BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

401 related articles for article (PubMed ID: 17347064)

  • 1. Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in ovariectomized mice.
    Xiang A; Kanematsu M; Kumar S; Yamashita D; Kaise T; Kikkawa H; Asano S; Kinoshita M
    Bone; 2007 May; 40(5):1231-7. PubMed ID: 17347064
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys.
    Kumar S; Dare L; Vasko-Moser JA; James IE; Blake SM; Rickard DJ; Hwang SM; Tomaszek T; Yamashita DS; Marquis RW; Oh H; Jeong JU; Veber DF; Gowen M; Lark MW; Stroup G
    Bone; 2007 Jan; 40(1):122-31. PubMed ID: 16962401
    [TBL] [Abstract][Full Text] [Related]  

  • 3. An orally active cathepsin K inhibitor, furan-2-carboxylic acid, 1-{1-[4-fluoro-2-(2-oxo-pyrrolidin-1-yl)-phenyl]-3-oxo-piperidin-4-ylcarbamoyl}-cyclohexyl)-amide (OST-4077), inhibits osteoclast activity in vitro and bone loss in ovariectomized rats.
    Kim MK; Kim HD; Park JH; Lim JI; Yang JS; Kwak WY; Sung SY; Kim HJ; Kim SH; Lee CH; Shim JY; Bae MH; Shin YA; Huh Y; Han TD; Chong W; Choi H; Ahn BN; Yang SO; Son MH
    J Pharmacol Exp Ther; 2006 Aug; 318(2):555-62. PubMed ID: 16699068
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The anabolic action of intermittent PTH in combination with cathepsin K inhibitor or alendronate differs depending on the remodeling status in bone in ovariectomized mice.
    Yamane H; Sakai A; Mori T; Tanaka S; Moridera K; Nakamura T
    Bone; 2009 Jun; 44(6):1055-62. PubMed ID: 19303837
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A potent small molecule, nonpeptide inhibitor of cathepsin K (SB 331750) prevents bone matrix resorption in the ovariectomized rat.
    Lark MW; Stroup GB; James IE; Dodds RA; Hwang SM; Blake SM; Lechowska BA; Hoffman SJ; Smith BR; Kapadia R; Liang X; Erhard K; Ru Y; Dong X; Marquis RW; Veber D; Gowen M
    Bone; 2002 May; 30(5):746-53. PubMed ID: 11996914
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts.
    Kneissel M; Luong-Nguyen NH; Baptist M; Cortesi R; Zumstein-Mecker S; Kossida S; O'Reilly T; Lane H; Susa M
    Bone; 2004 Nov; 35(5):1144-56. PubMed ID: 15542040
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a nonhuman primate.
    Stroup GB; Lark MW; Veber DF; Bhattacharyya A; Blake S; Dare LC; Erhard KF; Hoffman SJ; James IE; Marquis RW; Ru Y; Vasko-Moser JA; Smith BR; Tomaszek T; Gowen M
    J Bone Miner Res; 2001 Oct; 16(10):1739-46. PubMed ID: 11585335
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Treatment with a potent cathepsin K inhibitor preserves cortical and trabecular bone mass in ovariectomized monkeys.
    Stroup GB; Kumar S; Jerome CP
    Calcif Tissue Int; 2009 Oct; 85(4):344-55. PubMed ID: 19763376
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Analysis of change patterns of microcomputed tomography 3-dimensional bone parameters as a high-throughput tool to evaluate antiosteoporotic effects of agents at an early stage of ovariectomy-induced osteoporosis in mice.
    Xiang A; Kanematsu M; Mitamura M; Kikkawa H; Asano S; Kinoshita M
    Invest Radiol; 2006 Sep; 41(9):704-12. PubMed ID: 16896306
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Bone density, strength, and formation in adult cathepsin K (-/-) mice.
    Pennypacker B; Shea M; Liu Q; Masarachia P; Saftig P; Rodan S; Rodan G; Kimmel D
    Bone; 2009 Feb; 44(2):199-207. PubMed ID: 18845279
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Dose effects of propranolol on cancellous and cortical bone in ovariectomized adult rats.
    Bonnet N; Laroche N; Vico L; Dolleans E; Benhamou CL; Courteix D
    J Pharmacol Exp Ther; 2006 Sep; 318(3):1118-27. PubMed ID: 16740619
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effect of vitamin K2 on three-dimensional trabecular microarchitecture in ovariectomized rats.
    Mawatari T; Miura H; Higaki H; Moro-Oka T; Kurata K; Murakami T; Iwamoto Y
    J Bone Miner Res; 2000 Sep; 15(9):1810-7. PubMed ID: 10977000
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Long-term minodronic acid (ONO-5920/YM529) treatment suppresses increased bone turnover, plus prevents reduction in bone mass and bone strength in ovariectomized rats with established osteopenia.
    Tanaka M; Mori H; Kayasuga R; Ochi Y; Kawada N; Yamada H; Kishikawa K
    Bone; 2008 Nov; 43(5):894-900. PubMed ID: 18687415
    [TBL] [Abstract][Full Text] [Related]  

  • 14. An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice.
    Panwar P; Xue L; Søe K; Srivastava K; Law S; Delaisse JM; Brömme D
    J Bone Miner Res; 2017 Dec; 32(12):2415-2430. PubMed ID: 28745432
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo.
    Hughes A; Rogers MJ; Idris AI; Crockett JC
    Calcif Tissue Int; 2007 Nov; 81(5):403-13. PubMed ID: 17982704
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Hydrolyzed collagen improves bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo study.
    Guillerminet F; Beaupied H; Fabien-Soulé V; Tomé D; Benhamou CL; Roux C; Blais A
    Bone; 2010 Mar; 46(3):827-34. PubMed ID: 19895915
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Prevention of trabecular bone loss induced by estrogen deficiency by a selective p38alpha inhibitor.
    Caverzasio J; Higgins L; Ammann P
    J Bone Miner Res; 2008 Sep; 23(9):1389-97. PubMed ID: 18442314
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Rolipram, a phosphodiesterase 4 inhibitor, prevented cancellous and cortical bone loss by inhibiting endosteal bone resorption and maintaining the elevated periosteal bone formation in adult ovariectomized rats.
    Yao W; Tian XY; Chen J; Setterberg RB; Lundy MW; Chmielzwski P; Froman CA; Jee WS
    J Musculoskelet Neuronal Interact; 2007; 7(2):119-30. PubMed ID: 17627081
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones.
    Xia L; Kilb J; Wex H; Li Z; Lipyansky A; Breuil V; Stein L; Palmer JT; Dempster DW; Brömme D
    Biol Chem; 1999 Jun; 380(6):679-87. PubMed ID: 10430032
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Radiation effects on bone architecture in mice and rats resulting from in vivo micro-computed tomography scanning.
    Klinck RJ; Campbell GM; Boyd SK
    Med Eng Phys; 2008 Sep; 30(7):888-95. PubMed ID: 18249025
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 21.