475 related articles for article (PubMed ID: 17464088)
1. Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.
Lee MH; Cho YS; Han YM
Stem Cells; 2007 Jul; 25(7):1654-63. PubMed ID: 17464088
[TBL] [Abstract][Full Text] [Related]
2. Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA.
Porter KE; Turner NA; O'Regan DJ; Balmforth AJ; Ball SG
Cardiovasc Res; 2004 Mar; 61(4):745-55. PubMed ID: 14985071
[TBL] [Abstract][Full Text] [Related]
3. HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway.
Fuchs D; Berges C; Opelz G; Daniel V; Naujokat C
Biochem Biophys Res Commun; 2008 Sep; 374(2):309-14. PubMed ID: 18625202
[TBL] [Abstract][Full Text] [Related]
4. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin.
Takeda N; Kondo M; Ito S; Ito Y; Shimokata K; Kume H
Am J Respir Cell Mol Biol; 2006 Dec; 35(6):722-9. PubMed ID: 16858009
[TBL] [Abstract][Full Text] [Related]
5. Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGF-beta2 in human retinal pigment epithelial cells.
Itoh Y; Kimoto K; Imaizumi M; Nakatsuka K
Exp Eye Res; 2007 Mar; 84(3):464-72. PubMed ID: 17217948
[TBL] [Abstract][Full Text] [Related]
6. Simvastatin antagonizes tumor necrosis factor-alpha inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway.
Yamashita M; Otsuka F; Mukai T; Otani H; Inagaki K; Miyoshi T; Goto J; Yamamura M; Makino H
J Endocrinol; 2008 Mar; 196(3):601-13. PubMed ID: 18310456
[TBL] [Abstract][Full Text] [Related]
7. HMG-CoA reductase regulates CCL17-induced colon cancer cell migration via geranylgeranylation and RhoA activation.
Al-Haidari AA; Syk I; Thorlacius H
Biochem Biophys Res Commun; 2014 Mar; 446(1):68-72. PubMed ID: 24582560
[TBL] [Abstract][Full Text] [Related]
8. Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA.
Tang D; Park HJ; Georgescu SP; Sebti SM; Hamilton AD; Galper JB
Life Sci; 2006 Sep; 79(15):1484-92. PubMed ID: 16740276
[TBL] [Abstract][Full Text] [Related]
9. Statins suppress THP-1 cell migration and secretion of matrix metalloproteinase 9 by inhibiting geranylgeranylation.
Wong B; Lumma WC; Smith AM; Sisko JT; Wright SD; Cai TQ
J Leukoc Biol; 2001 Jun; 69(6):959-62. PubMed ID: 11404382
[TBL] [Abstract][Full Text] [Related]
10. Statins inhibit blastocyst formation by preventing geranylgeranylation.
Alarcon VB; Marikawa Y
Mol Hum Reprod; 2016 May; 22(5):350-63. PubMed ID: 26908642
[TBL] [Abstract][Full Text] [Related]
11. Simvastatin reduces lipoprotein-associated phospholipase A2 in lipopolysaccharide-stimulated human monocyte-derived macrophages through inhibition of the mevalonate-geranylgeranyl pyrophosphate-RhoA-p38 mitogen-activated protein kinase pathway.
Song JX; Ren JY; Chen H
J Cardiovasc Pharmacol; 2011 Feb; 57(2):213-22. PubMed ID: 21052011
[TBL] [Abstract][Full Text] [Related]
12. Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivation.
Fernández-Hernando C; Suárez Y; Lasunción MA
Mol Cell Neurosci; 2005 Aug; 29(4):591-602. PubMed ID: 15951198
[TBL] [Abstract][Full Text] [Related]
13. Decreased C-reactive protein-induced resistin production in human monocytes by simvastatin.
Hu WL; Qiao SB; Li JJ
Cytokine; 2007 Dec; 40(3):201-6. PubMed ID: 18023360
[TBL] [Abstract][Full Text] [Related]
14. Simvastatin inhibits C-reactive protein-induced pro-inflammatory changes in endothelial cells by decreasing mevalonate pathway products.
Liang YJ; Shyu KG; Wang BW; Lai LP
Cardiology; 2008; 110(3):182-90. PubMed ID: 18057884
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of the RhoA/Rho-associated, coiled-coil-containing protein kinase-1 pathway is involved in the therapeutic effects of simvastatin on pulmonary arterial hypertension.
Liu WH; Xu XH; Luo Q; Zhang HL; Wang Y; Xi QY; Zhao ZH; Liu ZH
Clin Exp Hypertens; 2018; 40(3):224-230. PubMed ID: 29319354
[TBL] [Abstract][Full Text] [Related]
16. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors decrease Fas ligand expression and cytotoxicity in activated human T lymphocytes.
Blanco-Colio LM; Muñoz-García B; Martín-Ventura JL; Lorz C; Díaz C; Hernández G; Egido J
Circulation; 2003 Sep; 108(12):1506-13. PubMed ID: 12952848
[TBL] [Abstract][Full Text] [Related]
17. Apoptosis of rheumatoid synovial cells by statins through the blocking of protein geranylgeranylation: a potential therapeutic approach to rheumatoid arthritis.
Nagashima T; Okazaki H; Yudoh K; Matsuno H; Minota S
Arthritis Rheum; 2006 Feb; 54(2):579-86. PubMed ID: 16447234
[TBL] [Abstract][Full Text] [Related]
18. Long-term inhibition of RhoA attenuates vascular contractility by enhancing endothelial NO production in an intact rabbit mesenteric artery.
Shiga N; Hirano K; Hirano M; Nishimura J; Nawata H; Kanaide H
Circ Res; 2005 May; 96(9):1014-21. PubMed ID: 15817883
[TBL] [Abstract][Full Text] [Related]
19. Simvastatin induces osteogenic differentiation of murine embryonic stem cells.
Pagkalos J; Cha JM; Kang Y; Heliotis M; Tsiridis E; Mantalaris A
J Bone Miner Res; 2010 Nov; 25(11):2470-8. PubMed ID: 20564244
[TBL] [Abstract][Full Text] [Related]
20. Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels.
Turner NA; O'Regan DJ; Ball SG; Porter KE
FASEB J; 2005 May; 19(7):804-6. PubMed ID: 15728660
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
