148 related articles for article (PubMed ID: 17324575)
1. Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity.
Ciliberti N; Manfredini S; Angusti A; Durini E; Solaroli N; Vertuani S; Buzzoni L; Bonache MC; Ben-Shalom E; Karlsson A; Saada A; Balzarini J
Bioorg Med Chem; 2007 Apr; 15(8):3065-81. PubMed ID: 17324575
[TBL] [Abstract][Full Text] [Related]
2. 2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase.
Balzarinia J; Degrève B; Zhu C; Durini E; Porcu L; De Clercq E; Karlsson A; Manfredini S
Biochem Pharmacol; 2001 Mar; 61(6):727-32. PubMed ID: 11266658
[TBL] [Abstract][Full Text] [Related]
3. N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors.
Hernandez AI; Familiar O; Negri A; Rodríguez-Barrios F; Gago F; Karlsson A; Camarasa MJ; Balzarini J; Pérez-Pérez MJ
J Med Chem; 2006 Dec; 49(26):7766-73. PubMed ID: 17181158
[TBL] [Abstract][Full Text] [Related]
4. Activity profiles of deoxynucleoside kinases and 5'-nucleotidases in cultured adipocytes and myoblastic cells: insights into mitochondrial toxicity of nucleoside analogs.
Rylova SN; Albertioni F; Flygh G; Eriksson S
Biochem Pharmacol; 2005 Mar; 69(6):951-60. PubMed ID: 15748706
[TBL] [Abstract][Full Text] [Related]
5. Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity.
Balzarini J; Van Daele I; Negri A; Solaroli N; Karlsson A; Liekens S; Gago F; Van Calenbergh S
Mol Pharmacol; 2009 May; 75(5):1127-36. PubMed ID: 19233899
[TBL] [Abstract][Full Text] [Related]
6. 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase.
Van Poecke S; Negri A; Gago F; Van Daele I; Solaroli N; Karlsson A; Balzarini J; Van Calenbergh S
J Med Chem; 2010 Apr; 53(7):2902-12. PubMed ID: 20218622
[TBL] [Abstract][Full Text] [Related]
7. Probing binding requirements of NAD kinase with modified substrate (NAD) analogues.
Bonnac L; Chen L; Pathak R; Gao G; Ming Q; Bennett E; Felczak K; Kullberg M; Patterson SE; Mazzola F; Magni G; Pankiewicz KW
Bioorg Med Chem Lett; 2007 Mar; 17(6):1512-5. PubMed ID: 17258457
[TBL] [Abstract][Full Text] [Related]
8. Acute cytotoxicity of arabinofuranosyl nucleoside analogs is not dependent on mitochondrial DNA.
Curbo S; Johansson M; Balzarini J; Lewis LD; Karlsson A
Exp Cell Res; 2009 Sep; 315(15):2539-43. PubMed ID: 19481540
[TBL] [Abstract][Full Text] [Related]
9. Retained sensitivity to cytotoxic pyrimidine nucleoside analogs in thymidine kinase 2 deficient human fibroblasts.
Bjerke M; Solaroli N; Lesko N; Balzarini J; Johansson M; Karlsson A
Nucleosides Nucleotides Nucleic Acids; 2010 Jan; 29(1):1-13. PubMed ID: 20391188
[TBL] [Abstract][Full Text] [Related]
10. 5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts.
Wang L; Eriksson S
Nucleosides Nucleotides Nucleic Acids; 2008 Jun; 27(6):858-62. PubMed ID: 18600552
[TBL] [Abstract][Full Text] [Related]
11. Synthesis, modeling and evaluation of 3'-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3'-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors.
Van Poecke S; Negri A; Janssens J; Solaroli N; Karlsson A; Gago F; Balzarini J; Van Calenbergh S
Org Biomol Chem; 2011 Feb; 9(3):892-901. PubMed ID: 21127790
[TBL] [Abstract][Full Text] [Related]
12. The design, synthesis and properties of highly potent and selective inhibitors of herpes simplex virus types 1 and 2 thymidine kinase.
Martin JA; Thomas GJ; Merrett JH; Lambert RW; Bushnell DJ; Dunsdon SJ; Freeman AC; Hopkins RA; Johns IR; Keech E; Simmonite H; Kai-In PW; Holland M
Antivir Chem Chemother; 1998 Jan; 9(1):1-8. PubMed ID: 9875371
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors.
Kuramochi K; Fukudome K; Kuriyama I; Takeuchi T; Sato Y; Kamisuki S; Tsubaki K; Sugawara F; Yoshida H; Mizushina Y
Bioorg Med Chem; 2009 Oct; 17(20):7227-38. PubMed ID: 19767211
[TBL] [Abstract][Full Text] [Related]
14. The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations.
Gazivoda T; Raić-Malić S; Marjanović M; Kralj M; Pavelić K; Balzarini J; De Clercq E; Mintas M
Bioorg Med Chem; 2007 Jan; 15(2):749-58. PubMed ID: 17092728
[TBL] [Abstract][Full Text] [Related]
15. Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications.
Priego EM; Karlsson A; Gago F; Camarasa MJ; Balzarini J; Pérez-Pérez MJ
Curr Pharm Des; 2012; 18(20):2981-94. PubMed ID: 22571666
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.
Manfredini S; Baraldi PG; Durini E; Porcu L; Angusti A; Vertuani S; Solaroli N; De Clercq E; Karlsson A; Balzarini J
Bioorg Med Chem Lett; 2001 May; 11(10):1329-32. PubMed ID: 11392548
[TBL] [Abstract][Full Text] [Related]
17. Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O'-alkyl analogues.
Kierdaszuk B; Krawiec K; Kazimierczuk Z; Jacobsson U; Johansson NG; Munch-Petersen B; Eriksson S; Shugar D
Nucleosides Nucleotides; 1999 Aug; 18(8):1883-903. PubMed ID: 10478487
[TBL] [Abstract][Full Text] [Related]
18. The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture.
Balzarini J; Celen S; Karlsson A; de Groot T; Verbruggen A; Bormans G
Antivir Chem Chemother; 2006; 17(1):17-23. PubMed ID: 16542002
[TBL] [Abstract][Full Text] [Related]
19. Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.
Andrianov V; Gailite V; Lola D; Loza E; Semenikhina V; Kalvinsh I; Finn P; Petersen KD; Ritchie JW; Khan N; Tumber A; Collins LS; Vadlamudi SM; Björkling F; Sehested M
Eur J Med Chem; 2009 Mar; 44(3):1067-85. PubMed ID: 18672316
[TBL] [Abstract][Full Text] [Related]
20. Expression of deoxynucleoside kinases and 5'-nucleotidases in mouse tissues: implications for mitochondrial toxicity.
Rylova SN; Mirzaee S; Albertioni F; Eriksson S
Biochem Pharmacol; 2007 Jun; 74(1):169-75. PubMed ID: 17493587
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
