193 related articles for article (PubMed ID: 17428043)
1. Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.
Pace P; Di Francesco ME; Gardelli C; Harper S; Muraglia E; Nizi E; Orvieto F; Petrocchi A; Poma M; Rowley M; Scarpelli R; Laufer R; Gonzalez Paz O; Monteagudo E; Bonelli F; Hazuda D; Stillmock KA; Summa V
J Med Chem; 2007 May; 50(9):2225-39. PubMed ID: 17428043
[TBL] [Abstract][Full Text] [Related]
2. Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.
Gardelli C; Nizi E; Muraglia E; Crescenzi B; Ferrara M; Orvieto F; Pace P; Pescatore G; Poma M; Ferreira Mdel R; Scarpelli R; Homnick CF; Ikemoto N; Alfieri A; Verdirame M; Bonelli F; Paz OG; Taliani M; Monteagudo E; Pesci S; Laufer R; Felock P; Stillmock KA; Hazuda D; Rowley M; Summa V
J Med Chem; 2007 Oct; 50(20):4953-75. PubMed ID: 17824681
[TBL] [Abstract][Full Text] [Related]
3. 4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.
Summa V; Petrocchi A; Matassa VG; Gardelli C; Muraglia E; Rowley M; Paz OG; Laufer R; Monteagudo E; Pace P
J Med Chem; 2006 Nov; 49(23):6646-9. PubMed ID: 17154493
[TBL] [Abstract][Full Text] [Related]
4. Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection.
Summa V; Petrocchi A; Bonelli F; Crescenzi B; Donghi M; Ferrara M; Fiore F; Gardelli C; Gonzalez Paz O; Hazuda DJ; Jones P; Kinzel O; Laufer R; Monteagudo E; Muraglia E; Nizi E; Orvieto F; Pace P; Pescatore G; Scarpelli R; Stillmock K; Witmer MV; Rowley M
J Med Chem; 2008 Sep; 51(18):5843-55. PubMed ID: 18763751
[TBL] [Abstract][Full Text] [Related]
5. A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
Embrey MW; Wai JS; Funk TW; Homnick CF; Perlow DS; Young SD; Vacca JP; Hazuda DJ; Felock PJ; Stillmock KA; Witmer MV; Moyer G; Schleif WA; Gabryelski LJ; Jin L; Chen IW; Ellis JD; Wong BK; Lin JH; Leonard YM; Tsou NN; Zhuang L
Bioorg Med Chem Lett; 2005 Oct; 15(20):4550-4. PubMed ID: 16102965
[TBL] [Abstract][Full Text] [Related]
6. N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors.
Petrocchi A; Jones P; Rowley M; Fiore F; Summa V
Bioorg Med Chem Lett; 2009 Aug; 19(15):4245-9. PubMed ID: 19523819
[TBL] [Abstract][Full Text] [Related]
7. Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.
Wai JS; Kim B; Fisher TE; Zhuang L; Embrey MW; Williams PD; Staas DD; Culberson C; Lyle TA; Vacca JP; Hazuda DJ; Felock PJ; Schleif WA; Gabryelski LJ; Jin L; Chen IW; Ellis JD; Mallai R; Young SD
Bioorg Med Chem Lett; 2007 Oct; 17(20):5595-9. PubMed ID: 17822898
[TBL] [Abstract][Full Text] [Related]
8. Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.
Langford HM; Williams PD; Homnick CF; Vacca JP; Felock PJ; Stillmock KA; Witmer MV; Hazuda DJ; Gabryelski LJ; Schleif WA
Bioorg Med Chem Lett; 2008 Jan; 18(2):721-5. PubMed ID: 18078751
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV integrase inhibitors.
Boros EE; Edwards CE; Foster SA; Fuji M; Fujiwara T; Garvey EP; Golden PL; Hazen RJ; Jeffrey JL; Johns BA; Kawasuji T; Kiyama R; Koble CS; Kurose N; Miller WH; Mote AL; Murai H; Sato A; Thompson JB; Woodward MC; Yoshinaga T
J Med Chem; 2009 May; 52(9):2754-61. PubMed ID: 19374386
[TBL] [Abstract][Full Text] [Related]
10. 3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors.
Donghi M; Kinzel OD; Summa V
Bioorg Med Chem Lett; 2009 Apr; 19(7):1930-4. PubMed ID: 19269170
[TBL] [Abstract][Full Text] [Related]
11. Design and synthesis of novel N-hydroxy-dihydronaphthyridinones as potent and orally bioavailable HIV-1 integrase inhibitors.
Johnson TW; Tanis SP; Butler SL; Dalvie D; Delisle DM; Dress KR; Flahive EJ; Hu Q; Kuehler JE; Kuki A; Liu W; McClellan GA; Peng Q; Plewe MB; Richardson PF; Smith GL; Solowiej J; Tran KT; Wang H; Yu X; Zhang J; Zhu H
J Med Chem; 2011 May; 54(9):3393-417. PubMed ID: 21446745
[TBL] [Abstract][Full Text] [Related]
12. Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Melamed JY; Egbertson MS; Varga S; Vacca JP; Moyer G; Gabryelski L; Felock PJ; Stillmock KA; Witmer MV; Schleif W; Hazuda DJ; Leonard Y; Jin L; Ellis JD; Young SD
Bioorg Med Chem Lett; 2008 Oct; 18(19):5307-10. PubMed ID: 18774711
[TBL] [Abstract][Full Text] [Related]
13. Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.
Jin H; Metobo S; Jabri S; Mish M; Lansdown R; Chen X; Tsiang M; Wright M; Kim CU
Bioorg Med Chem Lett; 2009 Apr; 19(8):2263-5. PubMed ID: 19285389
[TBL] [Abstract][Full Text] [Related]
14. Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.
Verschueren WG; Dierynck I; Amssoms KI; Hu L; Boonants PM; Pille GM; Daeyaert FF; Hertogs K; Surleraux DL; Wigerinck PB
J Med Chem; 2005 Mar; 48(6):1930-40. PubMed ID: 15771437
[TBL] [Abstract][Full Text] [Related]
15. Azaindole hydroxamic acids are potent HIV-1 integrase inhibitors.
Plewe MB; Butler SL; Dress KR; Hu Q; Johnson TW; Kuehler JE; Kuki A; Lam H; Liu W; Nowlin D; Peng Q; Rahavendran SV; Tanis SP; Tran KT; Wang H; Yang A; Zhang J
J Med Chem; 2009 Nov; 52(22):7211-9. PubMed ID: 19873974
[TBL] [Abstract][Full Text] [Related]
16. Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
Zhuang L; Wai JS; Embrey MW; Fisher TE; Egbertson MS; Payne LS; Guare JP; Vacca JP; Hazuda DJ; Felock PJ; Wolfe AL; Stillmock KA; Witmer MV; Moyer G; Schleif WA; Gabryelski LJ; Leonard YM; Lynch JJ; Michelson SR; Young SD
J Med Chem; 2003 Feb; 46(4):453-6. PubMed ID: 12570367
[TBL] [Abstract][Full Text] [Related]
17. Quinolone carboxylic acids as a novel monoketo acid class of human immunodeficiency virus type 1 integrase inhibitors.
Sato M; Kawakami H; Motomura T; Aramaki H; Matsuda T; Yamashita M; Ito Y; Matsuzaki Y; Yamataka K; Ikeda S; Shinkai H
J Med Chem; 2009 Aug; 52(15):4869-82. PubMed ID: 19719237
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and biological evaluation of purine derivatives incorporating metal chelating ligands as HIV integrase inhibitors.
Li X; Vince R
Bioorg Med Chem; 2006 Aug; 14(16):5742-55. PubMed ID: 16753300
[TBL] [Abstract][Full Text] [Related]
19. Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.
Muraglia E; Kinzel O; Gardelli C; Crescenzi B; Donghi M; Ferrara M; Nizi E; Orvieto F; Pescatore G; Laufer R; Gonzalez-Paz O; Di Marco A; Fiore F; Monteagudo E; Fonsi M; Felock PJ; Rowley M; Summa V
J Med Chem; 2008 Feb; 51(4):861-74. PubMed ID: 18217703
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.
Naidu BN; Sorenson ME; Patel M; Ueda Y; Banville J; Beaulieu F; Bollini S; Dicker IB; Higley H; Lin Z; Pajor L; Parker DD; Terry BJ; Zheng M; Martel A; Meanwell NA; Krystal M; Walker MA
Bioorg Med Chem Lett; 2015 Feb; 25(3):717-20. PubMed ID: 25529736
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
