These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

194 related articles for article (PubMed ID: 17452323)

  • 1. Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A.
    López-Viñas E; Bentebibel A; Gurunathan C; Morillas M; de Arriaga D; Serra D; Asins G; Hegardt FG; Gómez-Puertas P
    J Biol Chem; 2007 Jun; 282(25):18212-18224. PubMed ID: 17452323
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition.
    Morillas M; Gómez-Puertas P; Bentebibel A; Sellés E; Casals N; Valencia A; Hegardt FG; Asins G; Serra D
    J Biol Chem; 2003 Mar; 278(11):9058-63. PubMed ID: 12499375
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme.
    Napal L; Dai J; Treber M; Haro D; Marrero PF; Woldegiorgis G
    J Biol Chem; 2003 Sep; 278(36):34084-9. PubMed ID: 12826662
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis.
    Liu H; Zheng G; Treber M; Dai J; Woldegiorgis G
    J Biol Chem; 2005 Feb; 280(6):4524-31. PubMed ID: 15579906
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effects of DL-2-bromopalmitoyl-CoA and bromoacetyl-CoA in rat liver and heart mitochondria. Inhibition of carnitine palmitoyltransferase and displacement of [14C]malonyl-CoA from mitochondrial binding sites.
    Edwards MR; Bird MI; Saggerson ED
    Biochem J; 1985 Aug; 230(1):169-79. PubMed ID: 4052034
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification by mutagenesis of conserved arginine and glutamate residues in the C-terminal domain of rat liver carnitine palmitoyltransferase I that are important for catalytic activity and malonyl-CoA sensitivity.
    Treber M; Dai J; Woldegiorgis G
    J Biol Chem; 2003 Mar; 278(13):11145-9. PubMed ID: 12540837
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain.
    Morillas M; Gómez-Puertas P; Rubí B; Clotet J; Ariño J; Valencia A; Hegardt FG; Serra D; Asins G
    J Biol Chem; 2002 Mar; 277(13):11473-80. PubMed ID: 11790793
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Use of six chimeric proteins to investigate the role of intramolecular interactions in determining the kinetics of carnitine palmitoyltransferase I isoforms.
    Jackson VN; Cameron JM; Fraser F; Zammit VA; Price NT
    J Biol Chem; 2000 Jun; 275(26):19560-6. PubMed ID: 10766754
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The extreme C terminus of rat liver carnitine palmitoyltransferase I is not involved in malonyl-CoA sensitivity but in initial protein folding.
    Pan Y; Cohen I; Guillerault F; Fève B; Girard J; Prip-Buus C
    J Biol Chem; 2002 Dec; 277(49):47184-9. PubMed ID: 12351641
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity.
    Morillas M; Gómez-Puertas P; Roca R; Serra D; Asins G; Valencia A; Hegardt FG
    J Biol Chem; 2001 Nov; 276(48):45001-8. PubMed ID: 11553629
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The first 28 N-terminal amino acid residues of human heart muscle carnitine palmitoyltransferase I are essential for malonyl CoA sensitivity and high-affinity binding.
    Shi J; Zhu H; Arvidson DN; Woldegiorgis G
    Biochemistry; 2000 Feb; 39(4):712-7. PubMed ID: 10651636
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pig liver carnitine palmitoyltransferase. Chimera studies show that both the N- and C-terminal regions of the enzyme are important for the unusual high malonyl-CoA sensitivity.
    Nicot C; Relat J; Woldegiorgis G; Haro D; Marrero PF
    J Biol Chem; 2002 Mar; 277(12):10044-9. PubMed ID: 11790778
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pig muscle carnitine palmitoyltransferase I (CPTI beta), with low Km for carnitine and low sensitivity to malonyl-CoA inhibition, has kinetic characteristics similar to those of the rat liver (CPTI alpha) enzyme.
    Relat J; Nicot C; Gacias M; Woldegiorgis G; Marrero PF; Haro D
    Biochemistry; 2004 Oct; 43(39):12686-91. PubMed ID: 15449958
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Binding of malonyl-CoA to isolated mitochondria. Evidence for high- and low-affinity sites in liver and heart and relationship to inhibition of carnitine palmitoyltransferase activity.
    Bird MI; Saggerson ED
    Biochem J; 1984 Sep; 222(3):639-47. PubMed ID: 6487267
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Substitution of glutamate-3, valine-19, leucine-23, and serine-24 with alanine in the N-terminal region of human heart muscle carnitine palmitoyltransferase I abolishes malonyl CoA inhibition and binding.
    Zhu H; Shi J; Treber M; Dai J; Arvidson DN; Woldegiorgis G
    Arch Biochem Biophys; 2003 May; 413(1):67-74. PubMed ID: 12706342
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Deletion of the conserved first 18 N-terminal amino acid residues in rat liver carnitine palmitoyltransferase I abolishes malonyl-CoA sensitivity and binding.
    Shi J; Zhu H; Arvidson DN; Cregg JM; Woldegiorgis G
    Biochemistry; 1998 Aug; 37(31):11033-8. PubMed ID: 9692998
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of positive and negative determinants of malonyl-CoA sensitivity and carnitine affinity within the amino termini of rat liver- and muscle-type carnitine palmitoyltransferase I.
    Jackson VN; Zammit VA; Price NT
    J Biol Chem; 2000 Dec; 275(49):38410-6. PubMed ID: 10969089
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Hepatic carnitine palmitoyltransferase-I has two independent inhibitory binding sites for regulation of fatty acid oxidation.
    Kashfi K; Mynatt RL; Cook GA
    Biochim Biophys Acta; 1994 May; 1212(2):245-52. PubMed ID: 8180250
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity.
    Faye A; Borthwick K; Esnous C; Price NT; Gobin S; Jackson VN; Zammit VA; Girard J; Prip-Buus C
    Biochem J; 2005 Apr; 387(Pt 1):67-76. PubMed ID: 15498023
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Malonyl-CoA binding site and the overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane.
    Murthy MS; Pande SV
    Proc Natl Acad Sci U S A; 1987 Jan; 84(2):378-82. PubMed ID: 3540964
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.