BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

231 related articles for article (PubMed ID: 17490884)

  • 1. beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action.
    Xiang J; Ipek M; Suri V; Tam M; Xing Y; Huang N; Zhang Y; Tobin J; Mansour TS; McKew J
    Bioorg Med Chem; 2007 Jul; 15(13):4396-405. PubMed ID: 17490884
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
    Xiang J; Ipek M; Suri V; Massefski W; Pan N; Ge Y; Tam M; Xing Y; Tobin JF; Xu X; Tam S
    Bioorg Med Chem Lett; 2005 Jun; 15(11):2865-9. PubMed ID: 15911270
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of novel inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 by docking and pharmacophore modeling.
    Yang H; Dou W; Lou J; Leng Y; Shen J
    Bioorg Med Chem Lett; 2008 Feb; 18(4):1340-5. PubMed ID: 18242087
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors.
    Yan X; Wang Z; Sudom A; Cardozo M; DeGraffenreid M; Di Y; Fan P; He X; Jaen JC; Labelle M; Liu J; Ma J; McMinn D; Miao S; Sun D; Tang L; Tu H; Ursu S; Walker N; Ye Q; Powers JP
    Bioorg Med Chem Lett; 2010 Dec; 20(23):7071-5. PubMed ID: 20971000
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.
    Stanetty C; Czollner L; Koller I; Shah P; Gaware R; Cunha TD; Odermatt A; Jordis U; Kosma P; Classen-Houben D
    Bioorg Med Chem; 2010 Nov; 18(21):7522-41. PubMed ID: 20851614
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors.
    Yuan C; St Jean DJ; Liu Q; Cai L; Li A; Han N; Moniz G; Askew B; Hungate RW; Johansson L; Tedenborg L; Pyring D; Williams M; Hale C; Chen M; Cupples R; Zhang J; Jordan S; Bartberger MD; Sun Y; Emery M; Wang M; Fotsch C
    Bioorg Med Chem Lett; 2007 Nov; 17(22):6056-61. PubMed ID: 17919905
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.
    Gaware R; Khunt R; Czollner L; Stanetty C; Da Cunha T; Kratschmar DV; Odermatt A; Kosma P; Jordis U; Classen-Houben D
    Bioorg Med Chem; 2011 Mar; 19(6):1866-80. PubMed ID: 21376605
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.
    Hult M; Shafqat N; Elleby B; Mitschke D; Svensson S; Forsgren M; Barf T; Vallgårda J; Abrahmsen L; Oppermann U
    Mol Cell Endocrinol; 2006 Mar; 248(1-2):26-33. PubMed ID: 16431016
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase type 1.
    Xu Z; Tice CM; Zhao W; Cacatian S; Ye YJ; Singh SB; Lindblom P; McKeever BM; Krosky PM; Kruk BA; Berbaum J; Harrison RK; Johnson JA; Bukhtiyarov Y; Panemangalore R; Scott BB; Zhao Y; Bruno JG; Togias J; Guo J; Guo R; Carroll PJ; McGeehan GM; Zhuang L; He W; Claremon DA
    J Med Chem; 2011 Sep; 54(17):6050-62. PubMed ID: 21786805
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
    Sutin L; Andersson S; Bergquist L; Castro VM; Danielsson E; James S; Henriksson M; Johansson L; Kaiser C; Flyrén K; Williams M
    Bioorg Med Chem Lett; 2007 Sep; 17(17):4837-40. PubMed ID: 17600707
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
    Roche D; Carniato D; Leriche C; Lepifre F; Christmann-Franck S; Graedler U; Charon C; Bozec S; Doare L; Schmidlin F; Lecomte M; Valeur E
    Bioorg Med Chem Lett; 2009 May; 19(10):2674-8. PubMed ID: 19395260
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Adamantyl triazoles as selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
    Olson S; Aster SD; Brown K; Carbin L; Graham DW; Hermanowski-Vosatka A; LeGrand CB; Mundt SS; Robbins MA; Schaeffer JM; Slossberg LH; Szymonifka MJ; Thieringer R; Wright SD; Balkovec JM
    Bioorg Med Chem Lett; 2005 Oct; 15(19):4359-62. PubMed ID: 16039856
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.
    Yeh VS; Patel JR; Yong H; Kurukulasuriya R; Fung S; Monzon K; Chiou W; Wang J; Stolarik D; Imade H; Beno D; Brune M; Jacobson P; Sham H; Link JT
    Bioorg Med Chem Lett; 2006 Oct; 16(20):5414-9. PubMed ID: 16899366
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
    Wan ZK; Chenail E; Xiang J; Li HQ; Ipek M; Bard J; Svenson K; Mansour TS; Xu X; Tian X; Suri V; Hahm S; Xing Y; Johnson CE; Li X; Qadri A; Panza D; Perreault M; Tobin JF; Saiah E
    J Med Chem; 2009 Sep; 52(17):5449-61. PubMed ID: 19673466
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Piperidine amides as 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
    Flyrén K; Bergquist LO; Castro VM; Fotsch C; Johansson L; St Jean DJ; Sutin L; Williams M
    Bioorg Med Chem Lett; 2007 Jun; 17(12):3421-5. PubMed ID: 17442567
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.
    Patel JR; Shuai Q; Dinges J; Winn M; Pliushchev M; Fung S; Monzon K; Chiou W; Wang J; Pan L; Wagaw S; Engstrom K; Kerdesky FA; Longenecker K; Judge R; Qin W; Imade HM; Stolarik D; Beno DW; Brune M; Chovan LE; Sham HL; Jacobson P; Link JT
    Bioorg Med Chem Lett; 2007 Feb; 17(3):750-5. PubMed ID: 17110106
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 11beta-hydroxysteroid dehydrogenase type 1 inhibitors for metabolic syndrome.
    Schnackenberg CG
    Curr Opin Investig Drugs; 2008 Mar; 9(3):295-300. PubMed ID: 18311666
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery and biological evaluation of adamantyl amide 11beta-HSD1 inhibitors.
    Webster SP; Ward P; Binnie M; Craigie E; McConnell KM; Sooy K; Vinter A; Seckl JR; Walker BR
    Bioorg Med Chem Lett; 2007 May; 17(10):2838-43. PubMed ID: 17350260
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.
    Yeh VS; Kurukulasuriya R; Madar D; Patel JR; Fung S; Monzon K; Chiou W; Wang J; Jacobson P; Sham HL; Link JT
    Bioorg Med Chem Lett; 2006 Oct; 16(20):5408-13. PubMed ID: 16890427
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor.
    Hale C; Véniant M; Wang Z; Chen M; McCormick J; Cupples R; Hickman D; Min X; Sudom A; Xu H; Matsumoto G; Fotsch C; St Jean DJ; Wang M
    Chem Biol Drug Des; 2008 Jan; 71(1):36-44. PubMed ID: 18069989
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.