BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

195 related articles for article (PubMed ID: 17317569)

  • 1. High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones.
    Tropak MB; Blanchard JE; Withers SG; Brown ED; Mahuran D
    Chem Biol; 2007 Feb; 14(2):153-64. PubMed ID: 17317569
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Pharmacological enhancement of beta-hexosaminidase activity in fibroblasts from adult Tay-Sachs and Sandhoff Patients.
    Tropak MB; Reid SP; Guiral M; Withers SG; Mahuran D
    J Biol Chem; 2004 Apr; 279(14):13478-87. PubMed ID: 14724290
    [TBL] [Abstract][Full Text] [Related]  

  • 3. beta-hexosaminidase in cultured normal and mutant human fibroblasts: an immunohistochemical and biochemical investigation.
    Elsafi ME; Elbashir MI; Hultberg B; Isaksson A; Hägerstrand I; Stenram U
    Scand J Clin Lab Invest; 1991 Dec; 51(8):711-4. PubMed ID: 1839650
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Lending a helping hand, screening chemical libraries for compounds that enhance beta-hexosaminidase A activity in GM2 gangliosidosis cells.
    Tropak MB; Mahuran D
    FEBS J; 2007 Oct; 274(19):4951-61. PubMed ID: 17894780
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease.
    Rountree JS; Butters TD; Wormald MR; Boomkamp SD; Dwek RA; Asano N; Ikeda K; Evinson EL; Nash RJ; Fleet GW
    ChemMedChem; 2009 Mar; 4(3):378-92. PubMed ID: 19145603
    [TBL] [Abstract][Full Text] [Related]  

  • 6. [Beta-N-acetyl-hexosaminidase--the enzyme of Tay-Sachs and Sandhoff diseases].
    Zwierz K; Juszkiewicz J; Arciuch L; Gindzieński A
    Postepy Biochem; 1992; 38(3):127-32. PubMed ID: 1461844
    [No Abstract]   [Full Text] [Related]  

  • 7. Crystal structure of human beta-hexosaminidase B: understanding the molecular basis of Sandhoff and Tay-Sachs disease.
    Mark BL; Mahuran DJ; Cherney MM; Zhao D; Knapp S; James MN
    J Mol Biol; 2003 Apr; 327(5):1093-109. PubMed ID: 12662933
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In situ assessment of beta-hexosaminidase activity.
    Lacorazza HD; Jendoubi M
    Biotechniques; 1995 Sep; 19(3):434-40. PubMed ID: 7495557
    [TBL] [Abstract][Full Text] [Related]  

  • 9. sp
    González-Cuesta M; Herrera-González I; García-Moreno MI; Ashmus RA; Vocadlo DJ; García Fernández JM; Nanba E; Higaki K; Ortiz Mellet C
    J Enzyme Inhib Med Chem; 2022 Dec; 37(1):1364-1374. PubMed ID: 35575117
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis.
    Maegawa GH; Tropak M; Buttner J; Stockley T; Kok F; Clarke JT; Mahuran DJ
    J Biol Chem; 2007 Mar; 282(12):9150-61. PubMed ID: 17237499
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Restoration of hexosaminidase A activity in human Tay-Sachs fibroblasts via adenoviral vector-mediated gene transfer.
    Akli S; Guidotti JE; Vigne E; Perricaudet M; Sandhoff K; Kahn A; Poenaru L
    Gene Ther; 1996 Sep; 3(9):769-74. PubMed ID: 8875224
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tay-Sachs and Sandhoff diseases: enzymatic diagnosis in dried blood spots on filter paper: retrospective diagnoses in newborn-screening cards.
    Chamoles NA; Blanco M; Gaggioli D; Casentini C
    Clin Chim Acta; 2002 Apr; 318(1-2):133-7. PubMed ID: 11880123
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The lysosomal hexosaminidase isozymes.
    Mahuran D; Novak A; Lowden JA
    Isozymes Curr Top Biol Med Res; 1985; 12():229-88. PubMed ID: 3886595
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Epstein-Barr virus transformed lymphoid cell lines as a new model system in culture for the study of GM2-gangliosidoses: Tay-Sachs and Sandhoff diseases.
    Maret A; Salvayre R; Negre A; Bes JC; Douste-Blazy L
    Biol Cell; 1985; 53(3):293-6. PubMed ID: 2990625
    [TBL] [Abstract][Full Text] [Related]  

  • 15. When an inhibitor promotes activity.
    Bouvier M
    Chem Biol; 2007 Mar; 14(3):241-2. PubMed ID: 17379138
    [No Abstract]   [Full Text] [Related]  

  • 16. Enzyme immunoassay of beta-hexosaminidase A and B in serum: carrier detection of GM2-gangliosidoses, and equivalence of enzyme activity and enzyme protein reactivity.
    Isaksson A; Hultberg B; Masson P; Landels E; Fensom A
    Clin Chem; 1993 Jul; 39(7):1412-5. PubMed ID: 8330398
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides.
    Trasler J; Saberi F; Somani IH; Adamali HI; Huang JQ; Fortunato SR; Ritter G; Gu M; Aebersold R; Gravel RA; Hermo L
    Endocrinology; 1998 Jul; 139(7):3280-8. PubMed ID: 9645704
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Isoenzymes of N-acetyl-beta-hexosaminidase.
    Zwierz K; Zalewska A; Zoch-Zwierz A
    Acta Biochim Pol; 1999; 46(3):739-51. PubMed ID: 10698282
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Highly phosphomannosylated enzyme replacement therapy for GM2 gangliosidosis.
    Tsuji D; Akeboshi H; Matsuoka K; Yasuoka H; Miyasaki E; Kasahara Y; Kawashima I; Chiba Y; Jigami Y; Taki T; Sakuraba H; Itoh K
    Ann Neurol; 2011 Apr; 69(4):691-701. PubMed ID: 21520232
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Unusual thermolability properties of beta-hexosaminidase: studies of enzyme from cultured cells and clinical implications.
    Prence EM; Zalewski I; Natowicz MR
    Am J Med Genet; 1996 Nov; 65(4):320-4. PubMed ID: 8923943
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.