BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

248 related articles for article (PubMed ID: 17341133)

  • 1. Arkadia enhances Nodal/TGF-beta signaling by coupling phospho-Smad2/3 activity and turnover.
    Mavrakis KJ; Andrew RL; Lee KL; Petropoulou C; Dixon JE; Navaratnam N; Norris DP; Episkopou V
    PLoS Biol; 2007 Mar; 5(3):e67. PubMed ID: 17341133
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts.
    Yuzawa H; Koinuma D; Maeda S; Yamamoto K; Miyazawa K; Imamura T
    Bone; 2009 Jan; 44(1):53-60. PubMed ID: 18950738
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Enhancement of TGF-β signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer.
    Sharma V; Antonacopoulou AG; Tanaka S; Panoutsopoulos AA; Bravou V; Kalofonos HP; Episkopou V
    Cancer Res; 2011 Oct; 71(20):6438-49. PubMed ID: 21998011
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
    Levy L; Howell M; Das D; Harkin S; Episkopou V; Hill CS
    Mol Cell Biol; 2007 Sep; 27(17):6068-83. PubMed ID: 17591695
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells.
    Guzman-Ayala M; Lee KL; Mavrakis KJ; Goggolidou P; Norris DP; Episkopou V
    PLoS One; 2009; 4(1):e4268. PubMed ID: 19172185
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia.
    Xia T; Lévy L; Levillayer F; Jia B; Li G; Neuveut C; Buendia MA; Lan K; Wei Y
    J Biol Chem; 2013 Jan; 288(3):1785-94. PubMed ID: 23212909
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.
    Liu W; Rui H; Wang J; Lin S; He Y; Chen M; Li Q; Ye Z; Zhang S; Chan SC; Chen YG; Han J; Lin SC
    EMBO J; 2006 Apr; 25(8):1646-58. PubMed ID: 16601693
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.
    Gao S; Alarcón C; Sapkota G; Rahman S; Chen PY; Goerner N; Macias MJ; Erdjument-Bromage H; Tempst P; Massagué J
    Mol Cell; 2009 Nov; 36(3):457-68. PubMed ID: 19917253
    [TBL] [Abstract][Full Text] [Related]  

  • 9. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos.
    Redshaw N; Camps C; Sharma V; Motallebipour M; Guzman-Ayala M; Oikonomopoulos S; Thymiakou E; Ragoussis J; Episkopou V
    PLoS One; 2013; 8(1):e55186. PubMed ID: 23390484
    [TBL] [Abstract][Full Text] [Related]  

  • 10. RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.
    Koinuma D; Shinozaki M; Nagano Y; Ikushima H; Horiguchi K; Goto K; Chano T; Saitoh M; Imamura T; Miyazono K; Miyazawa K
    J Biol Chem; 2011 Sep; 286(37):32502-12. PubMed ID: 21795712
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.
    Nakano A; Koinuma D; Miyazawa K; Uchida T; Saitoh M; Kawabata M; Hanai J; Akiyama H; Abe M; Miyazono K; Matsumoto T; Imamura T
    J Biol Chem; 2009 Mar; 284(10):6109-15. PubMed ID: 19122240
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational Plasticity.
    Birkou M; Chasapis CT; Marousis KD; Loutsidou AK; Bentrop D; Lelli M; Herrmann T; Carthy JM; Episkopou V; Spyroulias GA
    J Mol Biol; 2017 Jul; 429(15):2373-2386. PubMed ID: 28647409
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling.
    Lin X; Liang M; Feng XH
    J Biol Chem; 2000 Nov; 275(47):36818-22. PubMed ID: 11016919
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling.
    Aragón E; Wang Q; Zou Y; Morgani SM; Ruiz L; Kaczmarska Z; Su J; Torner C; Tian L; Hu J; Shu W; Agrawal S; Gomes T; Márquez JA; Hadjantonakis AK; Macias MJ; Massagué J
    Genes Dev; 2019 Nov; 33(21-22):1506-1524. PubMed ID: 31582430
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis.
    Liu FY; Li XZ; Peng YM; Liu H; Liu YH
    Am J Nephrol; 2007; 27(2):176-83. PubMed ID: 17347560
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.
    Briones-Orta MA; Levy L; Madsen CD; Das D; Erker Y; Sahai E; Hill CS
    Cancer Res; 2013 Mar; 73(6):1800-10. PubMed ID: 23467611
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7.
    Koinuma D; Shinozaki M; Komuro A; Goto K; Saitoh M; Hanyu A; Ebina M; Nukiwa T; Miyazawa K; Imamura T; Miyazono K
    EMBO J; 2003 Dec; 22(24):6458-70. PubMed ID: 14657019
    [TBL] [Abstract][Full Text] [Related]  

  • 18. TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.
    Bonni S; Wang HR; Causing CG; Kavsak P; Stroschein SL; Luo K; Wrana JL
    Nat Cell Biol; 2001 Jun; 3(6):587-95. PubMed ID: 11389444
    [TBL] [Abstract][Full Text] [Related]  

  • 19. RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3.
    Antonson P; Jakobsson T; Almlöf T; Guldevall K; Steffensen KR; Gustafsson JA
    J Biol Chem; 2008 Apr; 283(14):8995-9001. PubMed ID: 18263591
    [TBL] [Abstract][Full Text] [Related]  

  • 20. smad2 and smad3 are required for mesendoderm induction by transforming growth factor-beta/nodal signals in zebrafish.
    Jia S; Ren Z; Li X; Zheng Y; Meng A
    J Biol Chem; 2008 Jan; 283(4):2418-26. PubMed ID: 18025082
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.