions of tryptophan 24 and glutamate 30 to binding long-lived water molecules in the ternary complex of human dihydrofolate reductase with methotrexate and NADPH studied by site-directed mutagenesis and nuclear magnetic resonance spectroscopy.
Meiering EM; Li H; Delcamp TJ; Freisheim JH; Wagner G
J Mol Biol; 1995 Mar; 247(2):309-25. PubMed ID: 7707377
[TBL] [Abstract][Full Text] [Related]
19. Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.
Venkitakrishnan RP; Zaborowski E; McElheny D; Benkovic SJ; Dyson HJ; Wright PE
Biochemistry; 2004 Dec; 43(51):16046-55. PubMed ID: 15609999
[TBL] [Abstract][Full Text] [Related]
20. Increased substrate affinity in the Escherichia coli L28R dihydrofolate reductase mutant causes trimethoprim resistance.
Abdizadeh H; Tamer YT; Acar O; Toprak E; Atilgan AR; Atilgan C
Phys Chem Chem Phys; 2017 May; 19(18):11416-11428. PubMed ID: 28422217
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]