BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

318 related articles for article (PubMed ID: 17322884)

  • 1. Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.
    Bowman AB; Lam YC; Jafar-Nejad P; Chen HK; Richman R; Samaco RC; Fryer JD; Kahle JJ; Orr HT; Zoghbi HY
    Nat Genet; 2007 Mar; 39(3):373-9. PubMed ID: 17322884
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.
    Lam YC; Bowman AB; Jafar-Nejad P; Lim J; Richman R; Fryer JD; Hyun ED; Duvick LA; Orr HT; Botas J; Zoghbi HY
    Cell; 2006 Dec; 127(7):1335-47. PubMed ID: 17190598
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.
    Lim J; Crespo-Barreto J; Jafar-Nejad P; Bowman AB; Richman R; Hill DE; Orr HT; Zoghbi HY
    Nature; 2008 Apr; 452(7188):713-8. PubMed ID: 18337722
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Progress in pathogenesis studies of spinocerebellar ataxia type 1.
    Cummings CJ; Orr HT; Zoghbi HY
    Philos Trans R Soc Lond B Biol Sci; 1999 Jun; 354(1386):1079-81. PubMed ID: 10434309
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
    Crespo-Barreto J; Fryer JD; Shaw CA; Orr HT; Zoghbi HY
    PLoS Genet; 2010 Jul; 6(7):e1001021. PubMed ID: 20628574
    [TBL] [Abstract][Full Text] [Related]  

  • 6. SUMO-1 interacts with mutant ataxin-1 and colocalizes to its aggregates in Purkinje cells of SCA1 transgenic mice.
    Kang S; Hong S
    Arch Ital Biol; 2010 Dec; 148(4):351-63. PubMed ID: 21308649
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua.
    Fryer JD; Yu P; Kang H; Mandel-Brehm C; Carter AN; Crespo-Barreto J; Gao Y; Flora A; Shaw C; Orr HT; Zoghbi HY
    Science; 2011 Nov; 334(6056):690-3. PubMed ID: 22053053
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.
    Gehrking KM; Andresen JM; Duvick L; Lough J; Zoghbi HY; Orr HT
    Hum Mol Genet; 2011 Jun; 20(11):2204-12. PubMed ID: 21427130
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Beyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1.
    Ju H; Kokubu H; Lim J
    Mol Neurobiol; 2014 Dec; 50(3):866-874. PubMed ID: 24752589
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model.
    Watase K; Gatchel JR; Sun Y; Emamian E; Atkinson R; Richman R; Mizusawa H; Orr HT; Shaw C; Zoghbi HY
    PLoS Med; 2007 May; 4(5):e182. PubMed ID: 17535104
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.
    Ju H; Kokubu H; Todd TW; Kahle JJ; Kim S; Richman R; Chirala K; Orr HT; Zoghbi HY; Lim J
    J Neurosci; 2013 May; 33(22):9328-36. PubMed ID: 23719801
    [TBL] [Abstract][Full Text] [Related]  

  • 12. SCA1-phosphorylation, a regulator of Ataxin-1 function and pathogenesis.
    Orr HT
    Prog Neurobiol; 2012 Dec; 99(3):179-85. PubMed ID: 22531670
    [TBL] [Abstract][Full Text] [Related]  

  • 13. ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
    Rousseaux MWC; Tschumperlin T; Lu HC; Lackey EP; Bondar VV; Wan YW; Tan Q; Adamski CJ; Friedrich J; Twaroski K; Chen W; Tolar J; Henzler C; Sharma A; Bajić A; Lin T; Duvick L; Liu Z; Sillitoe RV; Zoghbi HY; Orr HT
    Neuron; 2018 Mar; 97(6):1235-1243.e5. PubMed ID: 29526553
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural basis of the phosphorylation dependent complex formation of neurodegenerative disease protein Ataxin-1 and RBM17.
    Kim E; Lee Y; Choi S; Song JJ
    Biochem Biophys Res Commun; 2014 Jul; 449(4):399-404. PubMed ID: 24858692
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Reduction of Purkinje cell pathology in SCA1 transgenic mice by p53 deletion.
    Shahbazian MD; Orr HT; Zoghbi HY
    Neurobiol Dis; 2001 Dec; 8(6):974-81. PubMed ID: 11741393
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.
    Venkatraman A; Hu YS; Didonna A; Cvetanovic M; Krbanjevic A; Bilesimo P; Opal P
    Hum Mol Genet; 2014 Jul; 23(14):3733-45. PubMed ID: 24594842
    [TBL] [Abstract][Full Text] [Related]  

  • 17. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis.
    Lee Y; Samaco RC; Gatchel JR; Thaller C; Orr HT; Zoghbi HY
    Nat Neurosci; 2008 Oct; 11(10):1137-9. PubMed ID: 18758459
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1.
    Sánchez I; Piñol P; Corral-Juan M; Pandolfo M; Matilla-Dueñas A
    Hum Mol Genet; 2013 Sep; 22(17):3425-37. PubMed ID: 23630944
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Spinocerebellar ataxia type 1--modeling the pathogenesis of a polyglutamine neurodegenerative disorder in transgenic mice.
    Clark HB; Orr HT
    J Neuropathol Exp Neurol; 2000 Apr; 59(4):265-70. PubMed ID: 10759181
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and Capicua.
    Kim E; Lu HC; Zoghbi HY; Song JJ
    Genes Dev; 2013 Mar; 27(6):590-5. PubMed ID: 23512657
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.