357 related articles for article (PubMed ID: 17403914)
1. Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes.
Kang P; Dalvie D; Smith E; Zhou S; Deese A
Drug Metab Dispos; 2007 Jul; 35(7):1081-8. PubMed ID: 17403914
[TBL] [Abstract][Full Text] [Related]
2. Bioactivation of flutamide metabolites by human liver microsomes.
Kang P; Dalvie D; Smith E; Zhou S; Deese A; Nieman JA
Drug Metab Dispos; 2008 Jul; 36(7):1425-37. PubMed ID: 18411402
[TBL] [Abstract][Full Text] [Related]
3. Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase.
Wen B; Coe KJ; Rademacher P; Fitch WL; Monshouwer M; Nelson SD
Chem Res Toxicol; 2008 Dec; 21(12):2393-406. PubMed ID: 19548358
[TBL] [Abstract][Full Text] [Related]
4. Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice.
Matsuzaki Y; Nagai D; Ichimura E; Goda R; Tomura A; Doi M; Nishikawa K
J Gastroenterol; 2006 Mar; 41(3):231-9. PubMed ID: 16699857
[TBL] [Abstract][Full Text] [Related]
5. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
Wen B; Ma L; Zhu M
Chem Biol Interact; 2008 May; 173(1):59-67. PubMed ID: 18359012
[TBL] [Abstract][Full Text] [Related]
6. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
[TBL] [Abstract][Full Text] [Related]
7. Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.
Wen B; Chen Y; Fitch WL
Drug Metab Dispos; 2009 Jul; 37(7):1557-62. PubMed ID: 19364830
[TBL] [Abstract][Full Text] [Related]
8. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite.
Kazui M; Nishiya Y; Ishizuka T; Hagihara K; Farid NA; Okazaki O; Ikeda T; Kurihara A
Drug Metab Dispos; 2010 Jan; 38(1):92-9. PubMed ID: 19812348
[TBL] [Abstract][Full Text] [Related]
9. In vitro metabolic activation of thiabendazole via 5-hydroxythiabendazole: identification of a glutathione conjugate of 5-hydroxythiabendazole.
Dalvie D; Smith E; Deese A; Bowlin S
Drug Metab Dispos; 2006 Apr; 34(4):709-17. PubMed ID: 16434547
[TBL] [Abstract][Full Text] [Related]
10. Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.
Murayama N; Imai N; Nakane T; Shimizu M; Yamazaki H
Biochem Pharmacol; 2007 Jun; 73(12):2020-6. PubMed ID: 17433262
[TBL] [Abstract][Full Text] [Related]
11. Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.
Jeurissen SM; Bogaards JJ; Boersma MG; ter Horst JP; Awad HM; Fiamegos YC; van Beek TA; Alink GM; Sudhölter EJ; Cnubben NH; Rietjens IM
Chem Res Toxicol; 2006 Jan; 19(1):111-6. PubMed ID: 16411663
[TBL] [Abstract][Full Text] [Related]
12. Dehydrogenation of indoline by cytochrome P450 enzymes: a novel "aromatase" process.
Sun H; Ehlhardt WJ; Kulanthaivel P; Lanza DL; Reilly CA; Yost GS
J Pharmacol Exp Ther; 2007 Aug; 322(2):843-51. PubMed ID: 17502430
[TBL] [Abstract][Full Text] [Related]
13. In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite.
Mahajan MK; Uttamsingh V; Daniels JS; Gan LS; LeDuc BW; Williams DA
Drug Metab Dispos; 2011 Apr; 39(4):693-702. PubMed ID: 21177487
[TBL] [Abstract][Full Text] [Related]
14. Metabolic activation of the indoloquinazoline alkaloids evodiamine and rutaecarpine by human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.
Wen B; Roongta V; Liu L; Moore DJ
Drug Metab Dispos; 2014 Jun; 42(6):1044-54. PubMed ID: 24696463
[TBL] [Abstract][Full Text] [Related]
15. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
Boerma JS; Vermeulen NP; Commandeur JN
Chem Biol Interact; 2014 Jan; 207():32-40. PubMed ID: 24246759
[TBL] [Abstract][Full Text] [Related]
16. In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.
Tachibana S; Fujimaki Y; Yokoyama H; Okazaki O; Sudo K
Drug Metab Dispos; 2005 Nov; 33(11):1628-36. PubMed ID: 16049129
[TBL] [Abstract][Full Text] [Related]
17. Characterization of the NADPH-dependent metabolism of 17beta-estradiol to multiple metabolites by human liver microsomes and selectively expressed human cytochrome P450 3A4 and 3A5.
Lee AJ; Kosh JW; Conney AH; Zhu BT
J Pharmacol Exp Ther; 2001 Aug; 298(2):420-32. PubMed ID: 11454902
[TBL] [Abstract][Full Text] [Related]
18. Flutamide metabolism in four different species in vitro and identification of flutamide metabolites in human patient urine by high performance liquid chromatography/tandem mass spectrometry.
Tevell A; Lennernäs H; Jönsson M; Norlin M; Lennernäs B; Bondesson U; Hedeland M
Drug Metab Dispos; 2006 Jun; 34(6):984-92. PubMed ID: 16540588
[TBL] [Abstract][Full Text] [Related]
19. Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.
Lim HK; Duczak N; Brougham L; Elliot M; Patel K; Chan K
Drug Metab Dispos; 2005 Aug; 33(8):1211-9. PubMed ID: 15860655
[TBL] [Abstract][Full Text] [Related]
20. A semiquantitative method for the determination of reactive metabolite conjugate levels in vitro utilizing liquid chromatography-tandem mass spectrometry and novel quaternary ammonium glutathione analogues.
Soglia JR; Contillo LG; Kalgutkar AS; Zhao S; Hop CE; Boyd JG; Cole MJ
Chem Res Toxicol; 2006 Mar; 19(3):480-90. PubMed ID: 16544956
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
