145 related articles for article (PubMed ID: 17348638)
1. Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.
Dolman NP; More JC; Alt A; Knauss JL; Pentikäinen OT; Glasser CR; Bleakman D; Mayer ML; Collingridge GL; Jane DE
J Med Chem; 2007 Apr; 50(7):1558-70. PubMed ID: 17348638
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.
Dolman NP; Troop HM; More JC; Alt A; Knauss JL; Nistico R; Jack S; Morley RM; Bortolotto ZA; Roberts PJ; Bleakman D; Collingridge GL; Jane DE
J Med Chem; 2005 Dec; 48(24):7867-81. PubMed ID: 16302825
[TBL] [Abstract][Full Text] [Related]
3. Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.
Dolman NP; More JC; Alt A; Knauss JL; Troop HM; Bleakman D; Collingridge GL; Jane DE
J Med Chem; 2006 Apr; 49(8):2579-92. PubMed ID: 16610801
[TBL] [Abstract][Full Text] [Related]
4. Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists.
More JC; Troop HM; Dolman NP; Jane DE
Br J Pharmacol; 2003 Mar; 138(6):1093-100. PubMed ID: 12684265
[TBL] [Abstract][Full Text] [Related]
5. Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.
More JC; Nistico R; Dolman NP; Clarke VR; Alt AJ; Ogden AM; Buelens FP; Troop HM; Kelland EE; Pilato F; Bleakman D; Bortolotto ZA; Collingridge GL; Jane DE
Neuropharmacology; 2004 Jul; 47(1):46-64. PubMed ID: 15165833
[TBL] [Abstract][Full Text] [Related]
6. The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres.
More JC; Troop HM; Jane DE
Br J Pharmacol; 2002 Dec; 137(7):1125-33. PubMed ID: 12429586
[TBL] [Abstract][Full Text] [Related]
7. Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
Jane DE; Hoo K; Kamboj R; Deverill M; Bleakman D; Mandelzys A
J Med Chem; 1997 Oct; 40(22):3645-50. PubMed ID: 9357531
[TBL] [Abstract][Full Text] [Related]
8. Pharmacological differentiation of kainate receptors on neonatal rat spinal motoneurones and dorsal roots.
Thomas NK; Hawkins LM; Miller JC; Troop HM; Roberts PJ; Jane DE
Neuropharmacology; 1998; 37(10-11):1223-37. PubMed ID: 9849660
[TBL] [Abstract][Full Text] [Related]
9. ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.
Dargan SL; Clarke VR; Alushin GM; Sherwood JL; Nisticò R; Bortolotto ZA; Ogden AM; Bleakman D; Doherty AJ; Lodge D; Mayer ML; Fitzjohn SM; Jane DE; Collingridge GL
Neuropharmacology; 2009 Jan; 56(1):121-30. PubMed ID: 18789344
[TBL] [Abstract][Full Text] [Related]
10. Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.
Wong LA; Mayer ML; Jane DE; Watkins JC
J Neurosci; 1994 Jun; 14(6):3881-97. PubMed ID: 7515954
[TBL] [Abstract][Full Text] [Related]
11. 3-hydroxypyridazine 1-oxides as carboxylate bioisosteres: a new series of subtype-selective AMPA receptor agonists.
Greenwood JR; Mewett KN; Allan RD; Martín BO; Pickering DS
Neuropharmacology; 2006 Jul; 51(1):52-9. PubMed ID: 16631211
[TBL] [Abstract][Full Text] [Related]
12. Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
Patneau DK; Mayer ML; Jane DE; Watkins JC
J Neurosci; 1992 Feb; 12(2):595-606. PubMed ID: 1371315
[TBL] [Abstract][Full Text] [Related]
13. N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships, and in Vitro Pharmacology.
Pallesen J; Møllerud S; Frydenvang K; Pickering DS; Bornholdt J; Nielsen B; Pasini D; Han L; Marconi L; Kastrup JS; Johansen TN
ACS Chem Neurosci; 2019 Mar; 10(3):1841-1853. PubMed ID: 30620174
[TBL] [Abstract][Full Text] [Related]
14. 3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands.
Szymańska E; Pickering DS; Nielsen B; Johansen TN
Bioorg Med Chem; 2009 Sep; 17(17):6390-401. PubMed ID: 19656686
[TBL] [Abstract][Full Text] [Related]
15. Antagonism of recombinant and native GluK3-containing kainate receptors.
Perrais D; Pinheiro PS; Jane DE; Mulle C
Neuropharmacology; 2009 Jan; 56(1):131-40. PubMed ID: 18761361
[TBL] [Abstract][Full Text] [Related]
16. Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization.
Venskutonyte R; Butini S; Coccone SS; Gemma S; Brindisi M; Kumar V; Guarino E; Maramai S; Valenti S; Amir A; Valadés EA; Frydenvang K; Kastrup JS; Novellino E; Campiani G; Pickering DS
J Med Chem; 2011 Jul; 54(13):4793-805. PubMed ID: 21619066
[TBL] [Abstract][Full Text] [Related]
17. Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.
Ahmed AH; Thompson MD; Fenwick MK; Romero B; Loh AP; Jane DE; Sondermann H; Oswald RE
Biochemistry; 2009 May; 48(18):3894-903. PubMed ID: 19284741
[TBL] [Abstract][Full Text] [Related]
18. Calcium inhibits willardiine-induced responses in kainate receptor GluR6(Q)/KA-2.
Fukushima T; Marshall J; Sakata K; Shingai R
Neuroreport; 2001 Jan; 12(1):163-7. PubMed ID: 11201079
[TBL] [Abstract][Full Text] [Related]
19. Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties.
Campiani G; Morelli E; Nacci V; Fattorusso C; Ramunno A; Novellino E; Greenwood J; Liljefors T; Griffiths R; Sinclair C; Reavy H; Kristensen AS; Pickering DS; Schousboe A; Cagnotto A; Fumagalli E; Mennini T
J Med Chem; 2001 Dec; 44(26):4501-4. PubMed ID: 11741469
[TBL] [Abstract][Full Text] [Related]
20. NMR spectroscopy of the ligand-binding core of ionotropic glutamate receptor 2 bound to 5-substituted willardiine partial agonists.
Fenwick MK; Oswald RE
J Mol Biol; 2008 May; 378(3):673-85. PubMed ID: 18387631
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
