BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

307 related articles for article (PubMed ID: 17420273)

  • 1. CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms.
    Ruas M; Gregory F; Jones R; Poolman R; Starborg M; Rowe J; Brookes S; Peters G
    Mol Cell Biol; 2007 Jun; 27(12):4273-82. PubMed ID: 17420273
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.
    Alcorta DA; Xiong Y; Phelps D; Hannon G; Beach D; Barrett JC
    Proc Natl Acad Sci U S A; 1996 Nov; 93(24):13742-7. PubMed ID: 8943005
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6.
    Jones R; Ruas M; Gregory F; Moulin S; Delia D; Manoukian S; Rowe J; Brookes S; Peters G
    Cancer Res; 2007 Oct; 67(19):9134-41. PubMed ID: 17909018
    [TBL] [Abstract][Full Text] [Related]  

  • 4. p16INK4A mediates cyclin dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells.
    Sandhu C; Peehl DM; Slingerland J
    Cancer Res; 2000 May; 60(10):2616-22. PubMed ID: 10825132
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Sequential extension of proliferative lifespan in human fibroblasts induced by over-expression of CDK4 or 6 and loss of p53 function.
    Morris M; Hepburn P; Wynford-Thomas D
    Oncogene; 2002 Jun; 21(27):4277-88. PubMed ID: 12082615
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence.
    Zou X; Ray D; Aziyu A; Christov K; Boiko AD; Gudkov AV; Kiyokawa H
    Genes Dev; 2002 Nov; 16(22):2923-34. PubMed ID: 12435633
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence.
    Brookes S; Gagrica S; Sanij E; Rowe J; Gregory FJ; Hara E; Peters G
    Cell Cycle; 2015; 14(8):1164-73. PubMed ID: 25695870
    [TBL] [Abstract][Full Text] [Related]  

  • 8. p21 loss cooperates with INK4 inactivation facilitating immortalization and Bcl-2-mediated anchorage-independent growth of oncogene-transduced primary mouse fibroblasts.
    Carbone CJ; Graña X; Reddy EP; Haines DS
    Cancer Res; 2007 May; 67(9):4130-7. PubMed ID: 17483323
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Expression of p16Ink4a compensates for p18Ink4c loss in cyclin-dependent kinase 4/6-dependent tumors and tissues.
    Ramsey MR; Krishnamurthy J; Pei XH; Torrice C; Lin W; Carrasco DR; Ligon KL; Xiong Y; Sharpless NE
    Cancer Res; 2007 May; 67(10):4732-41. PubMed ID: 17510401
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells.
    Sandhu C; Donovan J; Bhattacharya N; Stampfer M; Worland P; Slingerland J
    Oncogene; 2000 Nov; 19(47):5314-23. PubMed ID: 11103932
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
    Takeuchi S; Takahashi A; Motoi N; Yoshimoto S; Tajima T; Yamakoshi K; Hirao A; Yanagi S; Fukami K; Ishikawa Y; Sone S; Hara E; Ohtani N
    Cancer Res; 2010 Nov; 70(22):9381-90. PubMed ID: 21062974
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A.
    Fuxe J; Akusjärvi G; Goike HM; Roos G; Collins VP; Pettersson RF
    Cell Growth Differ; 2000 Jul; 11(7):373-84. PubMed ID: 10939591
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity.
    Calbó J; Serna C; Garriga J; Graña X; Mazo A
    Cell Death Differ; 2004 Oct; 11(10):1055-65. PubMed ID: 15309028
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells.
    Ramirez RD; Herbert BS; Vaughan MB; Zou Y; Gandia K; Morales CP; Wright WE; Shay JW
    Oncogene; 2003 Jan; 22(3):433-44. PubMed ID: 12545164
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Two mechanisms underlying the loss of p16(Ink4a) function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence.
    Wu X; Jia S; Zhang X; Si X; Tang W; Luo Y
    Mech Ageing Dev; 2012 Aug; 133(8):549-55. PubMed ID: 22813853
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation.
    Al-Khalaf HH; Hendrayani SF; Aboussekhra A
    Mol Cancer Res; 2011 Mar; 9(3):311-9. PubMed ID: 21270107
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression.
    Quereda V; Martinalbo J; Dubus P; Carnero A; Malumbres M
    Oncogene; 2007 Dec; 26(55):7665-74. PubMed ID: 17599058
    [TBL] [Abstract][Full Text] [Related]  

  • 18. p21Waf1/Cip1 plays a critical role in modulating senescence through changes of DNA methylation.
    Zheng QH; Ma LW; Zhu WG; Zhang ZY; Tong TJ
    J Cell Biochem; 2006 Aug; 98(5):1230-48. PubMed ID: 16514663
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A.
    McKenzie HA; Fung C; Becker TM; Irvine M; Mann GJ; Kefford RF; Rizos H
    Hum Mutat; 2010 Jun; 31(6):692-701. PubMed ID: 20340136
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Direct modulation of rheumatoid inflammatory mediator expression in retinoblastoma protein-dependent and -independent pathways by cyclin-dependent kinase 4/6.
    Nonomura Y; Nagasaka K; Hagiyama H; Sekine C; Nanki T; Tamamori-Adachi M; Miyasaka N; Kohsaka H
    Arthritis Rheum; 2006 Jul; 54(7):2074-83. PubMed ID: 16802342
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.