BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

147 related articles for article (PubMed ID: 17464412)

  • 1. Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin.
    Andrews SP; Tait MM; Ball M; Ley SV
    Org Biomol Chem; 2007 May; 5(9):1427-36. PubMed ID: 17464412
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Total synthesis of five thapsigargins: guaianolide natural products exhibiting sub-nanomolar SERCA inhibition.
    Andrews SP; Ball M; Wierschem F; Cleator E; Oliver S; Högenauer K; Simic O; Antonello A; Hünger U; Smith MD; Ley SV
    Chemistry; 2007; 13(20):5688-712. PubMed ID: 17508363
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Total synthesis of two novel subpicomolar sarco/endoplasmatic reticulum Ca2+-ATPase inhibitors designed by an analysis of the binding site of thapsigargin.
    Søhoel H; Liljefors T; Ley SV; Oliver SF; Antonello A; Smith MD; Olsen CE; Isaacs JT; Christensen SB
    J Med Chem; 2005 Nov; 48(22):7005-11. PubMed ID: 16250659
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Applying linear interaction energy method for rational design of noncompetitive allosteric inhibitors of the sarco- and endoplasmic reticulum calcium-ATPase.
    Singh P; Mhaka AM; Christensen SB; Gray JJ; Denmeade SR; Isaacs JT
    J Med Chem; 2005 Apr; 48(8):3005-14. PubMed ID: 15828839
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and SERCA activities of structurally simplified cyclopiazonic acid analogues.
    Yao S; Gallenkamp D; Wölfel K; Lüke B; Schindler M; Scherkenbeck J
    Bioorg Med Chem; 2011 Aug; 19(15):4669-78. PubMed ID: 21719297
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Total synthesis of thapsigargin, a potent SERCA pump inhibitor.
    Ball M; Andrews SP; Wierschem F; Cleator E; Smith MD; Ley SV
    Org Lett; 2007 Feb; 9(4):663-6. PubMed ID: 17256950
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs.
    Winther AM; Liu H; Sonntag Y; Olesen C; le Maire M; Soehoel H; Olsen CE; Christensen SB; Nissen P; Møller JV
    J Biol Chem; 2010 Sep; 285(37):28883-92. PubMed ID: 20551329
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Regulation of sarco/endoplasmic and plasma membrane calcium ATPase gene expression by calcium in cultured human lens epithelial cells.
    Marian MJ; Mukhopadhyay P; Borchman D; Tang D; Paterson CA
    Cell Calcium; 2007 Jan; 41(1):87-95. PubMed ID: 16875731
    [TBL] [Abstract][Full Text] [Related]  

  • 9. SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis.
    Appendino G; Prosperini S; Valdivia C; Ballero M; Colombano G; Billington RA; Genazzani AA; Sterner O
    J Nat Prod; 2005 Aug; 68(8):1213-7. PubMed ID: 16124763
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Inhibition of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase by flavonoids: a quantitative structure-activity relationship study.
    Ogunbayo OA; Harris RM; Waring RH; Kirk CJ; Michelangeli F
    IUBMB Life; 2008 Dec; 60(12):853-8. PubMed ID: 18785622
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Differential effects of thapsigargin analogues on apoptosis of prostate cancer cells: complex regulation by intracellular calcium.
    Dubois C; Vanden Abeele F; Sehgal P; Olesen C; Junker S; Christensen SB; Prevarskaya N; Møller JV
    FEBS J; 2013 Nov; 280(21):5430-40. PubMed ID: 23927406
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular determinants of sarco/endoplasmic reticulum calcium ATPase inhibition by hydroquinone-based compounds.
    Lape M; Elam C; Versluis M; Kempton R; Paula S
    Proteins; 2008 Feb; 70(3):639-49. PubMed ID: 17879345
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Divergent synthesis of thapsigargin analogs.
    Chu H; Dünstl G; Felding J; Baran PS
    Bioorg Med Chem Lett; 2018 Sep; 28(16):2705-2707. PubMed ID: 29636219
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibitor of sarco-endoplasmic reticulum Ca2+-ATPase thapsigargin stimulates production of nitric oxide and secretion of interferon-gamma.
    Kmonícková E; Melkusová P; Harmatha J; Vokác K; Farghali H; Zídek Z
    Eur J Pharmacol; 2008 Jun; 588(1):85-92. PubMed ID: 18457829
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A diversity of SERCA Ca2+ pump inhibitors.
    Michelangeli F; East JM
    Biochem Soc Trans; 2011 Jun; 39(3):789-97. PubMed ID: 21599650
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular determinants of thapsigargin binding by SERCA Ca2+-ATPase: a computational docking study.
    Paula S; Ball WJ
    Proteins; 2004 Aug; 56(3):595-606. PubMed ID: 15229891
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identifying the sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) as a potential target for hypericin--a theoretical study.
    Eriksson ES; Eriksson LA
    Phys Chem Chem Phys; 2012 Sep; 14(36):12637-46. PubMed ID: 22892582
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase.
    Skytte DM; Møller JV; Liu H; Nielsen HØ; Svenningsen LE; Jensen CM; Olsen CE; Christensen SB
    Bioorg Med Chem; 2010 Aug; 18(15):5634-46. PubMed ID: 20615710
    [TBL] [Abstract][Full Text] [Related]  

  • 19. From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development.
    Christensen SB; Simonsen HT; Engedal N; Nissen P; Møller JV; Denmeade SR; Isaacs JT
    Prog Chem Org Nat Prod; 2021; 115():59-114. PubMed ID: 33797641
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeting thapsigargin towards tumors.
    Doan NT; Paulsen ES; Sehgal P; Møller JV; Nissen P; Denmeade SR; Isaacs JT; Dionne CA; Christensen SB
    Steroids; 2015 May; 97():2-7. PubMed ID: 25065587
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.