These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

236 related articles for article (PubMed ID: 17339891)

  • 1. Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.
    Giovannetti E; Backus HH; Wouters D; Ferreira CG; van Houten VM; Brakenhoff RH; Poupon MF; Azzarello A; Pinedo HM; Peters GJ
    Br J Cancer; 2007 Mar; 96(5):769-75. PubMed ID: 17339891
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells.
    Giovannetti E; Backus HH; Wouters D; Peters GJ
    Nucleosides Nucleotides Nucleic Acids; 2008 Jun; 27(6):740-5. PubMed ID: 18600534
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.
    Backus HH; Wouters D; Ferreira CG; van Houten VM; Brakenhoff RH; Pinedo HM; Peters GJ
    Eur J Cancer; 2003 Jun; 39(9):1310-7. PubMed ID: 12763222
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor raltitrexed.
    Peters GJ; van Triest B; Backus HH; Kuiper CM; van der Wilt CL; Pinedo HM
    Eur J Cancer; 2000 May; 36(7):916-24. PubMed ID: 10785598
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chronic exposure of colorectal cancer cells in culture to fluoropyrimidine analogs induces thymidylate synthase and suppresses p53. A molecular explanation for the mechanism of 5-FU resistance.
    Subbarayan PR; Sarkar M; Nelson G; Benitez E; Singhal S; Ardalan B
    Anticancer Res; 2010 Apr; 30(4):1149-56. PubMed ID: 20530421
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates.
    Backus HH; Pinedo HM; Wouters D; Kuiper CM; Jansen G; van Groeningen CJ; Peters GJ
    Oncol Res; 2000; 12(5):231-9. PubMed ID: 11417748
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.
    Wang W; McLeod HL; Cassidy J; Collie-Duguid ES
    Cancer Chemother Pharmacol; 2007 May; 59(6):839-45. PubMed ID: 17119966
    [TBL] [Abstract][Full Text] [Related]  

  • 8. [Effects of RNA interference and nolatrexed on thymidylate synthase expression and cell proliferation of human colorectal carcinoma LOVO cells].
    Tian SB; Jing CQ; Li LP
    Zhonghua Wei Chang Wai Ke Za Zhi; 2012 Nov; 15(11):1187-91. PubMed ID: 23172536
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.
    Sigmond J; Backus HH; Wouters D; Temmink OH; Jansen G; Peters GJ
    Biochem Pharmacol; 2003 Aug; 66(3):431-8. PubMed ID: 12907242
    [TBL] [Abstract][Full Text] [Related]  

  • 10. p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival.
    Lenz HJ; Hayashi K; Salonga D; Danenberg KD; Danenberg PV; Metzger R; Banerjee D; Bertino JR; Groshen S; Leichman LP; Leichman CG
    Clin Cancer Res; 1998 May; 4(5):1243-50. PubMed ID: 9607583
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
    Peters GJ; Smitskamp-Wilms E; Smid K; Pinedo HM; Jansen G
    Cancer Res; 1999 Nov; 59(21):5529-35. PubMed ID: 10554030
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma.
    Wong NA; Brett L; Stewart M; Leitch A; Longley DB; Dunlop MG; Johnston PG; Lessells AM; Jodrell DI
    Br J Cancer; 2001 Dec; 85(12):1937-43. PubMed ID: 11747337
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Apoptosis and thymidylate synthase inductions by 5-fluorouracil in gastric cancer cells with or without p53 mutation.
    Yukimoto K; Nakata B; Muguruma K; Yashiro M; Ohira M; Ishikawa T; Hino M; Hirakawa K
    Int J Oncol; 2001 Aug; 19(2):373-8. PubMed ID: 11445854
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The interaction of thymidylate synthase expression with p53-regulated signaling pathways in tumor cells.
    Longley DB; Latif T; Boyer J; Allen WL; Maxwell PJ; Johnston PG
    Semin Oncol; 2003 Jun; 30(3 Suppl 6):3-9. PubMed ID: 12802789
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inter-relationship between microsatellite instability, thymidylate synthase expression, and p53 status in colorectal cancer: implications for chemoresistance.
    Popat S; Wort R; Houlston RS
    BMC Cancer; 2006 Jun; 6():150. PubMed ID: 16753067
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Polymorphisms in the enhancer region of the thymidylate synthase gene are associated with thymidylate synthase levels in normal tissues but not in malignant tissues of patients with colorectal cancer.
    Mauritz R; Giovannetti E; Beumer IJ; Smid K; Van Groeningen CJ; Pinedo HM; Peters GJ
    Clin Colorectal Cancer; 2009 Jul; 8(3):146-54. PubMed ID: 19632929
    [TBL] [Abstract][Full Text] [Related]  

  • 17. [Effects of nolatrexed on thymidylate synthase protein expression].
    Li YL; Wu SG
    Di Yi Jun Yi Da Xue Xue Bao; 2004 Aug; 24(8):881-4. PubMed ID: 15321751
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.
    Peters GJ; Backus HH; Freemantle S; van Triest B; Codacci-Pisanelli G; van der Wilt CL; Smid K; Lunec J; Calvert AH; Marsh S; McLeod HL; Bloemena E; Meijer S; Jansen G; van Groeningen CJ; Pinedo HM
    Biochim Biophys Acta; 2002 Jul; 1587(2-3):194-205. PubMed ID: 12084461
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates.
    Longley DB; Boyer J; Allen WL; Latif T; Ferguson PR; Maxwell PJ; McDermott U; Lynch M; Harkin DP; Johnston PG
    Cancer Res; 2002 May; 62(9):2644-9. PubMed ID: 11980662
    [TBL] [Abstract][Full Text] [Related]  

  • 20. TS mRNA levels can predict pemetrexed and raltitrexed sensitivity in colorectal cancer.
    Zhang Q; Shen J; Wang H; Hu J; Yu L; Xie L; Wei J; Liu B; Guan W; Qian X
    Cancer Chemother Pharmacol; 2014 Feb; 73(2):325-33. PubMed ID: 24281197
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.