BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

751 related articles for article (PubMed ID: 17333344)

  • 61. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
    Senkovich O; Schormann N; Chattopadhyay D
    Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691
    [TBL] [Abstract][Full Text] [Related]  

  • 62. New antifolates in clinical development.
    Takimoto CH; Allegra CJ
    Oncology (Williston Park); 1995 Jul; 9(7):649-56, 659 DISC 660, 662, 665. PubMed ID: 8924375
    [TBL] [Abstract][Full Text] [Related]  

  • 63. The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
    Chattopadhyay S; Zhao R; Krupenko SA; Krupenko N; Goldman ID
    Mol Cancer Ther; 2006 Feb; 5(2):438-49. PubMed ID: 16505119
    [TBL] [Abstract][Full Text] [Related]  

  • 64. Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia.
    Stark M; Wichman C; Avivi I; Assaraf YG
    Blood; 2009 Apr; 113(18):4362-9. PubMed ID: 19131550
    [TBL] [Abstract][Full Text] [Related]  

  • 65. Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
    Seither RL; Trent DF; Mikulecky DC; Rape TJ; Goldman ID
    J Biol Chem; 1989 Oct; 264(29):17016-23. PubMed ID: 2529254
    [TBL] [Abstract][Full Text] [Related]  

  • 66. Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.
    Backus HH; Pinedo HM; Wouters D; Padrón JM; Molders N; van Der Wilt CL; van Groeningen CJ; Jansen G; Peters GJ
    Int J Cancer; 2000 Sep; 87(6):771-8. PubMed ID: 10956384
    [TBL] [Abstract][Full Text] [Related]  

  • 67. Characterization and comparative studies of zebrafish and human recombinant dihydrofolate reductases--inhibition by folic acid and polyphenols.
    Kao TT; Wang KC; Chang WN; Lin CY; Chen BH; Wu HL; Shi GY; Tsai JN; Fu TF
    Drug Metab Dispos; 2008 Mar; 36(3):508-16. PubMed ID: 18056255
    [TBL] [Abstract][Full Text] [Related]  

  • 68. Multidrug resistance proteins and folate supplementation: therapeutic implications for antifolates and other classes of drugs in cancer treatment.
    Hooijberg JH; de Vries NA; Kaspers GJ; Pieters R; Jansen G; Peters GJ
    Cancer Chemother Pharmacol; 2006 Jul; 58(1):1-12. PubMed ID: 16362298
    [TBL] [Abstract][Full Text] [Related]  

  • 69. [Methotrexate resistance in acute leukemias].
    Styczyński J; Wysocki M
    Pol Merkur Lekarski; 2001 Aug; 11(62):175-9. PubMed ID: 11757224
    [TBL] [Abstract][Full Text] [Related]  

  • 70. Mechanisms of resistance of malaria parasites to antifolates.
    Gregson A; Plowe CV
    Pharmacol Rev; 2005 Mar; 57(1):117-45. PubMed ID: 15734729
    [TBL] [Abstract][Full Text] [Related]  

  • 71. Variable expression of RFC1 in human leukemia cell lines resistant to antifolates.
    Kobayashi H; Takemura Y; Ohnuma T
    Cancer Lett; 1998 Feb; 124(2):135-42. PubMed ID: 9500202
    [TBL] [Abstract][Full Text] [Related]  

  • 72. The molecular identity and characterization of a Proton-coupled Folate Transporter--PCFT; biological ramifications and impact on the activity of pemetrexed.
    Zhao R; Goldman ID
    Cancer Metastasis Rev; 2007 Mar; 26(1):129-39. PubMed ID: 17340171
    [TBL] [Abstract][Full Text] [Related]  

  • 73. Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance.
    Shapira A; Livney YD; Broxterman HJ; Assaraf YG
    Drug Resist Updat; 2011 Jun; 14(3):150-63. PubMed ID: 21330184
    [TBL] [Abstract][Full Text] [Related]  

  • 74. Transfection studies to explore essential folate metabolism and antifolate drug synergy in the human malaria parasite Plasmodium falciparum.
    Wang P; Wang Q; Aspinall TV; Sims PF; Hyde JE
    Mol Microbiol; 2004 Mar; 51(5):1425-38. PubMed ID: 14982635
    [TBL] [Abstract][Full Text] [Related]  

  • 75. New perspectives on folate transport in relation to alcoholism-induced folate malabsorption--association with epigenome stability and cancer development.
    Hamid A; Wani NA; Kaur J
    FEBS J; 2009 Apr; 276(8):2175-91. PubMed ID: 19292860
    [TBL] [Abstract][Full Text] [Related]  

  • 76. Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs.
    McGuire JJ; Haile WH
    Biochem Pharmacol; 2009 Apr; 77(7):1161-72. PubMed ID: 19174154
    [TBL] [Abstract][Full Text] [Related]  

  • 77. [Clinical pharmacology of anticancer agents [Part 5] Antimetabolites (2)].
    Nakamura T; Ueda T; Uchida M
    Gan To Kagaku Ryoho; 1992 Mar; 19(3):409-20. PubMed ID: 1543370
    [TBL] [Abstract][Full Text] [Related]  

  • 78. An overview of folate metabolism: features relevant to the action and toxicities of antifolate anticancer agents.
    Calvert H
    Semin Oncol; 1999 Apr; 26(2 Suppl 6):3-10. PubMed ID: 10598549
    [No Abstract]   [Full Text] [Related]  

  • 79. Folylpoly-gamma-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity.
    Qi H; Atkinson I; Xiao S; Choi YJ; Tobimatsu T; Shane B
    Adv Enzyme Regul; 1999; 39():263-73. PubMed ID: 10470377
    [TBL] [Abstract][Full Text] [Related]  

  • 80. Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients.
    Odin E; Wettergren Y; Nilsson S; Willén R; Carlsson G; Spears CP; Larsson L; Gustavsson B
    Clin Cancer Res; 2003 Dec; 9(16 Pt 1):6012-9. PubMed ID: 14676127
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 38.