66 related articles for article (PubMed ID: 17376561)
1. γ₂-Melanocyte stimulation hormone (γ₂-MSH) truncation studies results in the cautionary note that γ₂-MSH is not selective for the mouse MC3R over the mouse MC5R.
Joseph CG; Yao H; Scott JW; Sorensen NB; Marnane RN; Mountjoy KG; Haskell-Luevano C
Peptides; 2010 Dec; 31(12):2304-13. PubMed ID: 20833220
[TBL] [Abstract][Full Text] [Related]
2. Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH
Mowlazadeh Haghighi S; Zhou Y; Dai J; Sawyer JR; Hruby VJ; Cai M
Eur J Med Chem; 2018 May; 151():815-823. PubMed ID: 29679901
[TBL] [Abstract][Full Text] [Related]
3. Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mice.
Fleming KA; Ericson MD; Freeman KT; Adank DN; Lunzer MM; Wilber SL; Haskell-Luevano C
ACS Chem Neurosci; 2018 May; 9(5):1141-1151. PubMed ID: 29363944
[TBL] [Abstract][Full Text] [Related]
4. An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells.
Cai M; Stankova M; Muthu D; Mayorov A; Yang Z; Trivedi D; Cabello C; Hruby VJ
Biochemistry; 2013 Jan; 52(4):752-64. PubMed ID: 23276279
[TBL] [Abstract][Full Text] [Related]
5. Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors.
Mayorov AV; Cai M; Palmer ES; Liu Z; Cain JP; Vagner J; Trivedi D; Hruby VJ
Peptides; 2010 Oct; 31(10):1894-905. PubMed ID: 20688117
[TBL] [Abstract][Full Text] [Related]
6. Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)].
Ericson MD; Freeman KT; Larson CM; Bouchard JL; John K; Lunzer MM; Koerperich ZM; Haskell-Luevano C
ACS Pharmacol Transl Sci; 2024 Apr; 7(4):1114-1125. PubMed ID: 38633589
[TBL] [Abstract][Full Text] [Related]
7. Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge.
Hruby VJ; Cai M; Cain J; Nyberg J; Trivedi D
Eur J Pharmacol; 2011 Jun; 660(1):88-93. PubMed ID: 21208601
[TBL] [Abstract][Full Text] [Related]
8. Melanocortin antagonist tetrapeptides with minimal agonist activity at the mouse melanocortin-3 receptor.
Doering SR; Todorovic A; Haskell-Luevano C
ACS Med Chem Lett; 2015 Feb; 6(2):123-7. PubMed ID: 25699138
[TBL] [Abstract][Full Text] [Related]
9. Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist.
Ericson MD; Doering SR; Larson CM; Freeman KT; LaVoi TM; Donow HM; Santos RG; Cho RH; Koerperich ZM; Giulianotti MA; Pinilla C; Houghten RA; Haskell-Luevano C
J Med Chem; 2021 Oct; 64(19):14860-14875. PubMed ID: 34592820
[TBL] [Abstract][Full Text] [Related]
10. Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a μM MC4R Partial Agonist.
Fleming KA; Freeman KT; Powers MD; Santos RG; Debevec G; Giulianotti MA; Houghten RA; Doering SR; Pinilla C; Haskell-Luevano C
J Med Chem; 2019 Mar; 62(5):2738-2749. PubMed ID: 30741545
[TBL] [Abstract][Full Text] [Related]
11. Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.
Ericson MD; Lensing CJ; Fleming KA; Schlasner KN; Doering SR; Haskell-Luevano C
Biochim Biophys Acta Mol Basis Dis; 2017 Oct; 1863(10 Pt A):2414-2435. PubMed ID: 28363699
[TBL] [Abstract][Full Text] [Related]
12. Two complex genotypes relevant to the kynurenine pathway and melanotropin function show association with schizophrenia and bipolar disorder.
Miller CL; Murakami P; Ruczinski I; Ross RG; Sinkus M; Sullivan B; Leonard S
Schizophr Res; 2009 Sep; 113(2-3):259-67. PubMed ID: 19502010
[TBL] [Abstract][Full Text] [Related]
13. Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor.
Mayorov AV; Cai M; Palmer ES; Dedek MM; Cain JP; Van Scoy AR; Tan B; Vagner J; Trivedi D; Hruby VJ
J Med Chem; 2008 Jan; 51(2):187-95. PubMed ID: 18088090
[TBL] [Abstract][Full Text] [Related]
14. Potent and selective agonists of alpha-melanotropin (alphaMSH) action at human melanocortin receptor 5; linear analogs of alpha-melanotropin.
Bednarek MA; MacNeil T; Tang R; Fong TM; Cabello MA; Maroto M; Teran A
Peptides; 2007 May; 28(5):1020-8. PubMed ID: 17376561
[TBL] [Abstract][Full Text] [Related]
15. Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors.
Haskell-Luevano C; Nikiforovich G; Sharma SD; Yang YK; Dickinson C; Hruby VJ; Gantz I
J Med Chem; 1997 May; 40(11):1738-48. PubMed ID: 9171884
[TBL] [Abstract][Full Text] [Related]
16. Potent and selective agonists of human melanocortin receptor 5: cyclic analogues of alpha-melanocyte-stimulating hormone.
Bednarek MA; MacNeil T; Tang R; Fong TM; Cabello MA; Maroto M; Teran A
J Med Chem; 2007 May; 50(10):2520-6. PubMed ID: 17455928
[TBL] [Abstract][Full Text] [Related]
17. Analogs of alpha-melanocyte stimulating hormone with high agonist potency and selectivity at human melanocortin receptor 1b: the role of Trp(9) in molecular recognition.
Bednarek MA; Macneil T; Tang R; Fong TM; Angeles Cabello M; Maroto M; Teran A
Biopolymers; 2008 May; 89(5):401-8. PubMed ID: 17926329
[TBL] [Abstract][Full Text] [Related]
18. Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors.
Cai M; Mayorov AV; Ying J; Stankova M; Trivedi D; Cabello C; Hruby VJ
Peptides; 2005 Aug; 26(8):1481-5. PubMed ID: 15876475
[TBL] [Abstract][Full Text] [Related]
19.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
20.
; ; . PubMed ID:
[No Abstract] [Full Text] [Related]
[Next] [New Search]
