BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

386 related articles for article (PubMed ID: 17350040)

  • 1. Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.
    Race PR; Lovering AL; White SA; Grove JI; Searle PF; Wrighton CW; Hyde EI
    J Mol Biol; 2007 Apr; 368(2):481-92. PubMed ID: 17350040
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Steady-state and stopped-flow kinetic studies of three Escherichia coli NfsB mutants with enhanced activity for the prodrug CB1954.
    Jarrom D; Jaberipour M; Guise CP; Daff S; White SA; Searle PF; Hyde EI
    Biochemistry; 2009 Aug; 48(32):7665-72. PubMed ID: 19580253
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: effects of combining beneficial single mutations.
    Jaberipour M; Vass SO; Guise CP; Grove JI; Knox RJ; Hu L; Hyde EI; Searle PF
    Biochem Pharmacol; 2010 Jan; 79(2):102-11. PubMed ID: 19665450
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism of CB1954 reduction by Escherichia coli nitroreductase.
    Christofferson A; Wilkie J
    Biochem Soc Trans; 2009 Apr; 37(Pt 2):413-8. PubMed ID: 19290872
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.
    Grove JI; Lovering AL; Guise C; Race PR; Wrighton CJ; White SA; Hyde EI; Searle PF
    Cancer Res; 2003 Sep; 63(17):5532-7. PubMed ID: 14500391
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form.
    Johansson E; Parkinson GN; Denny WA; Neidle S
    J Med Chem; 2003 Sep; 46(19):4009-20. PubMed ID: 12954054
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution.
    Lovering AL; Hyde EI; Searle PF; White SA
    J Mol Biol; 2001 May; 309(1):203-13. PubMed ID: 11491290
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954.
    Prosser GA; Copp JN; Syddall SP; Williams EM; Smaill JB; Wilson WR; Patterson AV; Ackerley DF
    Biochem Pharmacol; 2010 Mar; 79(5):678-87. PubMed ID: 19852945
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.
    Searle PF; Chen MJ; Hu L; Race PR; Lovering AL; Grove JI; Guise C; Jaberipour M; James ND; Mautner V; Young LS; Kerr DJ; Mountain A; White SA; Hyde EI
    Clin Exp Pharmacol Physiol; 2004 Nov; 31(11):811-6. PubMed ID: 15566399
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle.
    Guise CP; Grove JI; Hyde EI; Searle PF
    Gene Ther; 2007 Apr; 14(8):690-8. PubMed ID: 17301844
    [TBL] [Abstract][Full Text] [Related]  

  • 11. E. coli nitroreductase/CB1954 gene-directed enzyme prodrug therapy: role of arylamine N-acetlytransferase 2.
    Mitchell DJ; Minchin RF
    Cancer Gene Ther; 2008 Nov; 15(11):758-64. PubMed ID: 18600257
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Nitroreductase from Bacillus licheniformis: a stable enzyme for prodrug activation.
    Emptage CD; Knox RJ; Danson MJ; Hough DW
    Biochem Pharmacol; 2009 Jan; 77(1):21-9. PubMed ID: 18840409
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.
    Helsby NA; Atwell GJ; Yang S; Palmer BD; Anderson RF; Pullen SM; Ferry DM; Hogg A; Wilson WR; Denny WA
    J Med Chem; 2004 Jun; 47(12):3295-307. PubMed ID: 15163209
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector.
    Chen MJ; Green NK; Reynolds GM; Flavell JR; Mautner V; Kerr DJ; Young LS; Searle PF
    Gene Ther; 2004 Jul; 11(14):1126-36. PubMed ID: 15164095
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Virus-directed enzyme prodrug therapy using CB1954.
    Grove JI; Searle PF; Weedon SJ; Green NK; McNeish IA; Kerr DJ
    Anticancer Drug Des; 1999 Dec; 14(6):461-72. PubMed ID: 10834268
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Identification of novel nitroreductases from Bacillus cereus and their interaction with the CB1954 prodrug.
    Gwenin VV; Poornima P; Halliwell J; Ball P; Robinson G; Gwenin CD
    Biochem Pharmacol; 2015 Dec; 98(3):392-402. PubMed ID: 26415543
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.
    McNeish IA; Green NK; Gilligan MG; Ford MJ; Mautner V; Young LS; Kerr DJ; Searle PF
    Gene Ther; 1998 Aug; 5(8):1061-9. PubMed ID: 10326029
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--I. Purification and properties of a nitroreductase enzyme from Escherichia coli--a potential enzyme for antibody-directed enzyme prodrug therapy (ADEPT).
    Anlezark GM; Melton RG; Sherwood RF; Coles B; Friedlos F; Knox RJ
    Biochem Pharmacol; 1992 Dec; 44(12):2289-95. PubMed ID: 1472094
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Investigation of alternative prodrugs for use with E. coli nitroreductase in 'suicide gene' approaches to cancer therapy.
    Bailey SM; Knox RJ; Hobbs SM; Jenkins TC; Mauger AB; Melton RG; Burke PJ; Connors TA; Hart IR
    Gene Ther; 1996 Dec; 3(12):1143-50. PubMed ID: 8986441
    [TBL] [Abstract][Full Text] [Related]  

  • 20. uvrB gene deletion enhances SOS chromotest sensitivity for nitroreductases that preferentially generate the 4-hydroxylamine metabolite of the anti-cancer prodrug CB1954.
    Prosser GA; Patterson AV; Ackerley DF
    J Biotechnol; 2010 Oct; 150(1):190-4. PubMed ID: 20727918
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.