214 related articles for article (PubMed ID: 17429319)
1. Pregnane X receptor polymorphism affects CYP3A4 induction via a ligand-dependent interaction with steroid receptor coactivator-1.
Lim YP; Huang JD
Pharmacogenet Genomics; 2007 May; 17(5):369-82. PubMed ID: 17429319
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction.
Lim YP; Kuo SC; Lai ML; Huang JD
Pharmacogenet Genomics; 2009 Jan; 19(1):11-24. PubMed ID: 19077665
[TBL] [Abstract][Full Text] [Related]
3. Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region.
Koyano S; Kurose K; Saito Y; Ozawa S; Hasegawa R; Komamura K; Ueno K; Kamakura S; Kitakaze M; Nakajima T; Matsumoto K; Akasawa A; Saito H; Sawada J
Drug Metab Dispos; 2004 Jan; 32(1):149-54. PubMed ID: 14709632
[TBL] [Abstract][Full Text] [Related]
4. Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents.
Mani S; Huang H; Sundarababu S; Liu W; Kalpana G; Smith AB; Horwitz SB
Clin Cancer Res; 2005 Sep; 11(17):6359-69. PubMed ID: 16144941
[TBL] [Abstract][Full Text] [Related]
5. The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion.
Masuyama H; Suwaki N; Tateishi Y; Nakatsukasa H; Segawa T; Hiramatsu Y
Mol Endocrinol; 2005 May; 19(5):1170-80. PubMed ID: 15650019
[TBL] [Abstract][Full Text] [Related]
6. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression.
Li T; Chiang JY
Drug Metab Dispos; 2006 May; 34(5):756-64. PubMed ID: 16455805
[TBL] [Abstract][Full Text] [Related]
7. Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
Cerveny L; Svecova L; Anzenbacherova E; Vrzal R; Staud F; Dvorak Z; Ulrichova J; Anzenbacher P; Pavek P
Drug Metab Dispos; 2007 Jul; 35(7):1032-41. PubMed ID: 17392393
[TBL] [Abstract][Full Text] [Related]
8. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.
Svecova L; Vrzal R; Burysek L; Anzenbacherova E; Cerveny L; Grim J; Trejtnar F; Kunes J; Pour M; Staud F; Anzenbacher P; Dvorak Z; Pavek P
Drug Metab Dispos; 2008 Feb; 36(2):339-48. PubMed ID: 17998298
[TBL] [Abstract][Full Text] [Related]
9. Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element.
El-Sankary W; Bombail V; Gibson GG; Plant N
Drug Metab Dispos; 2002 Sep; 30(9):1029-34. PubMed ID: 12167569
[TBL] [Abstract][Full Text] [Related]
10. Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics.
Takeshita A; Taguchi M; Koibuchi N; Ozawa Y
J Biol Chem; 2002 Sep; 277(36):32453-8. PubMed ID: 12072427
[TBL] [Abstract][Full Text] [Related]
11. Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects.
Lim YP; Liu CH; Shyu LJ; Huang JD
Pharmacogenet Genomics; 2005 May; 15(5):337-41. PubMed ID: 15864135
[TBL] [Abstract][Full Text] [Related]
12. Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.
Takezawa T; Matsunaga T; Aikawa K; Nakamura K; Ohmori S
Drug Metab Pharmacokinet; 2012; 27(4):430-8. PubMed ID: 22333269
[TBL] [Abstract][Full Text] [Related]
13. The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha.
Liu FJ; Song X; Yang D; Deng R; Yan B
Biochem J; 2008 Jan; 409(1):243-50. PubMed ID: 17764444
[TBL] [Abstract][Full Text] [Related]
14. A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor.
Pondugula SR; Brimer-Cline C; Wu J; Schuetz EG; Tyagi RK; Chen T
Drug Metab Dispos; 2009 Apr; 37(4):719-30. PubMed ID: 19171678
[TBL] [Abstract][Full Text] [Related]
15. Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.
Bhalla S; Ozalp C; Fang S; Xiang L; Kemper JK
J Biol Chem; 2004 Oct; 279(43):45139-47. PubMed ID: 15322103
[TBL] [Abstract][Full Text] [Related]
16. Differential regulation of hepatic CYP2B6 and CYP3A4 genes by constitutive androstane receptor but not pregnane X receptor.
Faucette SR; Sueyoshi T; Smith CM; Negishi M; Lecluyse EL; Wang H
J Pharmacol Exp Ther; 2006 Jun; 317(3):1200-9. PubMed ID: 16513849
[TBL] [Abstract][Full Text] [Related]
17. Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans.
Handschin C; Podvinec M; Stöckli J; Hoffmann K; Meyer UA
Mol Endocrinol; 2001 Sep; 15(9):1571-85. PubMed ID: 11518807
[TBL] [Abstract][Full Text] [Related]
18. St John's wort, a herbal antidepressant, activates the steroid X receptor.
Wentworth JM; Agostini M; Love J; Schwabe JW; Chatterjee VK
J Endocrinol; 2000 Sep; 166(3):R11-6. PubMed ID: 10974665
[TBL] [Abstract][Full Text] [Related]
19. Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).
Johnson DR; Li CW; Chen LY; Ghosh JC; Chen JD
Mol Pharmacol; 2006 Jan; 69(1):99-108. PubMed ID: 16219912
[TBL] [Abstract][Full Text] [Related]
20. Natural protein variants of pregnane X receptor with altered transactivation activity toward CYP3A4.
Hustert E; Zibat A; Presecan-Siedel E; Eiselt R; Mueller R; Fuss C; Brehm I; Brinkmann U; Eichelbaum M; Wojnowski L; Burk O
Drug Metab Dispos; 2001 Nov; 29(11):1454-9. PubMed ID: 11602521
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]