126 related articles for article (PubMed ID: 17328531)
1. A quantum mechanics/molecular mechanics study of the catalytic mechanism of the thymidylate synthase.
Kanaan N; Martí S; Moliner V; Kohen A
Biochemistry; 2007 Mar; 46(12):3704-13. PubMed ID: 17328531
[TBL] [Abstract][Full Text] [Related]
2. QM/MM study of thymidylate synthase: enzymatic motions and the temperature dependence of the rate limiting step.
Kanaan N; Martí S; Moliner V; Kohen A
J Phys Chem A; 2009 Mar; 113(10):2176-82. PubMed ID: 19182971
[TBL] [Abstract][Full Text] [Related]
3. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
Spencer HT; Villafranca JE; Appleman JR
Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016
[TBL] [Abstract][Full Text] [Related]
4. Theoretical study of the temperature dependence of dynamic effects in thymidylate synthase.
Kanaan N; Roca M; Tuñón I; Martí S; Moliner V
Phys Chem Chem Phys; 2010 Oct; 12(37):11657-64. PubMed ID: 20714488
[TBL] [Abstract][Full Text] [Related]
5. The influence of active site conformations on the hydride transfer step of the thymidylate synthase reaction mechanism.
Swiderek K; Kohen A; Moliner V
Phys Chem Chem Phys; 2015 Dec; 17(46):30793-804. PubMed ID: 25868526
[TBL] [Abstract][Full Text] [Related]
6. High-level QM/MM calculations support the concerted mechanism for Michael addition and covalent complex formation in thymidylate synthase.
Kaiyawet N; Lonsdale R; Rungrotmongkol T; Mulholland AJ; Hannongbua S
J Chem Theory Comput; 2015 Feb; 11(2):713-22. PubMed ID: 26579604
[TBL] [Abstract][Full Text] [Related]
7. Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools.
Kholodar SA; Ghosh AK; Świderek K; Moliner V; Kohen A
Proc Natl Acad Sci U S A; 2018 Oct; 115(41):10311-10314. PubMed ID: 30249644
[TBL] [Abstract][Full Text] [Related]
8. Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier.
Karunaratne K; Luedtke N; Quinn DM; Kohen A
Arch Biochem Biophys; 2017 Oct; 632():11-19. PubMed ID: 28821425
[TBL] [Abstract][Full Text] [Related]
9. Vibrationally enhanced hydrogen tunneling in the Escherichia coli thymidylate synthase catalyzed reaction.
Agrawal N; Hong B; Mihai C; Kohen A
Biochemistry; 2004 Feb; 43(7):1998-2006. PubMed ID: 14967040
[TBL] [Abstract][Full Text] [Related]
10. Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants.
Variath P; Liu Y; Lee TT; Stroud RM; Santi DV
Biochemistry; 2000 Mar; 39(10):2429-35. PubMed ID: 10704192
[TBL] [Abstract][Full Text] [Related]
11. Temperature dependence of the kinetic isotope effects in thymidylate synthase. A theoretical study.
Kanaan N; Ferrer S; Martí S; Garcia-Viloca M; Kohen A; Moliner V
J Am Chem Soc; 2011 May; 133(17):6692-702. PubMed ID: 21476498
[TBL] [Abstract][Full Text] [Related]
12. Examinations of the Chemical Step in Enzyme Catalysis.
Singh P; Islam Z; Kohen A
Methods Enzymol; 2016; 577():287-318. PubMed ID: 27498642
[TBL] [Abstract][Full Text] [Related]
13. Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access.
Fritz TA; Liu L; Finer-Moore JS; Stroud RM
Biochemistry; 2002 Jun; 41(22):7021-9. PubMed ID: 12033935
[TBL] [Abstract][Full Text] [Related]
14. Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate.
Hyatt DC; Maley F; Montfort WR
Biochemistry; 1997 Apr; 36(15):4585-94. PubMed ID: 9109668
[TBL] [Abstract][Full Text] [Related]
15. Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis.
Doan LT; Martucci WE; Vargo MA; Atreya CE; Anderson KS
Biochemistry; 2007 Jul; 46(28):8379-91. PubMed ID: 17580969
[TBL] [Abstract][Full Text] [Related]
16. Microscale synthesis of isotopically labeled R-[6-xH]N5,N10-methylene-5,6,7,8-tetrahydrofolate as a cofactor for thymidylate synthase.
Agrawal N; Mihai C; Kohen A
Anal Biochem; 2004 May; 328(1):44-50. PubMed ID: 15081906
[TBL] [Abstract][Full Text] [Related]
17. An alternative flavin-dependent mechanism for thymidylate synthesis.
Myllykallio H; Lipowski G; Leduc D; Filee J; Forterre P; Liebl U
Science; 2002 Jul; 297(5578):105-7. PubMed ID: 12029065
[TBL] [Abstract][Full Text] [Related]
18. QM/MM calculations suggest a novel intermediate following the proton abstraction catalyzed by thymidylate synthase.
Wang Z; Ferrer S; Moliner V; Kohen A
Biochemistry; 2013 Apr; 52(13):2348-58. PubMed ID: 23464672
[TBL] [Abstract][Full Text] [Related]
19. Concerted versus stepwise mechanism in thymidylate synthase.
Islam Z; Strutzenberg TS; Gurevic I; Kohen A
J Am Chem Soc; 2014 Jul; 136(28):9850-3. PubMed ID: 24949852
[TBL] [Abstract][Full Text] [Related]
20. A Single Mutation Traps a Half-Sites Reactive Enzyme in Midstream, Explaining Asymmetry in Hydride Transfer.
Finer-Moore JS; Lee TT; Stroud RM
Biochemistry; 2018 May; 57(19):2786-2795. PubMed ID: 29717875
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]