245 related articles for article (PubMed ID: 17447748)
1. A high-throughput screen for aggregation-based inhibition in a large compound library.
Feng BY; Simeonov A; Jadhav A; Babaoglu K; Inglese J; Shoichet BK; Austin CP
J Med Chem; 2007 May; 50(10):2385-90. PubMed ID: 17447748
[TBL] [Abstract][Full Text] [Related]
2. An Aggregation Advisor for Ligand Discovery.
Irwin JJ; Duan D; Torosyan H; Doak AK; Ziebart KT; Sterling T; Tumanian G; Shoichet BK
J Med Chem; 2015 Sep; 58(17):7076-87. PubMed ID: 26295373
[TBL] [Abstract][Full Text] [Related]
3. Screening in a spirit haunted world.
Shoichet BK
Drug Discov Today; 2006 Jul; 11(13-14):607-15. PubMed ID: 16793529
[TBL] [Abstract][Full Text] [Related]
4. Identification and prediction of promiscuous aggregating inhibitors among known drugs.
Seidler J; McGovern SL; Doman TN; Shoichet BK
J Med Chem; 2003 Oct; 46(21):4477-86. PubMed ID: 14521410
[TBL] [Abstract][Full Text] [Related]
5. Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures.
Feng BY; Shoichet BK
J Med Chem; 2006 Apr; 49(7):2151-4. PubMed ID: 16570910
[TBL] [Abstract][Full Text] [Related]
6. Interpreting steep dose-response curves in early inhibitor discovery.
Shoichet BK
J Med Chem; 2006 Dec; 49(25):7274-7. PubMed ID: 17149857
[TBL] [Abstract][Full Text] [Related]
7. A detergent-based assay for the detection of promiscuous inhibitors.
Feng BY; Shoichet BK
Nat Protoc; 2006; 1(2):550-3. PubMed ID: 17191086
[TBL] [Abstract][Full Text] [Related]
8. High-throughput assays for promiscuous inhibitors.
Feng BY; Shelat A; Doman TN; Guy RK; Shoichet BK
Nat Chem Biol; 2005 Aug; 1(3):146-8. PubMed ID: 16408018
[TBL] [Abstract][Full Text] [Related]
9. Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists.
LaPlante SR; Carson R; Gillard J; Aubry N; Coulombe R; Bordeleau S; Bonneau P; Little M; O'Meara J; Beaulieu PL
J Med Chem; 2013 Jun; 56(12):5142-50. PubMed ID: 23730910
[TBL] [Abstract][Full Text] [Related]
10. Colloid formation by drugs in simulated intestinal fluid.
Doak AK; Wille H; Prusiner SB; Shoichet BK
J Med Chem; 2010 May; 53(10):4259-65. PubMed ID: 20426472
[TBL] [Abstract][Full Text] [Related]
11. Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors.
Coan KE; Shoichet BK
J Am Chem Soc; 2008 Jul; 130(29):9606-12. PubMed ID: 18588298
[TBL] [Abstract][Full Text] [Related]
12. Biodiversity of small molecules--a new perspective in screening set selection.
Petrone PM; Wassermann AM; Lounkine E; Kutchukian P; Simms B; Jenkins J; Selzer P; Glick M
Drug Discov Today; 2013 Jul; 18(13-14):674-80. PubMed ID: 23454345
[TBL] [Abstract][Full Text] [Related]
13. Non-stoichiometric inhibition in integrated lead finding - a literature review.
Klumpp M
Expert Opin Drug Discov; 2016; 11(2):149-62. PubMed ID: 26653534
[TBL] [Abstract][Full Text] [Related]
14. Structural Analysis and Identification of Colloidal Aggregators in Drug Discovery.
Yang ZY; Yang ZJ; Dong J; Wang LL; Zhang LX; Ding JJ; Ding XQ; Lu AP; Hou TJ; Cao DS
J Chem Inf Model; 2019 Sep; 59(9):3714-3726. PubMed ID: 31430151
[TBL] [Abstract][Full Text] [Related]
15. Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.
Jadhav A; Ferreira RS; Klumpp C; Mott BT; Austin CP; Inglese J; Thomas CJ; Maloney DJ; Shoichet BK; Simeonov A
J Med Chem; 2010 Jan; 53(1):37-51. PubMed ID: 19908840
[TBL] [Abstract][Full Text] [Related]
16. Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
Babaoglu K; Simeonov A; Irwin JJ; Nelson ME; Feng B; Thomas CJ; Cancian L; Costi MP; Maltby DA; Jadhav A; Inglese J; Austin CP; Shoichet BK
J Med Chem; 2008 Apr; 51(8):2502-11. PubMed ID: 18333608
[TBL] [Abstract][Full Text] [Related]
17. Stability and equilibria of promiscuous aggregates in high protein milieus.
Coan KE; Shoichet BK
Mol Biosyst; 2007 Mar; 3(3):208-13. PubMed ID: 17308667
[TBL] [Abstract][Full Text] [Related]
18. Mass spectrometric techniques for label-free high-throughput screening in drug discovery.
Roddy TP; Horvath CR; Stout SJ; Kenney KL; Ho PI; Zhang JH; Vickers C; Kaushik V; Hubbard B; Wang YK
Anal Chem; 2007 Nov; 79(21):8207-13. PubMed ID: 17902631
[TBL] [Abstract][Full Text] [Related]
19. Effect of detergent on "promiscuous" inhibitors.
Ryan AJ; Gray NM; Lowe PN; Chung CW
J Med Chem; 2003 Jul; 46(16):3448-51. PubMed ID: 12877581
[TBL] [Abstract][Full Text] [Related]
20. Identification of small molecule aggregators from large compound libraries by support vector machines.
Rao H; Li Z; Li X; Ma X; Ung C; Li H; Liu X; Chen Y
J Comput Chem; 2010 Mar; 31(4):752-63. PubMed ID: 19569201
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
