1006 related articles for article (PubMed ID: 17411072)
1. Comparison of the RNase H cleavage kinetics and blood serum stability of the north-conformationally constrained and 2'-alkoxy modified oligonucleotides.
Honcharenko D; Barman J; Varghese OP; Chattopadhyaya J
Biochemistry; 2007 May; 46(19):5635-46. PubMed ID: 17411072
[TBL] [Abstract][Full Text] [Related]
2. Five- and six-membered conformationally locked 2',4'-carbocyclic ribo-thymidines: synthesis, structure, and biochemical studies.
Srivastava P; Barman J; Pathmasiri W; Plashkevych O; Wenska M; Chattopadhyaya J
J Am Chem Soc; 2007 Jul; 129(26):8362-79. PubMed ID: 17552524
[TBL] [Abstract][Full Text] [Related]
3. Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease activity, thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.
Upadhayaya R; Deshpande SG; Li Q; Kardile RA; Sayyed AY; Kshirsagar EK; Salunke RV; Dixit SS; Zhou C; Földesi A; Chattopadhyaya J
J Org Chem; 2011 Jun; 76(11):4408-31. PubMed ID: 21500818
[TBL] [Abstract][Full Text] [Related]
4. Antisense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved resistance to both exo and endonucleases.
Pradeepkumar PI; Amirkhanov NV; Chattopadhyaya J
Org Biomol Chem; 2003 Jan; 1(1):81-92. PubMed ID: 12929393
[TBL] [Abstract][Full Text] [Related]
5. Conformationally constrained 2'-N,4'-C-ethylene-bridged thymidine (aza-ENA-T): synthesis, structure, physical, and biochemical studies of aza-ENA-T-modified oligonucleotides.
Varghese OP; Barman J; Pathmasiri W; Plashkevych O; Honcharenko D; Chattopadhyaya J
J Am Chem Soc; 2006 Nov; 128(47):15173-87. PubMed ID: 17117869
[TBL] [Abstract][Full Text] [Related]
6. Synthesis of 2',4'-propylene-bridged (carba-ENA) thymidine and its analogues: the engineering of electrostatic and steric effects at the bottom of the minor groove for nuclease and thermodynamic stabilities and elicitation of RNase H.
Liu Y; Xu J; Karimiahmadabadi M; Zhou C; Chattopadhyaya J
J Org Chem; 2010 Nov; 75(21):7112-28. PubMed ID: 20929200
[TBL] [Abstract][Full Text] [Related]
7. Free-radical ring closure to conformationally locked α-L-carba-LNAs and synthesis of their oligos: nuclease stability, target RNA specificity, and elicitation of RNase H.
Li Q; Yuan F; Zhou C; Plashkevych O; Chattopadhyaya J
J Org Chem; 2010 Sep; 75(18):6122-40. PubMed ID: 20738147
[TBL] [Abstract][Full Text] [Related]
8. Double sugar and phosphate backbone-constrained nucleotides: synthesis, structure, stability, and their incorporation into oligodeoxynucleotides.
Zhou C; Plashkevych O; Chattopadhyaya J
J Org Chem; 2009 May; 74(9):3248-65. PubMed ID: 19348480
[TBL] [Abstract][Full Text] [Related]
9. Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2',4'-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties.
Zhou C; Liu Y; Andaloussi M; Badgujar N; Plashkevych O; Chattopadhyaya J
J Org Chem; 2009 Jan; 74(1):118-34. PubMed ID: 19055352
[TBL] [Abstract][Full Text] [Related]
10. Modulation of pyrene fluorescence in DNA probes depends upon the nature of the conformationally restricted nucleotide.
Honcharenko D; Zhou C; Chattopadhyaya J
J Org Chem; 2008 Apr; 73(7):2829-42. PubMed ID: 18331060
[TBL] [Abstract][Full Text] [Related]
11. Synthesis, physicochemical and biochemical studies of 1',2'-oxetane constrained adenosine and guanosine modified oligonucleotides, and their comparison with those of the corresponding cytidine and thymidine analogues.
Pradeepkumar PI; Cheruku P; Plashkevych O; Acharya P; Gohil S; Chattopadhyaya J
J Am Chem Soc; 2004 Sep; 126(37):11484-99. PubMed ID: 15366894
[TBL] [Abstract][Full Text] [Related]
12. Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids.
Lima WF; Crooke ST
Biochemistry; 1997 Jan; 36(2):390-8. PubMed ID: 9003192
[TBL] [Abstract][Full Text] [Related]
13. How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?
Plashkevych O; Li Q; Chattopadhyaya J
Mol Biosyst; 2017 May; 13(5):921-938. PubMed ID: 28352859
[TBL] [Abstract][Full Text] [Related]
14. The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis.
Lima WF; Rose JB; Nichols JG; Wu H; Migawa MT; Wyrzykiewicz TK; Vasquez G; Swayze EE; Crooke ST
Mol Pharmacol; 2007 Jan; 71(1):73-82. PubMed ID: 17028157
[TBL] [Abstract][Full Text] [Related]
15. Efficient RNase H-directed cleavage of RNA promoted by antisense DNA or 2'F-ANA constructs containing acyclic nucleotide inserts.
Mangos MM; Min KL; Viazovkina E; Galarneau A; Elzagheid MI; Parniak MA; Damha MJ
J Am Chem Soc; 2003 Jan; 125(3):654-61. PubMed ID: 12526664
[TBL] [Abstract][Full Text] [Related]
16. Synthesis of conformationally locked Carba-LNAs through intramolecular free-radical addition to C=N. Electrostatic and steric implication of the carba-LNA substituents in the modified oligos for nuclease and thermodynamic stabilities.
Xu J; Liu Y; Dupouy C; Chattopadhyaya J
J Org Chem; 2009 Sep; 74(17):6534-54. PubMed ID: 19670835
[TBL] [Abstract][Full Text] [Related]
17. Conformationally-2',4'-locked Aza-ENA and carbocyclic ribo-thymidine.
Chattopadhyaya J
Nucleic Acids Symp Ser (Oxf); 2007; (51):69-70. PubMed ID: 18029590
[TBL] [Abstract][Full Text] [Related]
18. RNase H1 can catalyze RNA/DNA hybrid formation and cleavage with stable hairpin or duplex DNA oligomers.
Li J; Wartell RM
Biochemistry; 1998 Apr; 37(15):5154-61. PubMed ID: 9548746
[TBL] [Abstract][Full Text] [Related]
19. Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.
Pattanayek R; Sethaphong L; Pan C; Prhavc M; Prakash TP; Manoharan M; Egli M
J Am Chem Soc; 2004 Nov; 126(46):15006-7. PubMed ID: 15547979
[TBL] [Abstract][Full Text] [Related]
20. A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H.
Zamaratski E; Pradeepkumar PI; Chattopadhyaya J
J Biochem Biophys Methods; 2001 May; 48(3):189-208. PubMed ID: 11384757
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
