BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

87 related articles for article (PubMed ID: 17326768)

  • 21. Biogenesis and processing of the amyloid precursor protein in the early secretory pathway.
    Selivanova A; Winblad B; Dantuma NP; Farmery MR
    Biochem Biophys Res Commun; 2007 Jun; 357(4):1034-9. PubMed ID: 17466275
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Inhibition of lysosomal functions reduces proteasomal activity.
    Qiao L; Zhang J
    Neurosci Lett; 2009 May; 456(1):15-9. PubMed ID: 19429125
    [TBL] [Abstract][Full Text] [Related]  

  • 23. The ubiquitin ligase synoviolin up-regulates amyloid β production by targeting a negative regulator of γ-secretase, Rer1, for degradation.
    Tanabe C; Maeda T; Zou K; Liu J; Liu S; Nakajima T; Komano H
    J Biol Chem; 2012 Dec; 287(53):44203-11. PubMed ID: 23129766
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Rac1 changes the substrate specificity of gamma-secretase between amyloid precursor protein and Notch1.
    Boo JH; Sohn JH; Kim JE; Song H; Mook-Jung I
    Biochem Biophys Res Commun; 2008 Aug; 372(4):913-7. PubMed ID: 18538664
    [TBL] [Abstract][Full Text] [Related]  

  • 25. An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor.
    Suzuki Y; Ohta K; Itoh M; Sakoh-Sumitomo Y; Mitsuda T; Ueda M; Hayakawa-Yano Y; Li S; Hida Y; Inuzuka T; Jung YK; Nakagawa T
    FEBS Lett; 2009 May; 583(9):1403-8. PubMed ID: 19376115
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes.
    Shirotani K; Tomioka M; Kremmer E; Haass C; Steiner H
    Neurobiol Dis; 2007 Jul; 27(1):102-7. PubMed ID: 17560791
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Building gamma-secretase: the bits and pieces.
    Spasic D; Annaert W
    J Cell Sci; 2008 Feb; 121(Pt 4):413-20. PubMed ID: 18256384
    [TBL] [Abstract][Full Text] [Related]  

  • 28. N-glycosylation of human nicastrin is required for interaction with the lectins from the secretory pathway calnexin and ERGIC-53.
    Morais VA; Brito C; Pijak DS; Crystal AS; Fortna RR; Li T; Wong PC; Doms RW; Costa J
    Biochim Biophys Acta; 2006 Sep; 1762(9):802-10. PubMed ID: 16938437
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
    Harris B; Pereira I; Parkin E
    Brain Res; 2009 Nov; 1296():203-15. PubMed ID: 19679113
    [TBL] [Abstract][Full Text] [Related]  

  • 30. A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation.
    Tanahashi H; Tabira T
    Neurosci Lett; 2007 Nov; 428(2-3):103-8. PubMed ID: 17961921
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Glu-333 of nicastrin directly participates in gamma-secretase activity.
    Dries DR; Shah S; Han YH; Yu C; Yu S; Shearman MS; Yu G
    J Biol Chem; 2009 Oct; 284(43):29714-24. PubMed ID: 19729449
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
    Kumar VB; Franko M; Banks WA; Kasinadhuni P; Farr SA; Vyas K; Choudhuri V; Morley JE
    J Exp Biol; 2009 Feb; 212(Pt 4):494-8. PubMed ID: 19181896
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
    J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
    [TBL] [Abstract][Full Text] [Related]  

  • 34. p53-dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex.
    Pardossi-Piquard R; Dunys J; Giaime E; Guillot-Sestier MV; St George-Hyslop P; Checler F; Alves da Costa C
    J Neurochem; 2009 Apr; 109(1):225-37. PubMed ID: 19187441
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Shedding-generated Met receptor fragments can be routed to either the proteasomal or the lysosomal degradation pathway.
    Ancot F; Leroy C; Muharram G; Lefebvre J; Vicogne J; Lemiere A; Kherrouche Z; Foveau B; Pourtier A; Melnyk O; Giordano S; Chotteau-Lelievre A; Tulasne D
    Traffic; 2012 Sep; 13(9):1261-72. PubMed ID: 22672335
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of alpha-, beta- and gamma-secretase expression.
    Quiroz-Baez R; Rojas E; Arias C
    Neurochem Int; 2009 Dec; 55(7):662-70. PubMed ID: 19560504
    [TBL] [Abstract][Full Text] [Related]  

  • 37. The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase.
    Sahlin C; Lord A; Magnusson K; Englund H; Almeida CG; Greengard P; Nyberg F; Gouras GK; Lannfelt L; Nilsson LN
    J Neurochem; 2007 May; 101(3):854-62. PubMed ID: 17448150
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.
    Hayashi I; Takatori S; Urano Y; Miyake Y; Takagi J; Sakata-Yanagimoto M; Iwanari H; Osawa S; Morohashi Y; Li T; Wong PC; Chiba S; Kodama T; Hamakubo T; Tomita T; Iwatsubo T
    Oncogene; 2012 Feb; 31(6):787-798. PubMed ID: 21725355
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.
    Sheng B; Gong K; Niu Y; Liu L; Yan Y; Lu G; Zhang L; Hu M; Zhao N; Zhang X; Tang P; Gong Y
    Free Radic Biol Med; 2009 May; 46(10):1362-75. PubMed ID: 19264123
    [TBL] [Abstract][Full Text] [Related]  

  • 40. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S; Price EA; Wu G; Crouthamel MC; Shi XP; Tugusheva K; Tyler KX; Kahana J; Ellis J; Jin L; Steele T; Stachel S; Coburn C; Simon AJ
    J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 5.