BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1941 related articles for article (PubMed ID: 17403915)

  • 1. Biotransformation of 6-methoxy-3-(3',4',5'-trimethoxy-benzoyl)-1H-indole (BPR0L075), a novel antimicrotubule agent, by mouse, rat, dog, and human liver microsomes.
    Yao HT; Wu YS; Chang YW; Hsieh HP; Chen WC; Lan SJ; Chen CT; Chao YS; Chang L; Sun HY; Yeh TK
    Drug Metab Dispos; 2007 Jul; 35(7):1042-9. PubMed ID: 17403915
    [TBL] [Abstract][Full Text] [Related]  

  • 2. In vitro metabolism study of combretastatin A-4 in rat and human liver microsomes.
    Aprile S; Del Grosso E; Tron GC; Grosa G
    Drug Metab Dispos; 2007 Dec; 35(12):2252-61. PubMed ID: 17890446
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.
    Yamazaki H; Guo Z; Persmark M; Mimura M; Inoue K; Guengerich FP; Shimada T
    Mol Pharmacol; 1994 Sep; 46(3):568-77. PubMed ID: 7935340
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A.
    Niwa T; Shiraga T; Mitani Y; Terakawa M; Tokuma Y; Kagayama A
    Drug Metab Dispos; 2000 Sep; 28(9):1128-34. PubMed ID: 10950860
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites.
    Remmel RP; Crews BC; Kozak KR; Kalgutkar AS; Marnett LJ
    Drug Metab Dispos; 2004 Jan; 32(1):113-22. PubMed ID: 14709628
    [TBL] [Abstract][Full Text] [Related]  

  • 6. CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver.
    Dehal SS; Kupfer D
    Cancer Res; 1997 Aug; 57(16):3402-6. PubMed ID: 9270005
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS; Hatch HL; Kosea F; Nguyen HT; Choo EF; McClure KF; Taylor TJ; Henne KR; Kuperman AV; Dombroski MA; Letavic MA
    Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Influence of N-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivity.
    Venhorst J; Onderwater RC; Meerman JH; Commandeur JN; Vermeulen NP
    Drug Metab Dispos; 2000 Dec; 28(12):1524-32. PubMed ID: 11095593
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Metabolism of sanguinarine in human and in rat: characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography-tandem mass spectrometry.
    Deroussent A; RĂ© M; Hoellinger H; Cresteil T
    J Pharm Biomed Anal; 2010 Jul; 52(3):391-7. PubMed ID: 19804952
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Biotransformation of a novel antimitotic agent, I-387, by mouse, rat, dog, monkey, and human liver microsomes and in vivo pharmacokinetics in mice.
    Ahn S; Kearbey JD; Li CM; Duke CB; Miller DD; Dalton JT
    Drug Metab Dispos; 2011 Apr; 39(4):636-43. PubMed ID: 21233217
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Metabolism of the new anxiolytic agent, a pyrido[1,2-]benzimidazole (PBI) analog (RWJ-53050), in rat and human hepatic S9 fractions, and in dog; identification of cytochrome p450 isoforms mediated in the human microsomal metabolism.
    Wu WN; McKown LA; Reitz AB
    Eur J Drug Metab Pharmacokinet; 2006; 31(4):277-83. PubMed ID: 17315539
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Species differences in the toxicity and cytochrome P450 IIIA-dependent metabolism of digitoxin.
    Eberhart DC; Gemzik B; Halvorson MR; Parkinson A
    Mol Pharmacol; 1991 Nov; 40(5):859-67. PubMed ID: 1944247
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Metabolism of dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) by human liver microsomes: characterization of metabolic pathways and of cytochrome P450 isoforms involved.
    Baek MS; Kim JY; Myung SW; Yim YH; Jeong JH; Kim DH
    Drug Metab Dispos; 2001 Apr; 29(4 Pt 1):381-8. PubMed ID: 11259320
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2.
    Raza H; King RS; Squires RB; Guengerich FP; Miller DW; Freeman JP; Lang NP; Kadlubar FF
    Drug Metab Dispos; 1996 Apr; 24(4):395-400. PubMed ID: 8801053
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
    Tang W; Stearns RA; Wang RW; Chiu SH; Baillie TA
    Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation.
    Kim KH; Isin EM; Yun CH; Kim DH; Guengerich FP
    FEBS J; 2006 May; 273(10):2223-31. PubMed ID: 16649998
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of diuron N-demethylation by mammalian hepatic microsomes and cDNA-expressed human cytochrome P450 enzymes.
    Abass K; Reponen P; Turpeinen M; Jalonen J; Pelkonen O
    Drug Metab Dispos; 2007 Sep; 35(9):1634-41. PubMed ID: 17576805
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The In vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes.
    Zhao XJ; Ishizaki T
    J Pharmacol Exp Ther; 1997 Dec; 283(3):1168-76. PubMed ID: 9399990
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells.
    Reilly CA; Ehlhardt WJ; Jackson DA; Kulanthaivel P; Mutlib AE; Espina RJ; Moody DE; Crouch DJ; Yost GS
    Chem Res Toxicol; 2003 Mar; 16(3):336-49. PubMed ID: 12641434
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biotransformation of sufentanil in liver microsomes of rats, dogs, and humans.
    Lavrijsen K; Van Houdt J; Van Dyck D; Hendrickx J; Lauwers W; Hurkmans R; Bockx M; Janssen C; Meuldermans W; Heykants J
    Drug Metab Dispos; 1990; 18(5):704-10. PubMed ID: 1981724
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 98.