162 related articles for article (PubMed ID: 17329803)
1. A high-resolution structure of ligand-free human glutamate carboxypeptidase II.
Barinka C; Starkova J; Konvalinka J; Lubkowski J
Acta Crystallogr Sect F Struct Biol Cryst Commun; 2007 Mar; 63(Pt 3):150-3. PubMed ID: 17329803
[TBL] [Abstract][Full Text] [Related]
2. Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.
Barinka C; Hlouchova K; Rovenska M; Majer P; Dauter M; Hin N; Ko YS; Tsukamoto T; Slusher BS; Konvalinka J; Lubkowski J
J Mol Biol; 2008 Mar; 376(5):1438-50. PubMed ID: 18234225
[TBL] [Abstract][Full Text] [Related]
3. Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity.
Barinka C; Sácha P; Sklenár J; Man P; Bezouska K; Slusher BS; Konvalinka J
Protein Sci; 2004 Jun; 13(6):1627-35. PubMed ID: 15152093
[TBL] [Abstract][Full Text] [Related]
4. Amino acids at the N- and C-termini of human glutamate carboxypeptidase II are required for enzymatic activity and proper folding.
Barinka C; Mlcochová P; Sácha P; Hilgert I; Majer P; Slusher BS; Horejsí V; Konvalinka J
Eur J Biochem; 2004 Jul; 271(13):2782-90. PubMed ID: 15206943
[TBL] [Abstract][Full Text] [Related]
5. Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.
Hlouchova K; Barinka C; Konvalinka J; Lubkowski J
FEBS J; 2009 Aug; 276(16):4448-62. PubMed ID: 19678840
[TBL] [Abstract][Full Text] [Related]
6. Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis.
Mlcochová P; Plechanovová A; Barinka C; Mahadevan D; Saldanha JW; Rulísek L; Konvalinka J
FEBS J; 2007 Sep; 274(18):4731-41. PubMed ID: 17714508
[TBL] [Abstract][Full Text] [Related]
7. Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.
Mesters JR; Barinka C; Li W; Tsukamoto T; Majer P; Slusher BS; Konvalinka J; Hilgenfeld R
EMBO J; 2006 Mar; 25(6):1375-84. PubMed ID: 16467855
[TBL] [Abstract][Full Text] [Related]
8. Structural and biochemical characterization of the folyl-poly-γ-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II.
Navrátil M; Ptáček J; Šácha P; Starková J; Lubkowski J; Bařinka C; Konvalinka J
FEBS J; 2014 Jul; 281(14):3228-42. PubMed ID: 24863754
[TBL] [Abstract][Full Text] [Related]
9. Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.
Barinka C; Rovenská M; Mlcochová P; Hlouchová K; Plechanovová A; Majer P; Tsukamoto T; Slusher BS; Konvalinka J; Lubkowski J
J Med Chem; 2007 Jul; 50(14):3267-73. PubMed ID: 17567119
[TBL] [Abstract][Full Text] [Related]
10. Structure-activity relationships of glutamate carboxypeptidase II (GCPII) inhibitors.
Ferraris DV; Shukla K; Tsukamoto T
Curr Med Chem; 2012; 19(9):1282-94. PubMed ID: 22304717
[TBL] [Abstract][Full Text] [Related]
11. Comparison of human glutamate carboxypeptidases II and III reveals their divergent substrate specificities.
Navrátil M; Tykvart J; Schimer J; Pachl P; Navrátil V; Rokob TA; Hlouchová K; Rulíšek L; Konvalinka J
FEBS J; 2016 Jul; 283(13):2528-45. PubMed ID: 27208881
[TBL] [Abstract][Full Text] [Related]
12. Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II.
Pavlicek J; Ptacek J; Cerny J; Byun Y; Skultetyova L; Pomper MG; Lubkowski J; Barinka C
Bioorg Med Chem Lett; 2014 May; 24(10):2340-5. PubMed ID: 24731280
[TBL] [Abstract][Full Text] [Related]
13. Efficient and versatile one-step affinity purification of in vivo biotinylated proteins: expression, characterization and structure analysis of recombinant human glutamate carboxypeptidase II.
Tykvart J; Sácha P; Bařinka C; Knedlík T; Starková J; Lubkowski J; Konvalinka J
Protein Expr Purif; 2012 Mar; 82(1):106-15. PubMed ID: 22178733
[TBL] [Abstract][Full Text] [Related]
14. Glutamate carboxypeptidase II: an overview of structural studies and their importance for structure-based drug design and deciphering the reaction mechanism of the enzyme.
Pavlícek J; Ptácek J; Barinka C
Curr Med Chem; 2012; 19(9):1300-9. PubMed ID: 22304708
[TBL] [Abstract][Full Text] [Related]
15. Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.
Tykvart J; Schimer J; Bařinková J; Pachl P; Poštová-Slavětínská L; Majer P; Konvalinka J; Šácha P
Bioorg Med Chem; 2014 Aug; 22(15):4099-108. PubMed ID: 24954515
[TBL] [Abstract][Full Text] [Related]
16. Expression of glutamate carboxypeptidase II in human brain.
Sácha P; Zámecník J; Barinka C; Hlouchová K; Vícha A; Mlcochová P; Hilgert I; Eckschlager T; Konvalinka J
Neuroscience; 2007 Feb; 144(4):1361-72. PubMed ID: 17150306
[TBL] [Abstract][Full Text] [Related]
17. Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods.
Klusák V; Barinka C; Plechanovová A; Mlcochová P; Konvalinka J; Rulísek L; Lubkowski J
Biochemistry; 2009 May; 48(19):4126-38. PubMed ID: 19301871
[TBL] [Abstract][Full Text] [Related]
18. Glutamate carboxypeptidase II does not process amyloid-β peptide.
Sedlák F; Šácha P; Blechová M; Březinová A; Šafařík M; Šebestík J; Konvalinka J
FASEB J; 2013 Jul; 27(7):2626-32. PubMed ID: 23525279
[TBL] [Abstract][Full Text] [Related]
19. Evaluation of 68Ga-Glutamate Carboxypeptidase II Ligand Positron Emission Tomography for Clinical Molecular Imaging of Atherosclerotic Plaque Neovascularization.
Derlin T; Thiele J; Weiberg D; Thackeray JT; Püschel K; Wester HJ; Aguirre Dávila L; Larena-Avellaneda A; Daum G; Bengel FM; Schumacher U
Arterioscler Thromb Vasc Biol; 2016 Nov; 36(11):2213-2219. PubMed ID: 27609368
[TBL] [Abstract][Full Text] [Related]
20. Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II.
Tykvart J; Schimer J; Jančařík A; Bařinková J; Navrátil V; Starková J; Šrámková K; Konvalinka J; Majer P; Šácha P
J Med Chem; 2015 May; 58(10):4357-63. PubMed ID: 25923815
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
