318 related articles for article (PubMed ID: 17322884)
1. Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes.
Bowman AB; Lam YC; Jafar-Nejad P; Chen HK; Richman R; Samaco RC; Fryer JD; Kahle JJ; Orr HT; Zoghbi HY
Nat Genet; 2007 Mar; 39(3):373-9. PubMed ID: 17322884
[TBL] [Abstract][Full Text] [Related]
2. ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.
Lam YC; Bowman AB; Jafar-Nejad P; Lim J; Richman R; Fryer JD; Hyun ED; Duvick LA; Orr HT; Botas J; Zoghbi HY
Cell; 2006 Dec; 127(7):1335-47. PubMed ID: 17190598
[TBL] [Abstract][Full Text] [Related]
3. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.
Lim J; Crespo-Barreto J; Jafar-Nejad P; Bowman AB; Richman R; Hill DE; Orr HT; Zoghbi HY
Nature; 2008 Apr; 452(7188):713-8. PubMed ID: 18337722
[TBL] [Abstract][Full Text] [Related]
4. Progress in pathogenesis studies of spinocerebellar ataxia type 1.
Cummings CJ; Orr HT; Zoghbi HY
Philos Trans R Soc Lond B Biol Sci; 1999 Jun; 354(1386):1079-81. PubMed ID: 10434309
[TBL] [Abstract][Full Text] [Related]
5. Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
Crespo-Barreto J; Fryer JD; Shaw CA; Orr HT; Zoghbi HY
PLoS Genet; 2010 Jul; 6(7):e1001021. PubMed ID: 20628574
[TBL] [Abstract][Full Text] [Related]
6. SUMO-1 interacts with mutant ataxin-1 and colocalizes to its aggregates in Purkinje cells of SCA1 transgenic mice.
Kang S; Hong S
Arch Ital Biol; 2010 Dec; 148(4):351-63. PubMed ID: 21308649
[TBL] [Abstract][Full Text] [Related]
7. Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua.
Fryer JD; Yu P; Kang H; Mandel-Brehm C; Carter AN; Crespo-Barreto J; Gao Y; Flora A; Shaw C; Orr HT; Zoghbi HY
Science; 2011 Nov; 334(6056):690-3. PubMed ID: 22053053
[TBL] [Abstract][Full Text] [Related]
8. Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model.
Gehrking KM; Andresen JM; Duvick L; Lough J; Zoghbi HY; Orr HT
Hum Mol Genet; 2011 Jun; 20(11):2204-12. PubMed ID: 21427130
[TBL] [Abstract][Full Text] [Related]
9. Beyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1.
Ju H; Kokubu H; Lim J
Mol Neurobiol; 2014 Dec; 50(3):866-874. PubMed ID: 24752589
[TBL] [Abstract][Full Text] [Related]
10. Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model.
Watase K; Gatchel JR; Sun Y; Emamian E; Atkinson R; Richman R; Mizusawa H; Orr HT; Shaw C; Zoghbi HY
PLoS Med; 2007 May; 4(5):e182. PubMed ID: 17535104
[TBL] [Abstract][Full Text] [Related]
11. Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.
Ju H; Kokubu H; Todd TW; Kahle JJ; Kim S; Richman R; Chirala K; Orr HT; Zoghbi HY; Lim J
J Neurosci; 2013 May; 33(22):9328-36. PubMed ID: 23719801
[TBL] [Abstract][Full Text] [Related]
12. SCA1-phosphorylation, a regulator of Ataxin-1 function and pathogenesis.
Orr HT
Prog Neurobiol; 2012 Dec; 99(3):179-85. PubMed ID: 22531670
[TBL] [Abstract][Full Text] [Related]
13. ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
Rousseaux MWC; Tschumperlin T; Lu HC; Lackey EP; Bondar VV; Wan YW; Tan Q; Adamski CJ; Friedrich J; Twaroski K; Chen W; Tolar J; Henzler C; Sharma A; Bajić A; Lin T; Duvick L; Liu Z; Sillitoe RV; Zoghbi HY; Orr HT
Neuron; 2018 Mar; 97(6):1235-1243.e5. PubMed ID: 29526553
[TBL] [Abstract][Full Text] [Related]
14. Structural basis of the phosphorylation dependent complex formation of neurodegenerative disease protein Ataxin-1 and RBM17.
Kim E; Lee Y; Choi S; Song JJ
Biochem Biophys Res Commun; 2014 Jul; 449(4):399-404. PubMed ID: 24858692
[TBL] [Abstract][Full Text] [Related]
15. Reduction of Purkinje cell pathology in SCA1 transgenic mice by p53 deletion.
Shahbazian MD; Orr HT; Zoghbi HY
Neurobiol Dis; 2001 Dec; 8(6):974-81. PubMed ID: 11741393
[TBL] [Abstract][Full Text] [Related]
16. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.
Venkatraman A; Hu YS; Didonna A; Cvetanovic M; Krbanjevic A; Bilesimo P; Opal P
Hum Mol Genet; 2014 Jul; 23(14):3733-45. PubMed ID: 24594842
[TBL] [Abstract][Full Text] [Related]
17. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis.
Lee Y; Samaco RC; Gatchel JR; Thaller C; Orr HT; Zoghbi HY
Nat Neurosci; 2008 Oct; 11(10):1137-9. PubMed ID: 18758459
[TBL] [Abstract][Full Text] [Related]
18. A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1.
Sánchez I; Piñol P; Corral-Juan M; Pandolfo M; Matilla-Dueñas A
Hum Mol Genet; 2013 Sep; 22(17):3425-37. PubMed ID: 23630944
[TBL] [Abstract][Full Text] [Related]
19. Spinocerebellar ataxia type 1--modeling the pathogenesis of a polyglutamine neurodegenerative disorder in transgenic mice.
Clark HB; Orr HT
J Neuropathol Exp Neurol; 2000 Apr; 59(4):265-70. PubMed ID: 10759181
[TBL] [Abstract][Full Text] [Related]
20. Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and Capicua.
Kim E; Lu HC; Zoghbi HY; Song JJ
Genes Dev; 2013 Mar; 27(6):590-5. PubMed ID: 23512657
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]